The Japanese Society of Gastroenterology 日本消化管学会 JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY 日本消化器癌発生学会 JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 日本臨床腫瘍学会 日本カプセル内視鏡学会 日本光線力学学会 THE JAPANESE CANCER ASSOCIATION JAPAN SOCIETY OF CLINICAL ONCOLOGY THE JAPANESE SOCIETY OF INTERNAL MEDICINE 国際消化器発癌学会(ISGC)
The Japanese Society of Gastroenterology 日本消化管学会 JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY 日本消化器癌発生学会 JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 日本臨床腫瘍学会 日本カプセル内視鏡学会 日本光線力学学会 THE J...See More
The Japanese Society of Gastroenterology 日本消化管学会 JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY 日本消化器癌発生学会 JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 日本臨床腫瘍学会 日本カプセル内視鏡学会 日本光線力学学会 THE JAPANESE CANCER ASSOCIATION JAPAN SOCIETY OF CLINICAL ONCOLOGY THE JAPANESE SOCIETY OF INTERNAL MEDICINE 国際消化器発癌学会(ISGC)
World journal of gastrointestinal oncology 16 (7) 3357 - 3363 2024/07
BRAF K601E-mutated metastatic colorectal cancer in response to combination therapy with encorafenib, binimetinib, and cetuximab: A case report.Makiko Sasaki; Takaya Shimura; Hirotada Nishie; Keita Kur...See More
Unanticipated pathological clearance in two cases of clinical T4b dMMR/MSI-h advanced colorectal cancer: the potential of immune checkpoint inhibitors despite positive positron-emission tomography res...See More
A case of asymptomatic gastric plexiform fibromyxoma followed up for 3 years.Naomi Sugimura; Eiji Kubota; Makiko Sasaki; Shigeki Fukusada; Yusuke Mizuno; Hiroyasu Iwasaki; Mamoru Tanaka; Keiji Ozeki; ...See More
Digestion S. Karger AG 105 (3) 192 - 200 0012-2823 2024/02
Clinical Impact of Proton Pump Inhibitor and Potassium-Competitive Acid Blocker for Predicting the Curability of Endoscopic Resection in Ulcerative Early Gastric CancerKonomu Uno; Takaya Shimura; Shin...See More
Journal of Gastroenterology Springer Science and Business Media LLC 59 (2) 81 - 94 0944-1174 2023/11
Induction of ferroptosis by photodynamic therapy and enhancement of antitumor effect with ferroptosis inducersYuki Kojima; Mamoru Tanaka; Makiko Sasaki; Keiji Ozeki; Takaya Shimura; Eiji Kubota; Hirom...See More
Cellular Oncology Springer Science and Business Media LLC 47 (1) 229 - 244 2211-3428 2023/08
Osteopontin secreted from obese adipocytes enhances angiogenesis and promotes progression of pancreatic ductal adenocarcinoma in obesityShigeki Fukusada; Takaya Shimura; Makoto Natsume; Ruriko Nishiga...See More
Reovirus combined with a STING agonist enhances anti-tumor immunity in a mouse model of colorectal cancer.Naomi Sugimura; Eiji Kubota; Yoshinori Mori; Mineyoshi Aoyama; Mamoru Tanaka; Takaya Shimura; ...See More
Journal of clinical medicine research 15 (3) 181 - 186 2023/03
Induction Therapy With a Combination of Weekly Adalimumab Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis in Patients With Ulcerative Colitis and Failure of Conventional Agents, Biologics...See More
タラポルフィンPDTはフェロトーシスを誘導しフェロトーシス誘導物質と相乗効果を起こす(Photodynamic therapy with Talaporfin sodium(TS-PDT) induces Ferroptosis and synergizes with Ferroptosis inducer)
小島 悠揮; 田中 守; 佐々木 槙子; 志村 貴也; 久保田 英嗣; 片岡 洋望
日本癌学会総会記事 (一社)日本癌学会 81回 P - 2068 0546-0476 2022/09
タラポルフィンPDTはフェロトーシスを誘導しフェロトーシス誘導物質と相乗効果を起こす(Photodynamic therapy with Talaporfin sodium(TS-PDT) induces Ferroptosis and synergizes with Ferroptosis inducer)小島 悠揮; 田中 守; 佐々木 槙子; 志村 貴也; 久保田 英嗣; 片岡 洋望日本癌学...See More
