KIMURA Hiroaki

Researcher Information

J-Global ID

• 202001007562748289

Research Interests

• musculoskeletal tumor   Bone metastasis   

Research Areas

• Life sciences / Orthopedics / musculoskeletal tumor

Academic & Professional Experience

• 2020/10 - Today  Nagoya City UniversityGraduate School of Medical Sciences Department of Orthopedic Surgery講師
• 2016/04 - 2020/10  Kanazawa RedCross HospitalOrthopedic Surgery第一整形外科部長
• 2014/04 - 2016/03  Nagoya City UniversityGraduate School of Medical Sciences Department of Orthopedic Surgery病院講師
• 2011/09 - 2014/03  Kanazawa UniversityOrthopedic Surgery助教
• 2010/06 - 2011/08  Kanazawa UniversityOrthopedic Surgery医員
• 2008/02 - 2010/06  University of California, San DiegoSurgeryポスドク

Education

• 2002/04 - 2011/03  Kanazawa University  Graduate School of Medical Science
• 1996/04 - 2002/03  Kanazawa University  医学部  医学科

Published Papers

• Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts.

  Sei Morinaga; Qinghong Han; Yutaro Kubota; Kohei Mizuta; Byung Mo Kang; Motokazu Sato; Michael Bouvet; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Takashi Higuchi; Hiroyuki Tsuchiya; Robert M Hoffman

  Anticancer research 44 (3) 921 - 928 2024/03
• Special Issue: "Pediatric Orthopedic Malignancy: Types, Symptoms, and Treatment".

  Hisaki Aiba; Shinji Miwa; Hideki Murakami; Hiroaki Kimura

  Children (Basel, Switzerland) 10 (9) 2023/09
• Protocol for a randomized study of the efficacy of ibandronic acid plus eldecalcitol in patients with gastric cancer after gastrectomy: A comparative study of different routes of administration of ibandronic acid

  Hisaki Aiba; Nobuyuki Suzuki; Hiroyuki Sagawa; Hiroya Hashimoto; Hiroaki Kimura; Jumpei Inoue; Takuya Usami; Yuta Goto; Yuichiro Mizuno; Tomotaka Okubo; Sunao Ito; Shuji Takiguchi; Hideki Murakami

  F1000Research F1000 Research Ltd 11 796 - 796 2022/07
• Management of Soft-tissue Tumors With a Size of 2-5 cm, Including Malignancy.

  Yoshihiro Araki; Norio Yamamoto; Toru Maeda; Hiroaki Kimura; Takashi Ota; Shingo Shimozaki; Takashi Kato; Daisuke Inoue; Takashi Higuchi; Kensaku Abe; Yuta Taniguchi; Hiroyuki Tsuchiya

  Anticancer research 42 (3) 1555 - 1562 2022/03
• Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application.

  Takashi Higuchi; Kentaro Igarashi; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Michael Bouvet; Hiroyuki Tsuchiya; Robert M Hoffman

  Frontiers in oncology 12 957844 - 957844 2022
• Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review.

  Takashi Higuchi; Kentaro Igarashi; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Michael Bouvet; Hiroyuki Tsuchiya; Robert M Hoffman

  Anticancer research 41 (12) 5865 - 5871 2021/12
• Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation

  Hiroaki Kimura; Norio Yamamoto; Katsuhiro Hayashi; Takashi Higuchi; Hiroyuki Tsuchiya

  Case Reports in Oncology S. Karger AG 14 (3) 1490 - 1496 2021/10
• Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study.

  Hisaki Aiba; Kunihiro Ikuta; Kunihiro Asanuma; Katsuhisa Kawanami; Satoshi Tsukushi; Akihiko Matsumine; Daisuke Ishimura; Akihito Nagano; Yoji Shido; Eiji Kozawa; Kenji Yamada; Junji Wasa; Hiroaki Kimura; Takao Sakai; Hideki Murakami; Tomohisa Sakai; Tomoki Nakamura; Yoshihiro Nishida

  Cancers 13 (15) 2021/08
• Significant Improvement After Surgery for a Symptomatic Osteoblastoma in a Patient with Camurati-Engelmann Disease: Case Report and Literature Review.

  Hirotaka Yonezawa; Katsuhiro Hayashi; Norio Yamamoto; Akihiko Takeuchi; Kaoru Tada; Shinji Miwa; Kentaro Igarashi; Hiroaki Kimura; Yu Aoki; Sei Morinaga; Yoshihiro Araki; Yohei Asano; Keisuke Sakurakichi; Hiroko Ikeda; Takayuki Nojima; Hiroyuki Tsuchiya

  Calcified tissue international 108 (6) 819 - 824 2021/06
• Myelolipoma mimicking osteosarcoma in the distal femur.

  Takao Sakai; Hisaki Aiba; Motoo Nakagawa; Hideo Hattori; Hideki Murakami; Hiroaki Kimura

  International journal of surgery case reports 83 105997 - 105997 2021/06
• Combination methionine-methylation-axis blockade: A novel approach to target the methionine addiction of cancer

  Takashi Higuchi; Qinghong Han; Norihiko Sugisawa; Jun Yamamoto; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M. Hoffman

  Cancer Genomics and Proteomics 18 (2) 113 - 120 1109-6535 2021/04
• Correction to: Treatment strategy for atypical ulnar fracture due to severely suppressed bone turnover caused by long-term bisphosphonate therapy: a case report and literature review.

  Kensaku Abe; Hiroaki Kimura; Norio Yamamoto; Shingo Shimozaki; Takashi Higuchi; Yuta Taniguchi; Takaaki Uto; Hiroyuki Tsuchiya

  BMC musculoskeletal disorders 22 (1) 9 - 9 2021/01
• Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib

  TAKASHI HIGUCHI; KENTARO IGARASHI; NORIO YAMAMOTO; KATSUHIRO HAYASHI; HIROAKI KIMURA; SHINJI MIWA; MICHAEL BOUVET; HIROYUKI TSUCHIYA; ROBERT M. HOFFMAN

  Cancer Genomics - Proteomics Anticancer Research USA Inc. 18 (5) 637 - 643 1109-6535 2021
• Different patterns of pneumothorax in patients with soft tissue tumors treated with pazopanib: A case series analysis.

