Researchers Database

TAKAKUWA Osamu

    Professor
Contact: takakuwamed.nagoya-cu.ac.jp
Last Updated :2024/04/26

Researcher Information

J-Global ID

Research Interests

  • 医学教育   呼吸器内視鏡検査   肺癌化学療法   癌緩和医療   

Research Areas

  • Life sciences / Respiratory medicine

Published Papers

MISC

Research Grants & Projects

  • 日本学術振興会:科学研究費助成事業
    Date (from‐to) : 2022/04 -2026/03 
    Author : 高桑 修; 柿崎 真沙子; 松尾 洋一; 山下 純世; 小林 成美
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
    Date (from‐to) : 2015/04 -2018/03 
    Author : Tetsuya Oguri; KUNII Eiji; FUKUDA Satoshi; Sone Kazuki
     
    We established platinum drug-resistant lung cancer cell lines and found that the intracellular platinum concentration was decreased concomitantly with decreased organic cation transporter 6 (OCT6) expression in the platinum-drug resistant cell lines. The present findings indicate that OCT6 is directly involved in platinum drug resistance by mediating platinum drug uptake in cancer cells. Then we focused on a functional single nucleotide polymorphism (SNP) of OCT6. We retrospectively examined the relationship between the efficacy of cisplatin and OCT6 SNP in non-small lung cancer patients. We found that progression free survival was significantly different depending on OCT6 SNP. This OCT6 SNP has shown influenced on doxorubicin pharmacokinetics, therefore we are now going to investigate the influence of OCT6 SNP for another anthracycline derivative, amrubicin.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
    Date (from‐to) : 2013/04 -2016/03 
    Author : Takakuwa Osamu
     
    Aim of this study is to find a clinical biomarker for amrubicin treatment and its mechanism. We found that polymorphisms of ABCB1 have relationship with amrubicin-induced neutropenia. Also, we had a result that area under the plasma concentration versus time curve (AUC) values of amrubicinol have a significant relation with grade of neutropenia during amrubicin treatment. However, we could not reach to identify the factor which regulates AUC value of amrubicinol. We now focus on organic cation transporter (OCT) and have continued to investigate factors which regulate pharmacological function of amrubicin.

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