Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Date (from‐to) : 2019/04 -2021/03
Author : Yohei Yamaguchi
The mechanical stress, derived from high hydrostatic pressure such as intraocular and blood pressure, modifies a contraction and relaxation of the ciliary muscle and cardiac muscle. However, the effect of physiological hydrostatic pressure on these myocytes is still unclear due to the lack of a quantitative measurement system that works under hydrostatic pressure at the cellular level. Here, we have first challenged to develop a quantitative measurement system to observe the cellular dynamics under hydrostatic pressure. And then, we have succeeded in developing a novel system to monitor cellular and intracellular calcium dynamics with electrical stimulation and drug intervention under high hydrostatic pressure. Furthermore, we successfully found the pressure-induced phenomenon on mouse cardiomyocytes and bovine ciliary muscle cells using the developed system.
急性伸展ストレスによる動的心筋バイオメカニクス制御の分子機構解明
旭川医科大学基金支援事業:研究活動助成
Date (from‐to) : 2020 -2021
Author : 山口陽平
眼内圧由来メカニカルストレスによる毛様体筋のCa2+動態制御メカニズムの研究
秋山記念生命科学振興財団:研究助成(奨励)
Date (from‐to) : 2019/09 -2020/03
Author : 山口 陽平
瞳孔括約筋から紐解く加齢に伴う瞳孔径変化メカニズムの研究
旭川医科大学:抗加齢医学プロジェクト
Date (from‐to) : 2018 -2019
Author : 山口 陽平
心筋細胞における機械受容メカニズムの電気生理学的研究
日本学術振興会:若手研究者海外挑戦プログラム
Date (from‐to) : 2017 -2018
Author : 山口 陽平
国際交流(研究集会)援助
公益財団法人ライフサイエンス振興財団:
Date (from‐to) : 2016
Author : 山口 陽平
Teaching Experience
Basic Principles of Pathological MedicineBasic Principles of Pathological Medicine Nagoya City University