Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2011 -2013
Author : OTA Haruko
The dementia, e.g. Alzheimer' disease, in the elderly people is increasing in our country every year. As a pathogenic mechanism of Alzheimer' disease, polymerization of beta amyloid (Ab) and Hyper-phosphorylation of Tau protein are known. The increase in Ab production, the increase in GM1ganglioside which changes structure of Ab, control of Ab degradation system are pointed out as mechanisms of Ab accumulation. Anesthesia for such a patient is also increasing. This study demonstrated that propofol and a barbital decrease Ab polymerization in neurons by controlling revelation of GM1, and to control cell death. Moreover, ketamine and droperidol decreased the activity of neprilysin which decomposes Ab, and it became clear to promote accumulation of Ab.