Researcher Database



FacultyGraduate School of Pharmaceutical Sciences Department of Biological Chemistry
PositionAssociate Professor
Last Updated :2020/01/09

Researcher Profile and Settings


  •  - 1997 , The University of Tokyo

Research Activities

Published Papers

  • TDP-43 accelerates deadenylation of target mRNAs by recruiting Caf1 deadenylase., Fukushima M, Hosoda N, Chifu K, Hoshino SI, FEBS letters, 593, (3) 277 - 287, 12 , Refereed
  • A novel method for stabilizing microRNA mimics., Nogimori T, Furutachi K, Ogami K, Hosoda N, Hoshino SI, Biochemical and biophysical research communications, 511, (2) 422 - 426, 04 , Refereed
  • Dom34 mediates targeting of exogenous RNA in the antiviral OAS/RNase L pathway., Nogimori T, Nishiura K, Kawashima S, Nagai T, Oishi Y, Hosoda N, Imataka H, Kitamura Y, Kitade Y, Hoshino SI, Nucleic acids research, 47, (1) 432 - 449, 11 , Refereed
  • Proteolysis: a double-edged sword for the development of amyloidoses., Okamoto A, Hosoda N, Hoshino SI, Prion, 1 - 7, 09 , Refereed
  • Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail., Sawazaki R, Imai S, Yokogawa M, Hosoda N, Hoshino SI, Mio M, Mio K, Shimada I, Osawa M, Scientific reports, 8, (1) , 01 , Refereed
  • Proteolysis suppresses spontaneous prion generation in yeast., Okamoto A, Hosoda N, Tanaka A, Newnam GP, Chernoff YO, Hoshino SI, The Journal of biological chemistry, 292, (49) 20113 - 20124, 12 , Refereed
  • Arsenite inhibits mRNA deadenylation through proteolytic degradation of Tob and Pan3., Yamagishi R, Hosoda N, Hoshino S, Biochemical and biophysical research communications, 455, (3-4) 323 - 331, 12 , Refereed
  • The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor., Hashimoto Y, Kumagai N, Hosoda N, Hoshino S, Biochemical and biophysical research communications, 445, (3) 639 - 644, 03 , Refereed
  • Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB, K. Ogami, N. Hosoda, Y. Funakoshi, S. Hoshino, Oncogene, 33, 55 - 64, 01 02 , The regulation of mRNA deadenylation constitutes a pivotal mechanism of the post-transcriptional control of gene expression. Here we show that the antiproliferative protein Tob, a component of the Caf1-Ccr4 deadenylase complex, is involved in regulating the expression of the proto-oncogene c-myc. The c-myc mRNA contains cis elements (CPEs) in its 3′-untranslated region (3′-UTR), which are recognized by the cytoplasmic polyadenylation element-binding protein (CPEB). CPEB recruits Caf1 deadenylase through interaction with Tob to form a ternary complex, CPEB-Tob-Caf1, and negatively regulates the expression of c-myc by accelerating the deadenylation and decay of its mRNA. In quiescent cells, c-myc mRNA is destabilized by the trans-acting complex (CPEB-Tob-Caf1), while in cells stimulated by the serum, both Tob and Caf1 are released from CPEB, and c-Myc expression is induced early after stimulation by the stabilization of its mRNA as an 'immediate-early gene'. Collectively, these results indicate that Tob is a key factor in the regulation of c-myc gene expression, which is essential for cell growth. Thus, Tob appears to function in the control of cell growth at least, in part, by regulating the expression of c-myc. © 2014 Macmillan Publishers Limited.
  • The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells., Saito S, Hosoda N, Hoshino S, The Journal of biological chemistry, 288, (24) 17832 - 17843, 06 , Refereed
  • Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis., Hashimoto Y, Hosoda N, Datta P, Alnemri ES, Hoshino S, Apoptosis : an international journal on programmed cell death, 17, (12) 1287 - 1299, 12 , Refereed
  • Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay., Osawa M, Hosoda N, Nakanishi T, Uchida N, Kimura T, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I, RNA (New York, N.Y.), 18, (11) 1957 - 1967, 11 , Refereed
  • Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase., Hosoda N, Funakoshi Y, Hirasawa M, Yamagishi R, Asano Y, Miyagawa R, Ogami K, Tsujimoto M, Hoshino S, The EMBO journal, 30, (7) 1311 - 1323, 04 , Refereed
  • Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation., Ruan L, Osawa M, Hosoda N, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I, The Journal of biological chemistry, 285, (36) 27624 - 27631, 09 , Refereed
  • Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay, Isken O, Kim YK, Hosoda N, Mayeur GL, Hershey JW, Maquat LE, Cell, 133, 314-327, (2) 314 - 327, 04 , Refereed
  • Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay, Sato H, Hosoda N, Maquat LE, Molecular cell, 29, 255-262, (2) 255 - 262, 02 , Refereed
  • Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases, Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S, Genes & development, 21, 3135-3148, (23) 3135 - 3148, 12 , Refereed
  • Failsafe nonsense-mediated decay does not detectably target eIF4E-bound mRNA., Matsuda D, Hosoda N, Kim YK, Maquat LE, Nature structural & molecular biology, 14, 974-979, (10) 974 - 979, 10 , Refereed
  • [Features of NMD (nonsense-mediated mRNA decay) in mammalian cells]., Hosoda N, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 51, (16 Suppl) 2544 - 2548, 12 , Refereed
  • Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails., Hosoda N, Lejeune F, Maquat LE, Molecular and cellular biology, 26, (8) 3085 - 3097, 04 , Refereed
  • CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells., Hosoda N, Kim YK, Lejeune F, Maquat LE, Nature structural & molecular biology, 12/,893-901, (10) 893 - 901, 10 , Refereed
  • Translation termination factor eRF3 mediates mRNA decay through the regulation of deadenylation., Hosoda N, Kobayashi T, Uchida N, Funakoshi Y, Kikuchi Y, Hoshino S, Katada T, The Journal of biological chemistry, 278/,38287-38291, (40) 38287 - 38291, 10 , Refereed
  • Enzymaic and signal transduction properties of CD38/NADase and PC-1/ phosphodiesterase., Chem. Immunol., 75/,60-78
  • Novel function of the Eukaryotic Polypeptide-chain Releasing Factor 3 (eRF3/GSPT) in the Mechanism of mRNA Degradation., Biochemistry, 64/,1367-1372
  • Inhibition of phosphodiesterase/pyrophosphatase activity of PC-1 by its association with glycosaminoglycans., 265/,763-770
  • Protein-tyrosine phosphorylation by IgG1 subclass CD38 monoclonal antibodies is mediated through stimulation of the FcgII receptors in human myeloid cell lines., J. Immunol., 159/,5226-5232


  • 躍進するRNA研究 進展する構造解析,機能性RNAの多彩な役割の解明とRNAiなど生命・医工学への応用 第2章 RNAによる遺伝子発現調節 3)翻訳調節とmRNA動態 2.ウイルスRNA翻訳制御, 細田直, 野本明男, 実験医学, 22, (17) 2469 - 2474,   2004 11 25


  • 特願2016-219227, 特開2018-074954
  • 特願2014-263857, 特開2015-226531
  • 特願2014-107562, 特開2015-221026

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