タラポルフィンPDTはフェロトーシスを誘導しフェロトーシス誘導物質と相乗効果を起こす(Photodynamic therapy with Talaporfin sodium(TS-PDT) induces Ferroptosis and synergizes with Ferroptosis inducer)
小島 悠揮; 田中 守; 佐々木 槙子; 志村 貴也; 久保田 英嗣; 片岡 洋望
日本癌学会総会記事 (一社)日本癌学会 81回 P - 2068 0546-0476 2022/09
がん免疫療法としての光線力学的療法の可能性と将来の展望(Potentiality and future prospects of photodynamic therapy as cancer immunity therapy)
佐々木 槙子; 田中 守; 小島 悠揮; 西江 裕忠; 志村 貴也; 久保田 英嗣; 片岡 洋望
日本癌学会総会記事 (一社)日本癌学会 81回 E - 3012 0546-0476 2022/09
がん免疫療法としての光線力学的療法の可能性と将来の展望(Potentiality and future prospects of photodynamic therapy as cancer immunity therapy)佐々木 槙子; 田中 守; 小島 悠揮; 西江 裕忠; 志村 貴也; 久保田 英嗣; 片岡 洋望日本癌学会総会記事 (一社)日本癌学会 81回 E - 3012 0546-0...See More
がん免疫療法としての光線力学的療法の可能性と将来の展望(Potentiality and future prospects of photodynamic therapy as cancer immunity therapy)
佐々木 槙子; 田中 守; 小島 悠揮; 西江 裕忠; 志村 貴也; 久保田 英嗣; 片岡 洋望
日本癌学会総会記事 (一社)日本癌学会 81回 E - 3012 0546-0476 2022/09
T Kanno; T Katano; T Shimura; R Nishigaki; Y Kojima; M Sasaki; Y Okuda; N Sugimura; S Fukusada; Y Mizuno; H Iwasaki; H Nishie; M Tanaka; K Ozeki; E Kubota; S Tanida; H Kataoka
Characteristic endoscopic findings of gastrointestinal malignant lymphomas other than mucosa-associated lymphoid tissue lymphoma.T Kanno; T Katano; T Shimura; R Nishigaki; Y Kojima; M Sasaki; Y Okuda;...See More
T Kanno; T Katano; T Shimura; R Nishigaki; Y Kojima; M Sasaki; Y Okuda; N Sugimura; S Fukusada; Y Mizuno; H Iwasaki; H Nishie; M Tanaka; K Ozeki; E Kubota; S Tanida; H Kataoka
Malignant gastrointestinal neuroectodermal tumor presenting with small intestinal obstruction: A case report.Makiko Sasaki; Mamoru Tanaka; Koki Asukai; Hiroki Koguchi; Yusuke Inoue; Mizuki Moriyama; T...See More
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 54 (7) 905 - 910 2021/12
Relationship between gene mutations and clinicopathological features in nonampullary duodenal epithelial tumors.Shigeki Fukusada; Takaya Shimura; Hiroyasu Iwasaki; Yusuke Okuda; Takahito Katano; Takan...See More
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 54 (7) 905 - 910 2021/12
Journal of clinical medicine research 13 (10-11) 510 - 514 2021/11
Combination Therapy With Ustekinumab Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis in Patients With Refractory Ulcerative Colitis.Satoshi Tanida; Keiji Ozeki; Takuya Kanno; Takahito Kat...See More
5-aminolaevulinic acid (5-ALA) accumulates in GIST-T1 cells and photodynamic diagnosis using 5-ALA identifies gastrointestinal stromal tumors (GISTs) in xenograft tumor models.Makiko Sasaki; Mamoru Ta...See More
Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma.Yusuke Okuda; Takaya Shimura; Hiroyasu Iwasaki; Takahito Katano; Mika Kitagawa; Ruriko Nishigaki...See More
Journal of clinical medicine research 12 (1) 36 - 40 2020/01 [Refereed]
Combination Therapy With Tofacitinib Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis as Induction Therapy for Refractory Ulcerative Colitis.Satoshi Tanida; Keiji Ozeki; Tsutomu Mizoshita;...See More
Anticancer research 39 (8) 4199 - 4206 0250-7005 2019/08 [Refereed]
Antitumor Effect of a Novel Photodynamic Therapy With Acetylated Glucose-conjugated Chlorin for Gastrointestinal Cancers.Hiroshi Ichikawa; Hirotada Nishie; Shigenobu Yano; Yuki Komai; Hiroaki Yamaguch...See More
