Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2017/04 -2020/03
Author : Shamoto Tomoya
Xanthohumol, a natural compound derived from hops and having a strong anti-inflammatory effect, suppressed NF-κB at a low dose in pancreatic cancer and suppressed the expression and production of the angiogenic factors VEGF-A and IL-8 downstream thereof. Furthermore, in vitro, xanthohumol actually suppressed HUVEC angiogenesis. In addition, xanthohumol also has an antitumor effect on pancreatic cancer in vivo using pancreatic cancer subcutaneous transplantation model mice, and immunostaining of the tumor caused a decrease in micro vessel density and the expression of Ki-67, p65, VEGF, IL-8. For VEGF and IL-8, quantitative evaluation by PCR was also performed, and a decrease in expression was confirmed.