Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
Date (from‐to) : 2011 -2013
Author : YUMOTO Eiji; SANUKI Tetsuji; KUMAI Yoshihiko
Two animal groups were made: denervation (DNV) and reinnervation (Suture) groups. DNV animals did not show vocal fold movement. Some of Suture group animals showed synkinesis and others in the group showed weak physiological movement during respiration. Greater electromyographic recruitment of TA than PCA was seen during inhalation in the former, while recruitment of PCA was greater than TA during inhalation in majority of the latter subgroup.
Aberrant regeneration of nerve fibers in Suture group may have occurred, resulting in synkinesis of the VF depending on the degree of misdirection. Appearance of myosin heavy chain type IIA was not associated with the presence of synkinesis. Administration of Ca channel inhibitor, which facilitates axonal extension during regeneration, in Suture group did not result in decrease of synkinesis.