A Basic Study of Photodynamic Therapy with Glucose-Conjugated Chlorin e6 Using Mammary Carcinoma XenograftsTomohiro Osaki; Shota Hibino; Inoru Yokoe; Hiroaki Yamaguchi; Akihiro Nomoto; Shigenobu Yano;...See More
Clinical Journal of Gastroenterology Springer Science and Business Media {LLC} 12 (2) 193 - 195 1865-7257 2019/04 [Refereed]
Proton-pump inhibitor-induced fundic gland polyps with hematemesisMamoru Tanaka; Hiromi Kataoka; Takashi YagiClinical Journal of Gastroenterology Springer Science and Business Media {LLC} 12 (2) 193 -...See More
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 22 (3) 295 - 300 1744-9979 2018/06 [Refereed]
Combination Therapy With Intensive Granulocyte and Monocyte Adsorptive Apheresis Plus Ustekinumab in Patients With Refractory Crohn's Disease.Satoshi Tanida; Tsutomu Mizoshita; Keiji Ozeki; Takahito K...See More
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 22 (3) 295 - 300 1744-9979 2018/06 [Refereed]
Biochemical and biophysical research communications 496 (4) 1204 - 1209 0006-291X 2018/02 [Refereed]
Excellent antitumor effects for gastrointestinal cancers using photodynamic therapy with a novel glucose conjugated chlorin e6.Hirotada Nishie; Hiromi Kataoka; Shigenobu Yano; Hiroaki Yamaguchi; Akihi...See More
Anish Thomas; Mamoru Tanaka; Jane Trepel; William C. Reinhold; Vinodh N. Rajapakse; Yves Pommier
CANCER RESEARCH AMER ASSOC CANCER RESEARCH 77 (4) 823 - 826 0008-5472 2017/02 [Refereed]
Temozolomide in the Era of Precision MedicineAnish Thomas; Mamoru Tanaka; Jane Trepel; William C. Reinhold; Vinodh N. Rajapakse; Yves PommierCANCER RESEARCH AMER ASSOC CANCER RESEARCH 77 (4) 823 - 826...See More
Maltotriose conjugation to a chlorin derivative enhances the antitumor effects of photodynamic therapy in peritoneal dissemination of pancreatic cancerKato, A.; Kataoka, H.; Yano, S.; Hayashi, K.; Hay...See More
ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 36 (11) 6005 - 6009 0250-7005 2016/11 [Refereed]
Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric CancerNoriyuki Hayashi; Hiromi Kataoka; Shigenobu Yano; Jun-Ichi Kikuchi; Mamoru Tanaka; Hi...See More
Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin)Mamoru Tanaka; Hiromi Kataoka; Shigenobu Yano; Takuya Sawada; Haruo Akashi; Masahiro Inoue; Shugo...See More
Nippon Laser Igakkaishi Japan Society for Laser Surgery and Medicine 36 (2) 159 - 165 2015
Tumor Affinity Photosensitizers for Photodynamic TherapyKataoka Hiromi; Hayashi Noriyuki; Tanaka Mamoru; Kubota Eiji; Yano Shigenobu; Joh TakashiNippon Laser Igakkaishi Japan Society for Laser Surgery...See More
Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cellsShingo Hamano; Yoshinori Mori; Mineyoshi Aoyama; Hiromi Kata...See More
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY LIPPINCOTT WILLIAMS & WILKINS 26 (5) 504 - 509 0954-691X 2014/05 [Refereed]
Management of systolic blood pressure after endoscopic submucosal dissection is crucial for prevention of post-ESD gastric bleedingMasahide Ebi; Takaya Shimura; Hirotaka Nishiwaki; Mamoru Tanaka; Hiro...See More
MOLECULAR CANCER THERAPEUTICS AMER ASSOC CANCER RESEARCH 13 (4) 767 - 775 1535-7163 2014/04 [Refereed]
Antitumor Effects in Gastrointestinal Stromal Tumors Using Photodynamic Therapy with a Novel Glucose-Conjugated ChlorinMamoru Tanaka; Hiromi Kataoka; Shigenobu Yano; Hiromi Ohi; Kazuhiro Moriwaki; Har...See More
