Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism NATURE PUBLISHING GROUP 31 (9) 1930 - 41 0271-678X 2011/09 [Refereed]
Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: pleiotrophin-PTPRZ-A signaling is involved in oligodendrocyte differentiation [Not invited]
Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION [Not invited]
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2017/04 -2020/03
Author : Kuboyama Kazuya
The purpose of this study was to determine the functional significance of the chondroitin sulfate-modification of PTPRZ, which inhibits oligodendrocyte differentiation and myelination/remyelination. Here we revealed that protamin, also known as a heparin antagonist, effectively neutralized the inhibitory activities chondroitin sulfate proteoglycans including PTPRZ, thereby enhancing oligodendrocyte differentiation and (re)myelination. Moreover, we demonstrated that the tyrosine phosphorylation of AFAP1L2, an adaptor protein involved in the PI3K-AKT pathway, was enhanced in OPC-like OL1 cells by a inhibitory ligand of PTPRZ, pleiotrophin.
記憶形成とその破綻機構の解析
Tokushima Bunri University:Educational Reform and Collaborative Research
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2014/04 -2016/03
Author : KUBOYAMA Kazuya
The purpose of this study was to determine the regulatory mechanism of protein tyrosine phosphatase receptor type Z (PTPRZ), which inhibits oligodendrocyte differentiation and myelination/remyelination. Here we revealed that the expression of pleiotrophin is transiently upregulated in damaged neurons after demyelination. Pleiotrophin may be released from demyelinated axons and bind to PTPRZ at the cell surface of oligodendrocyte precursor cells, thereby releases the block of differentiation into oligodendrocyte, so the remyelination of neighboring axon is initiated.
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2012/04 -2014/03
Author : KUBOYAMA Kazuya
The purpose of this study was to determine the tyrosine phosphorylation signaling to regulate the oligodendrocyte differentiation and myelination in the central nervous system (CNS). The non-receptor protein tyrosine kinase Fyn, which is a member of the Src family of kinases, is known to induce oligodendrocyte development, and myelination. Here we revealed that Ptprz, which is a member of the receptor-like protein tyrosine phosphatase (RPTP) family, functions as the counterpart PTP for Fyn in the oligodendrocyte differentiation and myelination. In the study, Ptprz was found to regulate proper oligodendrocyte differentiation in early CNS development, and suppress remyelination at the injury site induced by the experimental autoimmune encephalomyelitis (EAE), through the dephosphorylation of p190RhoGAP that is phosphorylated by Fyn.
Teaching Experience
学術論文入門ユニット(医学部 2年)学術論文入門ユニット(医学部 2年) Nagoya City University
治療薬学2(香川薬学部 2年前期)治療薬学2(香川薬学部 2年前期) Tokushima Bunri University
薬理学実習(香川薬学部 3年前期)薬理学実習(香川薬学部 3年前期) Tokushima Bunri University