Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2010 -2012
Author : TOZAWA Keiichi; KOHRI Kenjiro; OKADA Atsushi; HIROSE Masahito; HAYASHI Yutaro
The present lifestyle causes lifestyle-related diseases, such as diabetes, hyperlipidemia, hypertension, and arteriosclerosis, through fat accumulation and overweight. In this research, it showed clearly that the gene expression of adipocytokines relates to the morbidity of a urinary stone disease, and proved that the application to medical treatment is possible. Furthermore, the cytokine promotes adhesion molecules and NF-kappa B-RANK- RANKL signal, and so progress of arteriosclerosis. Same signal transduction inquired by considering that urolithiasis formation is also carrying out the same mechanism. The correlation to urinary stone formation of a RANK- RANKL signal transfer system was not able to be proved.NF-kappa B was activated by many extracellular stimuli, such as oxidant stress. Then, activation of inflammatory cytokine and a macrophage was promoted and it was checked that NF-kappa B plays an important role for urolithiasis formation.