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE HINDAWI PUBLISHING CORPORATION 2014 828137 1741-427X 2014 [Refereed]
Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled StudyTakeshi Kamiy...See More
American Journal of Gastroenterology 108 (12) 1935 - 1936 0002-9270 2013/12 [Refereed]
Neurofibroma of the esophagus complicating von recklinghausen's neurofibromatosisMamoru Tanaka; Hiromi Kataoka; Takashi JohAmerican Journal of Gastroenterology 108 (12) 1935 - 1936 0002-9270 2013/12 [...See More
Kataoka H; Mizuno K; Hayashi N; Tanaka M; Nishiwaki H; Ebi M; Mizoshita T; Mori Y; Kubota E; Tanida S; Kamiya T; Joh T
World journal of gastrointestinal endoscopy 5 (9) 440 - 445 2013/09 [Refereed]
Diagnostic utility of small-caliber and conventional endoscopes for gastric cancer and analysis of endoscopic false-negative gastric cancers.Kataoka H; Mizuno K; Hayashi N; Tanaka M; Nishiwaki H; Ebi ...See More
BMC CANCER BIOMED CENTRAL LTD 13 237 1471-2407 2013/05 [Refereed]
Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cellsMamoru Tanaka; Hiromi Kataoka; Shigenobu Yano; Hi...See More
The role of neuregulin4 and HER4 in gastrointestinal malignant lymphomaMasahide Ebi; Hiromi Kataoka; Takaya Shimura; Yoshikazu Hirata; Takashi Mizushima; Tsutomu Mizoshita; Mamoru Tanaka; Hironobu Tsu...See More
CARDIOVASCULAR TOLERANCE AND AUTONOMIC NERVOUS RESPONSES IN UNSEDATED UPPER GASTROINTESTINAL SMALL-CALIBER ENDOSCOPY: A COMPARISON BETWEEN TRANSNASAL AND PERORAL PROCEDURES WITH NEWLY DEVELOPED MOUTHP...See More
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 402 (3) 449 - 454 0006-291X 2010/11 [Refereed]
TGF beta induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cellsMasahide Ebi; Hiromi Kataoka; Takaya Shimura; Eiji Kubota; Yoshikazu Hirata; Takashi Mizushi...See More
AMERICAN JOURNAL OF PATHOLOGY AMER SOC INVESTIGATIVE PATHOLOGY, INC 177 (2) 955 - 963 0002-9440 2010/08 [Refereed]
Role of ES Cell-Expressed Ras (ERas) in Tumorigenicity of Gastric CancerEiji Kubota; Hiromi Kataoka; Mineyoshi Aoyama; Tsutomu Mizoshita; Yoshinori Mori; Takaya Shimura; Mamoru Tanaka; Makoto Sasaki; ...See More
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 398 (2) 321 - 325 0006-291X 2010/07 [Refereed]
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transductionMotoshi Mabuchi; Hiromi Kata...See More
H. Kataoka; N. Hayashi; M. Tanaka; E. Kubota; S. Yano; T. Joh JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 30- 4 -4 2015/12
Cancer cell selective photodynamic therapy using glucose-conjugated and oligosaccharide-conjugated chlorinsH. Kataoka; N. Hayashi; M. Tanaka; E. Kubota; S. Yano; T. Joh JOURNAL OF GASTROENTEROLOGY AN...See More
H. Kataoka; N. Hayashi; E. Kubota; M. Tanaka; S. Yano; Y. Sakai; T. Joh EUROPEAN JOURNAL OF CANCER 51- S63 -S64 2015/09
Cancer cell specific and selective photodynamic therapy using newly developed glucose- and oligosaccharide-conjugated chlorinsH. Kataoka; N. Hayashi; E. Kubota; M. Tanaka; S. Yano; Y. Sakai; T. Joh E...See More
Effectiveness of combination therapy with adalimumab plus intensive granulocyte and monocyte adsorptive apheresis in patients with crohn's diseaseKeiji Ozeki; Satoshi Tanida; Tsutomu Mizoshita; Hirono...See More
Immunogenic Death of Cells Treated with New Photodynamic Therapy (PDT) with Glucose-Conjugated Chlorin (G-Chlorin)Mamoru Tanaka; Hiromi Kataoka; Joh Takashi DIGESTIVE DISEASES AND SCIENCES 59- (9) ...See More