  Hisaki Aiba; Hiroaki Kimura; Satoshi Yamada; Hideki Okamoto; Katsuhiro Hayashi; Shinji Miwa; Yohei Kawaguchi; Shiro Saito; Takao Sakai; Tsutomu Tatematsu; Ryoichi Nakanishi; Hideki Murakami

  PloS one 16 (7) e0254866  2021
• Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review.

  Hirotaka Yonezawa; Norio Yamamoto; Katsuhiro Hayashi; Akihiko Takeuchi; Shinji Miwa; Kentaro Igarashi; Mickhael Bang Langit; Hiroaki Kimura; Shingo Shimozaki; Takashi Kato; Sei Morinaga; Yoshihiro Araki; Yohei Asano; Hiroko Ikeda; Takayuki Nojima; Hiroyuki Tsuchiya

  BMC musculoskeletal disorders 21 (1) 836 - 836 2020/12
• Treatment strategy for atypical ulnar fracture due to severely suppressed bone turnover caused by long-term bisphosphonate therapy: a case report and literature review.

  Kensaku Abe; Hiroaki Kimura; Norio Yamamoto; Shingo Shimozaki; Takashi Higuchi; Yuta Taniguchi; Takaaki Uto; Hiroyuki Tsuchiya

  BMC musculoskeletal disorders 21 (1) 802 - 802 2020/12
• Osimertinib regressed an EGFR-mutant lung-adenocarcinoma bone-metastasis mouse model and increased long-term survival.

  Takashi Higuchi; Norihiko Sugisawa; Jun Ho Park; Yu Sun; Guangwei Zhu; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Translational oncology 13 (10) 100826 - 100826 2020/10
• Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis.

  Shiro Saito; Hisaki Aiba; Satoshi Yamada; Hideki Okamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Takanobu Otsuka; Hideki Murakami

  BMC cancer 20 (1) 868 - 868 2020/09
• 軟骨肉腫に対する非ステロイド性抗炎症薬によるPPARγを標的とした新しい治療戦略の可能性

  樋口 貴史; 山本 憲男; 林 克洋; 武内 章彦; 木村 浩明; 三輪 真嗣; 五十嵐 健太郎; 米澤 宏隆; 森永 整; 山本 靖彦; 土屋 弘行

  日本整形外科学会雑誌 (公社)日本整形外科学会 94 (8) S1981 - S1981 0021-5325 2020/09
• 軟部肉腫に対するolaratumabの可能性 patient-derived orthotopic xenograft(PDOX)マウスモデルによる解析

  樋口 貴史; 山本 憲男; 林 克洋; 木村 浩明; 武内 章彦; 三輪 真嗣; 五十嵐 健太郎; 米澤 宏隆; 森永 整; 荒木 麗博; 土屋 弘行

  日本整形外科学会雑誌 (公社)日本整形外科学会 94 (8) S1985 - S1985 0021-5325 2020/09
• Improvement of locomotive syndrome with surgical treatment in patients with degenerative diseases in the lumbar spine and lower extremities: a prospective cohort study.

  Satoshi Kato; Yuki Kurokawa; Tamon Kabata; Satoru Demura; Hidenori Matsubara; Yoshitomo Kajino; Yoshiyuki Okamoto; Hiroaki Kimura; Kazuya Shinmura; Kentaro Igarashi; Takaki Shimizu; Noritaka Yonezawa; Noriaki Yokogawa; Hiroyuki Tsuchiya

  BMC musculoskeletal disorders 21 (1) 515 - 515 2020/08
• Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma.

  Kentaro Igarashi; Kei Kawaguchi; Ming Zhao; Qinghong Han; Yuying Tan; Tasuku Kiyuna; Kentaro Miyake; Takashi Higuchi; Scott D Nelson; Sarah M Dry; Yunfeng Li; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Anticancer research 40 (5) 2515 - 2523 2020/05
• Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model.

  Takashi Higuchi; Qinghong Han; Kentaro Miyake; Hiromichi Oshiro; Norihiko Sugisawa; Yuying Tan; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Biochemical and biophysical research communications 523 (1) 135 - 139 2020/02
• The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model.

  Takashi Higuchi; Norihiko Sugisawa; Jun Yamamoto; Hiromichi Oshiro; Qinghong Han; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Yuying Tan; Shreya Kuchipudi; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Cancer chemotherapy and pharmacology 85 (2) 285 - 291 2020/02
• Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model.

  Kentaro Igarashi; Kei Kawaguchi; Ming Zhao; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Scott D Nelson; Sarah M Dry; Yunfeng Li; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Takashi Higuchi; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Translational oncology 13 (2) 393 - 400 2020/02
• Patient-derived orthotopic xenograft models of sarcoma.

  Kentaro Igarashi; Kei Kawaguchi; Takashi Murakami; Kentaro Miyake; Tasuku Kiyuna; Masuyo Miyake; Yukihiko Hiroshima; Takashi Higuchi; Hiromichi Oshiro; Scott D Nelson; Sarah M Dry; Yunfeng Li; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Cancer letters 469 332 - 339 2020/01
• PPARγ Agonist Pioglitazone in Combination with Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model

  Takashi Higuchi; Jun Yamamoto; Norihiko Sugisawa; Yoshihiko Tashiro; Hiroto Nishino; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Michael Bouvet; Shree R.A.M. Singh; Hiroyuki Tsuchiya; Robert M. Hoffman

  Cancer Genomics and Proteomics 17 (1) 35 - 40 1109-6535 2020
• Pioglitazone, an agonist of PPARγ, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression.

  Takashi Higuchi; Norihiko Sugisawa; Kentaro Miyake; Hiromichi Oshiro; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Zoey Kline; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 118 109356 - 109356 2019/10
• The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model.

  Takashi Higuchi; Norihiko Sugisawa; Kentaro Miyake; Hiromichi Oshiro; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Translational oncology 12 (9) 1257 - 1263 2019/09
• Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.

  Takashi Higuchi; Hiromichi Oshiro; Kentaro Miyake; Norihiko Sugisawa; Qinghong Han; Yuying Tan; Junho Park; Zhiying Zhang; Sahar Razmjooei; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Michael Bouvet; Sant P Chawla; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Anticancer research 39 (9) 4653 - 4657 2019/09
• Combination Treatment With Sorafenib and Everolimus Regresses a Doxorubicin-resistant Osteosarcoma in a PDOX Mouse Model.

