Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2013/04 -2016/03
Author : Aoki Yasuhiro; FUKUTA MAMIKO
Japanese population data of 323 female and 424 male samples on 27 loci of X-chromosomal short tandem repeats (X-STRs) were collected and analysed. A simulation study using the population data elucidated that X-STRs are useful to confirm the father-daughter relationships and female sibships sharing the father, namely full sibships and paternal half shibships. For the calculation of the likelihood ratio of female sibship, a linkage model on the basis of identity by descent approach were presented. In this model, 1) the linkage disequilibrium was taken into account regarding a cluster as a haplotype. and 2) the mutation was considered only when there was an apparent contradiction. This computation method is less complicated and could obtain reasonable likelihood ratios, therefore, should be effective to evaluate the kinship with X chromosomal polymorphic markers.