H. Kataoka; S. Hamano; M. Aoyama; Y. Mori; M. Tanaka; N. Hayashi; E. Kubota; R. Johnston; T. Joh EUROPEAN JOURNAL OF CANCER 50- S183 -S183 2014/07
Enhanced antitumor effects of oncolytic reovirus and trastuzumab combination therapy in human HER2-positive gastric cancerH. Kataoka; S. Hamano; M. Aoyama; Y. Mori; M. Tanaka; N. Hayashi; E. Kubota; R...See More
Development of Novel Therapy for Gastric Cancer Using Oncolytic ReovirusYoshinori Mori; Hiromi Kataoka; Mamoru Tanaka; Masahide Ebi; Tsutomu Mizoshita; Satoshi Tanida; Takeshi Kamiya; Randal N. Johnst...See More
Antitumor Effect of a New Glycoconjugated Platinum (II) Complex and a New Glycoconjugated Palladium (II) Complex for Cddp-Resistant Gastric CancerMamoru Tanaka; Hiromi Kataoka; Takashi Joh GASTROENTE...See More
The Efficacy of Photodynamic Therapy With a Novel Photosensitizer, Glycoconjugated Chlorin for Stomach and Colon CancerMamoru Tanaka; Hiromi Kataoka; Takashi Joh GASTROENTEROLOGY 140- (5) S682 -S...See More
M. Tanaka; H. Kataoka; M. Yoshida; T. Shimura; A. Morita; S. Yano; T. Joh ANNALS OF ONCOLOGY 21- 49 -49 2010/10
THE DEVELOPMENT OF THE NOVEL PHOTODYNAMIC THERAPY WITH GLYCOCONJUGATED CHLORINE FOR STOMACH AND COLON CANCERM. Tanaka; H. Kataoka; M. Yoshida; T. Shimura; A. Morita; S. Yano; T. Joh ANNALS OF ONCOLOG...See More
Takashi Mizushima; Makoto Sasaki; Tomoaki Ando; Tsuneya Wada; Mamoru Tanaka; Yasuyuki Okamoto; Masahide Ebi; Yosikazu Hirata; Kenji Murakami; Tsutomu Mizoshita; Takaya Shimura; Eiji Kubota; Naotaka Ogasawara; Satoshi Tanida; Hiromi Kataoka; Takeshi Kamiya; J. S. Alexander; Takashi Joh AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 298- (2) G255 -G266 2010/02
Blockage of angiotensin II type 1 receptor regulates TNF-alpha-induced MAdCAM-1 expression via inhibition of NF-kappa B translocation to the nucleus and ameliorates colitisTakashi Mizushima; Makoto Sa...See More
The Blockage of Angiotensin II Type 1 Receptor Regulated Cytokine Induced MADCAM-1 Expression By Preventing the NF-kappa B Binding Activity in Nucleus and Ameliorates ColitisTakashi Mizushima; Makoto ...See More
IL-8-Induced Colon Cancer Proliferation Through Trafficking of C-Terminal HB-EGF Into Nucleus As a New MechanismSatoshi Tanida; Hiromi Kataoka; Makoto Sasaki; Eiji Kubota; Tsuneya Wada; Tsutomu Mizosh...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2023/04 -2026/03
Author : 田中 守; 佐々木 槙子; 片岡 洋望
Synergistic effect of the combination therapy of photodynamic therapy and ferotosis inducerJapan Society for the Promotion of Science:Grants-in-Aid for Scientific ResearchDate (from‐to) : 2023/04 -20...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2018/04 -2021/03
Author : Hayashi Noriyuki
Elucidation of mechanisms underlying angiogenesis is important for the development of new anti-angiogenic drugs. Here, we found that EIF3D, a critical translational factor, is ubiquitinated by the cullin-3 (CUL3)/KCTD10 ubiquitin ligase complex in both endothelial cells and hepatocellular carcinoma cells. Knockdown of EIF3D in endothelial cells drastically inhibited tube formation of endothelial cells, that mimics angiogenesis in vitro. Our results suggest that CUL3/KCTD10/EIF3D would be a promising target for development of novel anti-angiogenic drugs.