  Takashi Higuchi; Norihiko Sugisawa; Kentaro Miyake; Hiromichi Oshiro; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Zoey Kline; Paige Belt; Sant P Chawla; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Anticancer research 39 (9) 4781 - 4786 2019/09
• Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model.

  Takashi Higuchi; Norihiko Sugisawa; Kentaro Miyake; Hiromichi Oshiro; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Sant P Chawla; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Anticancer research 39 (8) 4079 - 4084 2019/08
• Olaratumab combined with doxorubicin and ifosfamide overcomes individual doxorubicin and olaratumab resistance of an undifferentiated soft-tissue sarcoma in a PDOX mouse model.

  Takashi Higuchi; Kentaro Miyake; Norihiko Sugisawa; Hiromichi Oshiro; Zhiying Zhang; Sahar Razmjooei; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Cancer letters 451 122 - 127 2019/06
• The combination of olaratumab with gemcitabine and docetaxel arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft mouse model.

  Takashi Higuchi; Kentaro Miyake; Norihiko Sugisawa; Hiromichi Oshiro; Zhiying Zhang; Sahar Razmjooei; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Cancer chemotherapy and pharmacology 83 (6) 1075 - 1082 2019/06
• Pazopanib regresses a doxorubicin-resistant synovial sarcoma in a patient-derived orthotopic xenograft mouse model.

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Scott D Nelson; Tara A Russell; Sarah M Dry; Yunfeng Li; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Takashi Higuchi; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Tissue & cell 58 107 - 111 2019/06
• Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model.

  Takashi Higuchi; Kentaro Miyake; Hiromichi Oshiro; Norihiko Sugisawa; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Sant P Chawla; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Biochemical and biophysical research communications 513 (2) 326 - 331 2019/05
• Treatment of a Malignant Soft Tissue Tumor Arising in the Vicinity of the Sciatic Nerve with an In-Situ Preparation Technique and Intensive Multidisciplinary Therapy.

  Hisaki Aiba; Katsuhiro Hayashi; Satoshi Yamada; Hideki Okamoto; Hiroaki Kimura; Shinji Miwa; Hiroyuki Inatani; Takanobu Otsuka; Hideki Murakami

  Cancers 11 (4) 2019/04
• Osimertinib Regresses an EGFR-Mutant Cisplatinum- Resistant Lung Adenocarcinoma Growing in the Brain in Nude Mice.

  Takashi Higuchi; Hiromichi Oshiro; Zhiying Zhang; Kentaro Miyake; Norihiko Sugisawa; Yuki Katsuya; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Ming Zhao; Michael Bouvet; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Translational oncology 12 (4) 640 - 645 2019/04
• The combination of gemcitabine and nab-paclitaxel as a novel effective treatment strategy for undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.

  Takashi Higuchi; Kei Kawaguchi; Kentaro Miyake; Hiromichi Oshiro; Zhiying Zhang; Sahar Razmjooei; Sintawat Wangsiricharoen; Kentaro Igarashi; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Scott D Nelson; Sarah M Dry; Yunfeng Li; Sant P Chawla; Frederick C Eilber; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 111 835 - 840 2019/03
• A prospective clinical trial to assess the accuracy of an MRI-based patient-specific acetabular instrument guide in total hip arthroplasty.

  Daisuke Inoue; Tamon Kabata; Hiroaki Kimura; Hiroyuki Tsuchiya

  European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 29 (1) 65 - 71 2019/01
• Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma.

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyaki; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Takashi Higuchi; Arun S Singh; Bartosz Chmielowski; Scott D Nelson; Tara A Russell; Mark A Eckardt; Sarah M Dry; Yunfeng Li; Shree Ram Singh; Sant P Chawla; Fritz C Eilber; Hiroyuki Tsuchiya; Robert M Hoffman

  Biochemical and biophysical research communications 506 (4) 912 - 917 2018/12
• Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model.

  Takashi Higuchi; Kei Kawaguchi; Kentaro Miyake; Qinghong Han; Yuying Tan; Hiromichi Oshiro; Norihiko Sugisawa; Zhiying Zhang; Sahar Razmjooei; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Sant P Chawla; Arun S Singh; Frederick C Eilber; Shree Ram Singh; Hiroyuki Tsuchiya; Robert M Hoffman

  Anticancer research 38 (10) 5639 - 5644 2018/10
• Temozolomide regresses a doxorubicin-resistant undifferentiated spindle-cell sarcoma patient-derived orthotopic xenograft (PDOX): precision-oncology nude-mouse model matching the patient with effective therapy

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Yunfeng Li; Scott D. Nelson; Sarah M. Dry; Arun S. Singh; Irmina A. Elliott; Tara A. Russell; Mark A. Eckardt; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  Journal of Cellular Biochemistry Wiley-Liss Inc. 119 (8) 6598 - 6603 1097-4644 2018/08 [Refereed]
  
• Growth of epiphysis after epiphyseal-preservation surgery for childhood osteosarcoma around the knee joint.

  Akihiko Takeuchi; Norio Yamamoto; Katsuhiro Hayashi; Hidenori Matsubara; Hiroaki Kimura; Shinji Miwa; Takashi Higuchi; Kensaku Abe; Yuta Taniguchi; Hiroyuki Tsuchiya

  BMC musculoskeletal disorders 19 (1) 185 - 185 2018/06
• Treatment outcomes of the simple bone cyst

  Takashi Higuchi; Norio Yamamoto; Toshiharu Shirai; Katsuhiro Hayashi; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Kensaku Abe; Yuta Taniguchi; Hiroyuki Tsuchiya

  Medicine (United States) Lippincott Williams and Wilkins 97 (18) e0572  1536-5964 2018/05 [Refereed]
  
• Mid- to long-term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization

  Akihiko Takeuchi; Prakrit Suwanpramote; Norio Yamamoto; Toshiharu Shirai; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Takashi Higuchi; Kensaku Abe; Hiroyuki Tsuchiya

  Journal of Surgical Oncology John Wiley and Sons Inc. 117 (6) 1232 - 1238 1096-9098 2018/05 [Refereed]
  
• Calcium phosphate cement in the surgical management of benign bone tumors

  Takashi Higuchi; Norio Yamamoto; Katsuhiro Hayashi; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Kensaku Abe; Yuta Taniguchi; Hisaki Aiba; Hiroyuki Tsuchiya

  Anticancer Research International Institute of Anticancer Research 38 (5) 3031 - 3035 1791-7530 2018/05 [Refereed]
  
• Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.

