Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2018/04 -2022/03
Author : Sakuma Eisuke
We aimed to test the hypothesis that ASIC2a mRNA expression might correlate to the morphological development of the cerebellum. To that end, we examined the development of cerebellar cortex in the rats from embryonal day 15 to 14 day-old after birth compared with 28-day and 2-years old rats’ cerebellums focusing on the ASIC2a mRNA expression by using in situ detection of ASIC2a mRNA transcription using the RNA scope detection kit. We observed that ASIC2a expression migrates in a manner consistent with the migration of granule cells from the outer to the inner layers of the cerebellar cortex during cerebellogenesis. This suggests that ASIC2a is involved in enhancing synaptic neurotransmission when cell migration occurs during postnatal cerebellar circuit construction, and that ASIC1a is always maintained as the basis of synaptic neurotransmission.