Elucidation of mechanisms underlying angiogenesis is important for the development of new anti-angiogenic drugsJapan Society for the Promotion of Science:Grants-in-Aid for Scientific ResearchDate (fro...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2018/04 -2021/03
Author : Hayashi Noriyuki
Elucidation of mechanisms underlying angiogenesis is important for the development of new anti-angiogenic drugs. Here, we found that EIF3D, a critical translational factor, is ubiquitinated by the cullin-3 (CUL3)/KCTD10 ubiquitin ligase complex in both endothelial cells and hepatocellular carcinoma cells. Knockdown of EIF3D in endothelial cells drastically inhibited tube formation of endothelial cells, that mimics angiogenesis in vitro. Our results suggest that CUL3/KCTD10/EIF3D would be a promising target for development of novel anti-angiogenic drugs.
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2017/04 -2021/03
Author : Mamoru Tanaka
PARP inhibitors are drugs that induce cell death by synthetic lethality, and are attracting attention as next-generation antitumor drugs due to their "excellent tumor selectivity" and "low toxicity", but the effect of the single agent is not sufficient. So, it is necessary to consider more effective treatment methods. We have reported that temozolomide (TMZ) is a candidate for a concomitant drug with a PARP inhibitor and its synergistic effect. In addition, the effects of MGMT expression and MSI susceptibility on TMZ monotherapy have been reported. In this study, we will analyze in detail the genes related to PARP inhibitors and TMZ susceptibility in colorectal cancer. We also aimed to establish clinically personalized treatment of PARP inhibitor TMZ for colorectal cancer by analyzing the expression and mutation of related genes using clinical specimens.
Genes related to anticancer drug sensitization by PARP inhibitors for colorectal cancerJapan Society for the Promotion of Science:Grants-in-Aid for Scientific ResearchDate (from‐to) : 2017/04 -2021/0...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2017/04 -2021/03
Author : Mamoru Tanaka
PARP inhibitors are drugs that induce cell death by synthetic lethality, and are attracting attention as next-generation antitumor drugs due to their "excellent tumor selectivity" and "low toxicity", but the effect of the single agent is not sufficient. So, it is necessary to consider more effective treatment methods. We have reported that temozolomide (TMZ) is a candidate for a concomitant drug with a PARP inhibitor and its synergistic effect. In addition, the effects of MGMT expression and MSI susceptibility on TMZ monotherapy have been reported. In this study, we will analyze in detail the genes related to PARP inhibitors and TMZ susceptibility in colorectal cancer. We also aimed to establish clinically personalized treatment of PARP inhibitor TMZ for colorectal cancer by analyzing the expression and mutation of related genes using clinical specimens.
Photodynamic therapy (PDT) using mannose-conjugated chlorin (M-chlorin) designed to target tumor-associated macrophages (TAMs) in cancer stroma (which express high level of mannose receptors) showed very strong cytotoxicity against not only TAMs but also cancer cells. We also synthesized oligosaccharide-conjugated chlorin (O-chlorin) with improved water-solubility. O-chlorin showed very excellent photodynamic diagnosis effects as well as PDT effects.
Development of a novel photodynamic therapy with sugar-conjugated chlorin targeting tumor-associated macrophages in cancer stroma.Japan Society for the Promotion of Science:Grants-in-Aid for Scientifi...See More
Photodynamic therapy (PDT) using mannose-conjugated chlorin (M-chlorin) designed to target tumor-associated macrophages (TAMs) in cancer stroma (which express high level of mannose receptors) showed very strong cytotoxicity against not only TAMs but also cancer cells. We also synthesized oligosaccharide-conjugated chlorin (O-chlorin) with improved water-solubility. O-chlorin showed very excellent photodynamic diagnosis effects as well as PDT effects.