  Takashi Higuchi; Akihiko Takeuchi; Seiichi Munesue; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Inatani; Shingo Shimozaki; Takashi Kato; Yu Aoki; Kensaku Abe; Yuta Taniguchi; Hisaki Aiba; Hideki Murakami; Ai Harashima; Yasuhiko Yamamoto; Hiroyuki Tsuchiya

  Cancer medicine 7 (5) 1944 - 1954 2018/05 [Refereed]
  
• Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model

  Kentaro Igarashi; Kei Kawaguchi; Shukuan Li; Qinghong Han; Yuying Tan; Emily Gainor; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Takashi Higuchi; Hiromichi Oshiro; Arun S. Singh; Mark A. Eckardt; Scott D. Nelson; Tara A. Russell; Sarah M. Dry; Yunfeng Li; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  Oncotarget Impact Journals LLC 9 (27) 19263 - 19272 1949-2553 2018/04 [Refereed]
  
• Preoperative evaluation of the efficacy of radio-hyperthermo-chemotherapy for soft tissue sarcoma in a case series

  Hisaki Aiba; Satoshi Yamada; Jun Mizutani; Norio Yamamoto; Hideki Okamoto; Katsuhiro Hayashi; Hiroaki Kimura; Akihiko Takeuchi; Shinji Miwa; Takashi Higuchi; Kensaku Abe; Yuta Taniguchi; Yoshihiro Araki; Hiroyuki Tsuchiya; Takanobu Otsuka

  PLoS ONE Public Library of Science 13 (4) e0195289  1932-6203 2018/04 [Refereed]
  
• Clinical outcomes of radio-hyperthermo-chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched-pair cohort study

  Hisaki Aiba; Satoshi Yamada; Jun Mizutani; Norio Yamamoto; Hideki Okamoto; Katsuhiro Hayashi; Hiroaki Kimura; Akihiko Takeuchi; Shinji Miwa; Akira Kawai; Kenichi Yoshimura; Hiroyuki Tsuchiya; Takanobu Otsuka

  Cancer Medicine Blackwell Publishing Ltd 7 (4) 1560 - 1571 2045-7634 2018/04 [Refereed]
  
• Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase

  Kentaro Igarashi; Shukuan Li; Qinghong Han; Yuying Tan; Kei Kawaguchi; Takashi Murakami; Tasuku Kiyuna; Kentaro Miyake; Yunfeng Li; Scott D. Nelson; Sarah M. Dry; Arun S. Singh; Irmina A. Elliott; Tara A. Russell; Mark A. Eckardt; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  Journal of Cellular Biochemistry Wiley-Liss Inc. 119 (4) 3537 - 3544 1097-4644 2018/04 [Refereed]
  
• Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma

  Kentaro Igarashi; Kei Kawaguchi; Shukuan Li; Qinghong Han; Yuying Tan; Takashi Murakami; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Arun S. Singh; Mark A. Eckardt; Scott D. Nelson; Tara A. Russell; Sarah M. Dry; Yunfeng Li; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Shree Ram Singh; Fritz C. Eilber; Robert M. Hoffman

  Cancer Letters Elsevier Ireland Ltd 417 168 - 173 1872-7980 2018/03 [Refereed]
  
• Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Shukuan Li; Qinghong Han; Yuying Tan; Ming Zhao; Yunfeng Li; Scott D. Nelson; Sarah M. Dry; Arun S. Singh; Irmina A. Elliott; Tara A. Russell; Mark A. Eckardt; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  Cell Cycle Taylor and Francis Inc. 17 (6) 801 - 809 1551-4005 2018/03 [Refereed]
  
• Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Arun S. Singh; Mark A. Eckardt; Scott D. Nelson; Tara A. Russell; Sarah M. Dry; Yunfeng Li; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Shree Ram Singh; Fritz C. Eilber; Robert M. Hoffman

  Biochemical and Biophysical Research Communications Elsevier B.V. 497 (4) 1055 - 1061 1090-2104 2018/03 [Refereed]
  
• Temozolomide combined with irinotecan regresses a cisplatinumresistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Yunfeng Li; Scott D. Nelson; Sarah M. Dry; Arun S. Singh; Irmina A. Elliott; Tara A. Russell; Mark A. Eckardt; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  Oncotarget Impact Journals LLC 9 (8) 7774 - 7781 1949-2553 2018 [Refereed]
  
• Knee joint preservation surgery in osteosarcoma using tumour-bearing bone treated with liquid nitrogen

  Takashi Higuchi; Norio Yamamoto; Hideji Nishida; Katsuhiro Hayashi; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Inatani; Shingo Shimozaki; Takashi Kato; Yu Aoki; Kensaku Abe; Yuta Taniguchi; Hiroyuki Tsuchiya

  INTERNATIONAL ORTHOPAEDICS SPRINGER 41 (10) 2189 - 2197 0341-2695 2017/10 [Refereed]
  
• Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Takashi Murakami; Shinji Miwa; Scott D. Nelson; Sarah M. Dry; Yunfeng Li; Arun S. Singh; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  ONCOTARGET IMPACT JOURNALS LLC 8 (44) 75874 - 75880 1949-2553 2017/09 [Refereed]
  
• A novel anionic-phosphate-platinum complex effectively targets an undifferentiated pleomorphic sarcoma better than cisplatinum and doxorubicin in a patient-derived orthotopic xenograft (PDOX)

  Kentaro Igarashi; Kei Kawaguchi; Takashi Murakami; Tasuku Kiyuna; Kentaro Miyake; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Scott D. Nelson; Sarah M. Dry; Yunfeng Li; Arun S. Singh; Shinji Miwa; Akira Odani; Fritz C. Eilber; Hiroyuki Tsuchiya; Robert M. Hoffman

  ONCOTARGET IMPACT JOURNALS LLC 8 (38) 63353 - 63359 1949-2553 2017/09 [Refereed]
  
• High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model

  Kentaro Igarashi; Kei Kawaguchi; Takashi Murakami; Tasuku Kiyuna; Kentaro Miyake; Arun S. Singh; Scott D. Nelson; Sarah M. Dry; Yunfeng Li; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  JOURNAL OF CELLULAR BIOCHEMISTRY WILEY 118 (9) 2739 - 2743 0730-2312 2017/09 [Refereed]
  
• Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Takashi Murakami; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Robert M. Hoffman

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 37 (9) 4807 - 4812 0250-7005 2017/09 [Refereed]
  
• Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Takashi Murakami; Shinji Miwa; Scott D. Nelson; Sarah M. Dry; Yunfeng Li; Arun S. Singh; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 37 (8) 4081 - 4084 0250-7005 2017/08 [Refereed]
  
• Do Mesenchymal Stem Cells Derived From Atypical Lipomatous Tumors Have Greater Differentiation Potency Than Cells From Normal Adipose Tissues?

