Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2016/04 -2020/03
Author : Hishida Asahi
We conducted the genome-wide association study (GWAS) of gastric atrophy (GA) (diagnosed based on pepsinogen 1 [PG1] <= 70ng/ml & PG1/PG2 <= 3), severe gastric atrophy (sGA) (PG1 <= 30ng/ml & PG1/PG2 <= 2) and PG1/PG2 ratio using the data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study (n = 3,385) and Hospital-based Epidemiologic Research Program at Aichi Cancer Center 2 (HERPACC2)(n = 2,885), and found that PSCA SNPs on 8q24.3, which also reportedly associate with the risk of Helicobacter pylori-induced gastric cancer, reached the GWAS significant levels, and subsequent SNP-set analysis supported these findings by the statistically significant associations of PSCA gene with each of the three traits of GA, sGA and PG1/PG2 ratio.