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2014/04 -2017/03
Author : TANAKA Mamoru
Photodynamic therapy (PDT) consists of the administration of a photosensitizer together with visible light irradiation at a specific wavelength to activate the photosensitizer, leading to the conversion of molecular oxygen to various highly reactive oxygen species (ROS), which either kill tumor cells directly or damage the tumor- associated vasculature. G-chlorin (glycoconjugated chlorin; glucose-linked tetra (fluorophenyl) chlorin) has been developed as a new type of photosensitizer. In the current study, we show that PDT with a new photosensitizer, G-chlorin
The mechanism of new photodynamic therapy targeting cancer stem cell with glycoconjugated chlorinJapan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2014/04 -2017/03
Author : TANAKA Mamoru
Photodynamic therapy (PDT) consists of the administration of a photosensitizer together with visible light irradiation at a specific wavelength to activate the photosensitizer, leading to the conversion of molecular oxygen to various highly reactive oxygen species (ROS), which either kill tumor cells directly or damage the tumor- associated vasculature. G-chlorin (glycoconjugated chlorin; glucose-linked tetra (fluorophenyl) chlorin) has been developed as a new type of photosensitizer. In the current study, we show that PDT with a new photosensitizer, G-chlorin
新規光線力学的療法のHigh-Mobility Group Box-1 (HMGB1)と Calreticulin(CRT)を介した腫瘍抑制効果のメカニズムの解析
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2012/04 -2015/03
Author : TANAKA MAMORU
Both the pre-apoptotic exposure to calreticulin (CRT) and the post-apoptotic release of high-mobility group box 1 protein (HMGB1) are required for immunogenic cell death. Photodynamic therapy (PDT) uses non-toxic photosensitizers and visible light at a specific wavelength in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumor microvasculature, and stimulate the host immune system. We have previously shown that glucose-conjugated chlorin (G-chlorin) had superior cancer cell selectivity, and it effectively suppressed the growth of xenograft tumors. In this study, we evaluated the immunogenicity of PDT with G-chlorin treatment in colon cancer cells.
Immunogenic death of cells treated with new photodynamic therapy (PDT) with glucose-conjugated chlorin (G-chlorin)Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2012/04 -2015/03
Author : TANAKA MAMORU
Both the pre-apoptotic exposure to calreticulin (CRT) and the post-apoptotic release of high-mobility group box 1 protein (HMGB1) are required for immunogenic cell death. Photodynamic therapy (PDT) uses non-toxic photosensitizers and visible light at a specific wavelength in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumor microvasculature, and stimulate the host immune system. We have previously shown that glucose-conjugated chlorin (G-chlorin) had superior cancer cell selectivity, and it effectively suppressed the growth of xenograft tumors. In this study, we evaluated the immunogenicity of PDT with G-chlorin treatment in colon cancer cells.
Except for surgical resection, no effective treatment strategies have been established for gastrointestinal stromal tumors (GISTs). Photodynamic therapy (PDT) consists of intravenous administration of a photosensitizer, activated by a specific wavelength of light, which produces reactive oxygen species that directly kill tumor cells. We analyzed the efficacy of PDT using a newly developed photosensitizer, glucose-conjugated chlorin (G-chlorin) for the GIST treatment. In vitro, the expression of the glucose transporters GLUT1, GLUT3, and GLUT4, the cellular uptake of G-chlorin, and apoptosis mediated by PDT with G-chlorin were significantly higher in GIST-T1 than in WI-38 cells. In vivo, G-chlorin accumulation was higher in xenograft tumors of GIST-T1 cells than in the adjacent normal tissue, and tumor growth was significantly suppressed following PDT.
Development of novel PDT with glucose-conjugated chlorin for gastric cancer and GISTJapan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Researc...See More
Except for surgical resection, no effective treatment strategies have been established for gastrointestinal stromal tumors (GISTs). Photodynamic therapy (PDT) consists of intravenous administration of a photosensitizer, activated by a specific wavelength of light, which produces reactive oxygen species that directly kill tumor cells. We analyzed the efficacy of PDT using a newly developed photosensitizer, glucose-conjugated chlorin (G-chlorin) for the GIST treatment. In vitro, the expression of the glucose transporters GLUT1, GLUT3, and GLUT4, the cellular uptake of G-chlorin, and apoptosis mediated by PDT with G-chlorin were significantly higher in GIST-T1 than in WI-38 cells. In vivo, G-chlorin accumulation was higher in xenograft tumors of GIST-T1 cells than in the adjacent normal tissue, and tumor growth was significantly suppressed following PDT.