  Hiroyuki Inatani; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Akihiko Takeuchi; Shinji Miwa; Takashi Higuchi; Kensaku Abe; Yuta Taniguchi; Satoshi Yamada; Kiyofumi Asai; Takanobu Otsuka; Hiroyuki Tsuchiya

  CLINICAL ORTHOPAEDICS AND RELATED RESEARCH SPRINGER 475 (6) 1693 - 1701 0009-921X 2017/06 [Refereed]
  
• An unusual case of proximal humeral simple bone cyst in an adult from secondary cystic change

  Mamer S. Rosario; Norio Yamamoto; Katsuhiro Hayashi; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Takashi Higuchi; Hiroyuki Inatani; Kensaku Abe; Yuta Taniguchi; Hisaki Aiba; Hiroyuki Tsuchiya

  WORLD JOURNAL OF SURGICAL ONCOLOGY BIOMED CENTRAL LTD 15 (1) 102  1477-7819 2017/05 [Refereed]
  
• Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Takashi Murakami; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Robert M. Hoffman

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 37 (3) 1005 - 1011 0250-7005 2017/03 [Refereed]
  
• Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model

  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Takashi Murakami; Shinji Miwa; Scott D. Nelson; Sarah M. Dry; Yunfeng Li; Arun Singh; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  CELL CYCLE TAYLOR & FRANCIS INC 16 (1) 91 - 94 1538-4101 2017 [Refereed]
  
• Intra-arterial administration of tumor-targeting Salmonella typhimurium A1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model

  Kentaro Igarashi; Kei Kawaguchi; Takashi Murakami; Tasuku Kiyuna; Kentaro Miyake; Scott D. Nelson; Sarah M. Dry; Yunfeng Li; Jane Yanagawa; Tara A. Russell; Arun S. Singh; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C. Eilber; Robert M. Hoffman

  CELL CYCLE TAYLOR & FRANCIS INC 16 (12) 1164 - 1170 1538-4101 2017 [Refereed]
  
• Clinical Outcome of Reconstruction Using Frozen Autograft for a Humeral Bone Tumor

  Hiroaki Kimura; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Yoshikazu Tanzawa; Akihiko Takeuchi; Shinji Miwa; Hiroyuki Tsuchiya

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 36 (12) 6631 - 6635 0250-7005 2016/12 [Refereed]
  
• Surgical management of proximal fibular tumors: A report of 12 cases

  Hiroyuki Inatani; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Akihiko Takeuchi; Shinji Miwa; Takashi Higuchi; Kensaku Abe; Yuta Taniguchi; Satoshi Yamada; Hideki Okamoto; Takanobu Otsuka; Hiroyuki Tsuchiya

  JOURNAL OF BONE ONCOLOGY ELSEVIER SCIENCE BV 5 (4) 163 - 166 2212-1366 2016/11 [Refereed]
  
• Real-Time In Vivo Confocal Fluorescence Imaging of Prostate Cancer Bone-Marrow Micrometastasis Development at the Cellular Level in Nude Mice

  Shinji Miwa; Makoto Toneri; Kentaro Igarashi; Shuya Yano; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Hiroyuki Tsuchiya; Robert M. Hoffman

  JOURNAL OF CELLULAR BIOCHEMISTRY WILEY-BLACKWELL 117 (11) 2533 - 2537 0730-2312 2016/11 [Refereed]
  
• Efficacy of glycogen synthase kinase-3 beta targeting against osteosarcoma via activation of beta-catenin

  Shingo Shimozaki; Norio Yamamoto; Takahiro Domoto; Hideji Nishida; Katsuhiro Hayashi; Hiroaki Kimura; Akihiko Takeuchi; Shinji Miwa; Kentaro Igarashi; Takashi Kato; Yu Aoki; Takashi Higuchi; Mayumi Hirose; Robert M. Hoffman; Toshinari Minamoto; Hiroyuki Tsuchiya

  Oncotarget IMPACT JOURNALS LLC 7 (47) 77038 - 77051 1949-2553 2016/11 [Refereed]
  
• Non-toxic Efficacy of the Combination of Caffeine and Valproic Acid on Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models

  Kentaro Igarashi; Norio Yamamoto; Katsuhiro Hayashi; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Robert M. Hoffman; Hiroyuki Tsuchiya

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 36 (9) 4477 - 4482 0250-7005 2016/09 [Refereed]
  
• The outcomes of reconstruction using frozen autograft combined with iodine-coated implants for malignant bone tumors: compared with non-coated implants

  Toshiharu Shirai; Hiroyuki Tsuchiya; Ryu Terauchi; Shinji Tsuchida; Naoki Mizoshiri; Kentaro Igarashi; Shinji Miwa; Akihiko Takeuchi; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Toshikazu Kubo

  JAPANESE JOURNAL OF CLINICAL ONCOLOGY OXFORD UNIV PRESS 46 (8) 735 - 740 0368-2811 2016/08 [Refereed]
  
• Prediction of skeletal-related events in patients with non-small cell lung cancer

  Hisaki Aiba; Tomoki Kimura; Takaya Yamagami; Nobuyuki Watanabe; Hironari Sakurai; Hiroaki Kimura; Shingo Shimozaki; Satoshi Yamada; Takanobu Otsuka

  Supportive Care in Cancer 24 (8) 3361 - 3367 0941-4355 2016/08
• Treatment of a Simple Bone Cyst Using a Cannulated Hydroxyapatite Pin

  Toshiharu Shirai; Hiroyuki Tsuchiya; Ryu Terauchi; Shinji Tsuchida; Naoki Mizoshiri; Kazuya Ikoma; Hiroyoshi Fujiwara; Shinji Miwa; Hiroaki Kimura; Akihiko Takeuchi; Katsuhiro Hayashi; Norio Yamamoto; Toshikazu Kubo

