Researcher Database


KONO Takao

FacultyGraduate School of Pharmaceutical Sciences Department of Biomedical Science
Last Updated :2020/07/03

Researcher Profile and Settings

Profile & Settings

    Research funding number:70581742
    ORCID ID:0000-0003-2557-4281


  •  - 2010 , Nagoya City University, Graduate School of Pharmaceutical Sciences
  •  - 2007 , Nagoya City University, Graduate School of Pharmaceutical Sciences
  •  - 2005 , Meijo University


  • 名古屋市立大学大学院薬学研究科博士後期課程 修了/博士(薬学)

Association Memberships

  • Society for Neuroscience

Research Activities

Research Areas

  • Life sciences, Pharmaceuticals - health and biochemistry
  • Life sciences, Neuroscience - general
  • Life sciences, Neuroscience - general

Research Interests


Published Papers

  • Assay for Reelin-Cleaving Activity of ADAMTS and Detection of Reelin and Its Fragments in the Brain., Ogino H, Yamakage Y, Yamashita MB, Kohno T, Hattori M, Methods in molecular biology, 2043, 105 - 111, Refereed
  • Expression and Preparation of Recombinant Reelin and ADAMTS-3 Proteins., Kohno T, Ogino H, Yamakage Y, Hattori M, Methods in molecular biology, 2043, 93 - 104, Refereed
  • Semaphorin 6A–Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons, Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata, iScience, 21, 359 - 374, 11 22 , Refereed, © 2019 The Authors Precise regulation of neuronal migration termination is crucial for the establishment of brain cytoarchitectures. However, little is known about how neurons terminate migration. Here we focused on interactions between migrating cortical neurons and their substrates, radial glial (RG) cells, and analyzed the role of Plexin A2 and A4 (PlxnA2/A4) receptors and their repulsive ligand, Semaphorin 6A (Sema6A), for this process. In both PlxnA2/A4 double-knockout and Sema6A mutant mice, the outermost cortical plate neurons ectopically invade layer 1 at a stage when they should reach their destinations. PlxnA2/A4 proteins are abundantly expressed on their leading processes, whereas Sema6A mRNA is enriched in RG cell somata. Cell-targeted gene expression and conditional knockouts indicate critical roles for these molecules. We hypothesize that the timely appearance of repulsive signaling mediated by Sema6A–PlxnA2/A4 weakens migrating neuron–RG cell interactions, leading to migration termination.
  • A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum., Yamakage Y, Kato M, Hongo A, Ogino H, Ishii K, Ishizuka T, Kamei T, Tsuiji H, Miyamoto T, Oishi H, Kohno T, Hattori M, Molecular and cellular neurosciences, 100, 09 , Refereed
  • Differential binding of anti-Reelin monoclonal antibodies reveals the characteristics of Reelin protein under various conditions., Ishii K, Kohno T, Hattori M, Biochemical and biophysical research communications, 05 , Refereed
  • Mechanisms of noradrenergic modulation of synaptic transmission and neuronal excitability in ventral horn neurons of the rat spinal cord., Shoji H, Ohashi M, Hirano T, Watanabe K, Endo N, Baba H, Kohno T, Neuroscience, 408, 161 - 176, 04 , Refereed
  • Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse., Yamakage Y, Tsuiji H, Kohno T, Ogino H, Saito T, Saido TC, Hattori M, Biological & pharmaceutical bulletin, 42, (3) 354 - 356, Refereed
  • [Functions of Reelin in cortical neuron migration]., Kohno T, Hattori M, Seikagaku. The Journal of Japanese Biochemical Society, 88, (1) 105 - 113, 02 , Refereed
  • [Molecular mechanism and physiological significance of proteolytic cleavage of Reelin]., Kohno T, Hattori M, Seikagaku. The Journal of Japanese Biochemical Society, 82, (10) 963 - 971, 10 , Refereed


  • 巨大分泌タンパク質リーリンによる神経細胞移動の制御機構, 河野孝夫, 服部光治, 生化学, 88, (1) 105 - 113,   2016
  • リーリン, 河野 孝夫, 服部 光治, 脳科学辞典,   2013
  • 「細胞外シグナル分子リーリンの分解機構と生理的意義」, 河野孝夫, 服部光治, 生化学, 82, (10) 963 - 971,   2010


  • ADAMTS-3を用いたリーリン分解, 2012-180354
  • 抗体とその利用, 2011-179161

Awards & Honors

  •   2016 , The Pharmaceutical Society of Japan Tokai Branch Academic Award

Research Grants & Projects

  • 巨大分泌蛋白質リーリンのシグナル活性機構と、その精神神経疾患における重要性の解明,   2017  - 2019
  • 脳の形成と機能を司る分泌蛋白質リーリンの、機能制御機構の解明とその創薬への応用,   2014  - 2016
  • 精神神経疾患の診断・治療を目指した、巨大分泌蛋白質リーリンの特異的分解機構の解明,   2012  - 2014
  • 脳形成に必須な分泌蛋白質リーリンの、特異的分解による機能制御機構の解明,   2010  - 2012

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