  MEDICINE LIPPINCOTT WILLIAMS & WILKINS 94 (25) e1027  0025-7974 2015/06 [Refereed]
  
• Real-Time Fluorescence Imaging of the DNA Damage Repair Response During Mitosis

  Shinji Miwa; Shuya Yano; Mako Yamamoto; Yasunori Matsumoto; Fuminari Uehara; Yukihiko Hiroshima; Makoto Toneri; Takashi Murakami; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Elena V. Efimova; Hiroyuki Tsuchiya; Robert M. Hoffman

  JOURNAL OF CELLULAR BIOCHEMISTRY WILEY-BLACKWELL 116 (4) 661 - 666 0730-2312 2015/04 [Refereed]
  
• Efficacy of triplet regimen antiemetic therapy for chemotherapy-induced nausea and vomiting (CINV) in bone and soft tissue sarcoma patients receiving highly emetogenic chemotherapy, and an efficacy comparison of single-shot palonosetron and consecutive-day granisetron for CINV in a randomized, single-blinded crossover study

  Hiroaki Kimura; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Yoshikazu Tanzawa; Akihiko Takeuchi; Kentaro Igarashi; Hiroyuki Inatani; Shingo Shimozaki; Takashi Kato; Yu Aoki; Takashi Higuchi; Hiroyuki Tsuchiya

  CANCER MEDICINE WILEY-BLACKWELL 4 (3) 333 - 341 2045-7634 2015/03 [Refereed]
  
• Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R.

  Shinji Miwa; Yong Zhang; Kyung-Eun Baek; Fuminari Uehara; Shuya Yano; Mako Yamamoto; Yukihiko Hiroshima; Yasunori Matsumoto; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Michael Bouvet; Hiroyuki Tsuchiya; Robert M Hoffman; Ming Zhao

  Oncotarget 5 (24) 12849 - 61 2014/12
• Fluorescence-guided surgery improves outcome in an orthotopic osteosarcoma nude-mouse model.

  Shinji Miwa; Yukihiko Hiroshima; Shuya Yano; Yong Zhang; Yasunori Matsumoto; Fuminari Uehara; Mako Yamamoto; Hiroaki Kimura; Katsuhiro Hayashi; Michael Bouvet; Hiroyuki Tsuchiya; Robert M Hoffman

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 32 (12) 1596 - 601 2014/12
• Fluorescence-guided surgery of prostate cancer bone metastasis.

  Shinji Miwa; Yasunori Matsumoto; Yukihiko Hiroshima; Shuya Yano; Fuminari Uehara; Mako Yamamoto; Yong Zhang; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Michael Bouvet; Naotoshi Sugimoto; Hiroyuki Tsuchiya; Robert M Hoffman

  The Journal of surgical research 192 (1) 124 - 33 2014/11
• Outcomes and Complications of Reconstruction Using Tumor-bearing Frozen Autografts in Patients with Metastatic Bone Tumors

  Shinji Miwa; Akihiko Takeuchi; Toshiharu Shirai; Norio Yamamoto; Katsuhiro Hayashi; Hideji Nishida; Hiroaki Kimura; Kentaro Igarashi; Hiroyuki Tsuchiya

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 34 (10) 5569 - 5577 0250-7005 2014/10 [Refereed]
  
• Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice.

  Shinji Miwa; Shuya Yano; Yong Zhang; Yasunori Matsumoto; Fuminari Uehara; Mako Yamamoto; Yukihiko Hiroshima; Hiroaki Kimura; Katsuhiro Hayashi; Norio Yamamoto; Michael Bouvet; Hiroyuki Tsuchiya; Robert M Hoffman; Ming Zhao

  Oncotarget 5 (16) 7119 - 25 2014/08
• Diagnosis and treatment of low-grade osteosarcoma: experience with nine cases

  Katsuhiro Hayashi; Hiroyuki Tsuchiya; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Inatani; Hideki Okamoto; Satoshi Yamada; Hiroko Ikeda; Seiko Sawada-Kitamura; Takayuki Nojima; Akishi Ooi; Takanobu Otsuka

  INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY SPRINGER JAPAN KK 19 (4) 731 - 738 1341-9625 2014/08 [Refereed]
  
• Synovial Sarcoma in Knee Joint, Mimicking Low-grade Sarcoma Confirmed by Molecular Detection of SYT Gene Split

  Hiroaki Kimura; Norio Yamamoto; Hider Nishida; Katsuhiro Hayashi; Akihiko Takeuchi; Takayuki Nojima; Hiroko Ikeda; Seiko Sawada-Kitamura; Hiroyuki Tsuchiya

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 34 (6) 3105 - 3111 0250-7005 2014/06 [Refereed]
  
• Late recurrence of osteosarcoma: a report of two cases

  Kentaro Igarashi; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Yoshikazu Tanzawa; Hiroaki Kimura; Akihiko Takeuchi; Shinji Miwa; Hiroyuki Inatani; Shingo Shimozaki; Takashi Kato; Hiroyuki Tsuchiya

  JOURNAL OF ORTHOPAEDIC SURGERY HONG KONG ACAD MEDICINE PRESS 22 (3) 415 - 419 1022-5536 2014 [Refereed]
  
• Pedicle versus free frozen autograft for reconstruction in malignant bone and soft tissue tumors of the lower extremities

  Shingo Shimozaki; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Yoshikazu Tanzawa; Hiroaki Kimura; Akihiko Takeuchi; Kentaro Igarashi; Hiroyuki Inatani; Takashi Kato; Hiroyuki Tsuchiya

  JOURNAL OF ORTHOPAEDIC SCIENCE SPRINGER JAPAN KK 19 (1) 156 - 163 0949-2658 2014/01 [Refereed]
  
• Dynamic Color-Coded Fluorescence Imaging of the Cell-Cycle Phase, Mitosis, and Apoptosis Demonstrates How Caffeine Modulates Cisplatinum Efficacy

  Shinji Miwa; Shuya Yano; Yasunori Tome; Naotoshi Sugimoto; Yukihiko Hiroshima; Fuminari Uehara; Sumiyuki Mii; Hiroaki Kimura; Katsuhiro Hayashi; Elena V. Efimova; Toshiyoshi Fujiwara; Hiroyuki Tsuchiya; Robert M. Hoffman

  JOURNAL OF CELLULAR BIOCHEMISTRY WILEY-BLACKWELL 114 (11) 2454 - 2460 0730-2312 2013/11 [Refereed]
  
• Huge and deeply situated glomus tumor: Its malignant form

  Toshiharu Shirai; Hiroyuki Tsuchiya; Norio Yamamoto; Katsuhiro Hayashi; Hideji Nishida; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Hiroko Ikeda

  Current Orthopaedic Practice 24 (6) 670 - 673 1940-7041 2013/11 [Refereed]
  
• High lung-metastatic variant of human osteosarcoma cells, selected by passage of lung metastasis in nude mice, is associated with increased expression of α(v)β(3) integrin.

  Yasunori Tome; Hiroaki Kimura; Hiroki Maehara; Naotoshi Sugimoto; Michael Bouvet; Hiroyuki Tsuchiya; Fuminori Kanaya; Robert M Hoffman

  Anticancer research 33 (9) 3623 - 7 2013/09
• Prognostic Value of Histological Response to Chemotherapy in Osteosarcoma Patients Receiving Tumor-Bearing Frozen Autograft

  Shinji Miwa; Akihiko Takeuchi; Hiroko Ikeda; Toshiharu Shirai; Norio Yamamoto; Hideji Nishida; Katsuhiro Hayashi; Yoshikazu Tanzawa; Hiroaki Kimura; Kentaro Igarashi; Hiroyuki Tsuchiya

  PLOS ONE PUBLIC LIBRARY SCIENCE 8 (8) e71362  1932-6203 2013/08 [Refereed]
  
• Prognostic Value of Radiological Response to Chemotherapy in Patients with Osteosarcoma

  Shinji Miwa; Akihiko Takeuchi; Toshiharu Shirai; Junichi Taki; Norio Yamamoto; Hideji Nishida; Katsuhiro Hayashi; Yoshikazu Tanzawa; Hiroaki Kimura; Kentaro Igarashi; Akishi Ooi; Hiroyuki Tsuchiya

  PLOS ONE PUBLIC LIBRARY SCIENCE 8 (7) e70015  1932-6203 2013/07 [Refereed]
  
• TNF-α and Tumor Lysate Promote the Maturation of Dendritic Cells for Immunotherapy for Advanced Malignant Bone and Soft Tissue Tumors

  Shinji Miwa; Hideji Nishida; Yoshikazu Tanzawa; Munetomo Takata; Akihiko Takeuchi; Norio Yamamoto; Toshiharu Shirai; Katsuhiro Hayashi; Hiroaki Kimura; Kentaro Igarashi; Eishiro Mizukoshi; Yasunari Nakamoto; Shuichi Kaneko; Hiroyuki Tsuchiya

  PLoS ONE Public Library of Science (PLoS) 7 (12) e52926 - e52926 2012/12
• Imaging the inhibition by anti-beta 1 integrin antibody of lung seeding of single osteosarcoma cells in live mice

  Hiroaki Kimura; Yasunori Tome; Masashi Momiyama; Katsuhiro Hayashi; Hiroyuki Tsuchiya; Michael Bouvet; Robert M. Hoffman

  INTERNATIONAL JOURNAL OF CANCER WILEY-BLACKWELL 131 (9) 2027 - 2033 0020-7136 2012/11 [Refereed]
  
• Caffeine Induces Apoptosis of Osteosarcoma Cells by Inhibiting AKT/mTOR/S6K, NF-kappa B and MAPK Pathways

  Shinji Miwa; Naotoshi Sugimoto; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Hiroaki Kimura; Akihiko Takeuchi; Kentaro Igarashi; Akihiro Yachie; Hiroyuki Tsuchiya

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 32 (9) 3643 - 3649 0250-7005 2012/09 [Refereed]
  
• Treatment Strategies for Well-differentiated Liposarcomas and Therapeutic Outcomes

  Norio Yamamoto; Katsuhiro Hayashi; Yoshikazu Tanzawa; Hiroaki Kimura; Akihiko Takeuchi; Kentaro Igarashi; Hiroyuki Inatani; Shingo Shimozaki; Seiko Kitamura; Hiroyuki Tsuchiya

  ANTICANCER RESEARCH INT INST ANTICANCER RESEARCH 32 (5) 1821 - 1825 0250-7005 2012/05 [Refereed]
  
• Activity of bone morphogenetic protein-7 after treatment at various temperatures: Freezing vs. pasteurization vs. allograft

  Munetomo Takata; Naotoshi Sugimoto; Norio Yamamoto; Toshiharu Shirai; Katsuhiro Hayashi; Hideji Nishida; Yoshikazu Tanzawa; Hiroaki Kimura; Shinji Miwa; Akihiko Takeuchi; Hiroyuki Tsuchiya

  CRYOBIOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE 63 (3) 235 - 239 0011-2240 2011/12 [Refereed]
  
• Functional outcomes after total scapulectomy for malignant bone or soft tissue tumors in the shoulder girdle

  Katsuhiro Hayashi; Mitsuaki Karita; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Akihiko Takeuchi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya

  INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY SPRINGER TOKYO 16 (5) 568 - 573 1341-9625 2011/10 [Refereed]
  
• UV Light Killing Efficacy of Fluorescent Protein-Expressing Cancer Cells In Vitro and In Vivo

  Hiroaki Kimura; Claudia Lee; Katsuhiro Hayashi; Kensuke Yamauchi; Norio Yamamoto; Hiroyuki Tsuchiya; Katsuro Tomita; Michael Bouvet; Robert M. Hoffman

  JOURNAL OF CELLULAR BIOCHEMISTRY WILEY-LISS 110 (6) 1439 - 1446 0730-2312 2010/08 [Refereed]
  
• Real-Time Imaging of Single Cancer-Cell Dynamics of Lung Metastasis

  Hiroaki Kimura; Katsuhiro Hayashi; Kensuke Yamauchi; Norio Yamamoto; Hiroyuki Tsuchiya; Katsuro Tomita; Hiroyuki Kishimoto; Michael Bouvet; Robert M. Hoffman

  JOURNAL OF CELLULAR BIOCHEMISTRY WILEY-LISS 109 (1) 58 - 64 0730-2312 2010/01 [Refereed]
  
• Caffeine-potentiated chemotherapy for metastatic osteosarcoma

  Hiroaki Kimura; Hiroyuki Tsuchiya; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Akihiko Takeuchi; Issei Ohnari; Katsuro Tomita

  JOURNAL OF ORTHOPAEDIC SCIENCE SPRINGER TOKYO 14 (5) 556 - 565 0949-2658 2009/09 [Refereed]
  
• Successful management of intractable infection after limb-saving surgery: A case report

  Hiroaki Kimura; Hiroyuki Tsuchiya; Toshiharu Shirai; Katsuhiro Hayashi; Hiroshi Hisakado; Akihiko Takeuchi; Katsuro Tomita

  Journal of Musculoskeletal Research 11 (4) 191 - 198 0218-9577 2008 [Refereed]
  

MISC

• 軟部肉腫に対するolaratumabの可能性 patient-derived orthotopic xenograft(PDOX)マウスモデルによる解析

  樋口 貴史; 山本 憲男; 林 克洋; 木村 浩明; 武内 章彦; 三輪 真嗣; 五十嵐 健太郎; 米澤 宏隆; 森永 整; 荒木 麗博; 土屋 弘行  日本整形外科学会雑誌  94-  (8)  S1985  -S1985  2020/09
• Impact of excision repair cross-complementation group 1 (ERCCI) protein on survival of patients with osteosarcoma treated with cisplatin-based chemotherapy.

  Kentaro Igarashi; Norio Yamamoto; Toshiharu Shirai; Katsuhiro Hayashi; Hideji Nishida; Hiroaki Kimura; Akihiko Takeuchi; Shinji Miwa; Hiroyuki Inatani; Shingo Shimozaki; Takashi Kato; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Use of thallium scintigraphy and bone scintigraphy for differentiating between chondrosarcoma and chondroblastic osteosarcoma

  Takashi Kato; Norio Yamamoto; Hideji Nishida; Hiroaki Kimura; Akihiko Takeuchi; Shingo Shimozaki; Yu Aoki; Takashi Higuchi; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Detection of MDM2 gene amplification in soft tissue sarcoma by FISH.

  Hiroaki Kimura; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Akihiko Takeuchi; Yoshikazu Tanzawa; Kentaro Igarashi; Shingo Shimozaki; Takashi Kato; Yu Aoki; Takashi Higuchi; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Prognostic value of peroxisome proliferator-activated receptor gamma expression on clinical outcome of myxoid liposarcoma.

  Akihiko Takeuchi; Norio Yamamoto; Toshiharu Shirai; Katsuhiro Hayashi; Hideji Nishida; Yoshikazu Tanzawa; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Shingo Shimozaki; Takashi Kato; Yu Aoki; Takashi Higuchi; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Minimally invasive surgery for simple bone cysts using hydroxyapatite cannulated pia: A long-term follow-up

  Takashi Higuchi; Norio Yamamoto; Hideji Nishida; Hiroaki Kimura; Akihiko Takeuchi; Shingo Shimozaki; Takashi Kato; Yu Aoki; Subhadrabandhu Saran; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Prognostic value of novel combined scoring system in patients with high-grade soft tissue sarcoma

  Akihiko Takeuchi; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Yoshikazu Tanzawa; Hiroaki Kimura; Shinji Miwa; Kentaro Igarashi; Shingo Shimozaki; Takashi Kato; Takashi Higuchi; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Pelvic reconstruction for malignant bone tumors using recycled frozen autograft

  Yu Aoki; Norio Yamamoto; Toshiharu Shirai; Hideji Nishida; Katsuhiro Hayashi; Yoshikazu Tanzawa; Hiroaki Kimura; Akihiko Takeuchi; Kentaro Igarashi; Hiroyuki Inatani; Shingo Shimozaki; Takashi Kato; Takashi Higuchi; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Long-term outcomes of tumor-bearing autografts treated with liquid nitrogen for reconstruction after tumor removal

  Norio Yamamoto; Kentaro Igarashi; Toshiharu Shirai; Katauhiro Hayashi; Hideji Nishida; Hiroaki Kimura; Akihiko Takeuchi; Shingo Shimozaki; Takeshi Kato; Yu Aoki; Takashi Higuchi; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Dendritic cells immunotherapy for patients with malignant bone and soft tissue tumors.

  Hideji Nishida; Norio Yamamoto; Akihiko Takeuchi; Hiroaki Kimura; Shingo Shimozaki; Takashi Kato; Yu Aoki; Kentaro Igarashi; Takashi Higuchi; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• Molecular targeted therapy for osteosarcoma using glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors.

  Shingo Shimozaki; Norio Yamamoto; Hideji Nishida; Hiroaki Kimura; Akihiko Takeuchi; Takashi Kato; Yu Aoki; Takashi Higuchi; Toshinari Minamoto; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  32-  (15)  2014/05
• 骨肉腫におけるERCC1、MDR1、GSTP1の発現と予後

  五十嵐 健太郎; 山本 憲男; 白井 寿治; 西田 英司; 林 克洋; 丹沢 義一; 木村 浩明; 武内 章彦; 下崎 真吾; 加藤 貴士; 土屋 弘行  日本整形外科学会雑誌  87-  (2)  S280  -S280  2013/03
• Marginal resection for osteosarcoma: Long-term outcomes

  Norio Yamamoto; Akihiko Takeuchi; Toshiharu Shirai; Katsuhiro Hayashi; Hiroaki Kimura; Kentaro Igarashi; Hiroyuki Tsuchiya  JOURNAL OF CLINICAL ONCOLOGY  30-  (15)  2012/05
• Efficacy of novel platinum complexes against osteosarcoma bone targeting platinum and proteasome inhibitory platinum

  Kentaro Igarashi; Norio Yamamoto; Toshiharu Shirai; Katsuhiro Hayashi; Hideji Nishida; Akihiko Takeuchi; Yoshikazu Tanzawa; Hiroaki Kimura; Shinji Miwa; Hiroyuki Inatani; Shingo Shimozaki; Akira Odani; Hiroyuki Tsuchiya  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE  30-  S6  -S6  2012
• Anti-beta 1 integrin antibody inhibits osteosarcoma lung seeding and metastasis

  Hiroaki Kimura; Yasunori Tome; John Grzesiak; Masashi Momiyama; Katsuhiro Hayashi; Michael Bouvet; Hiroyuki Tsuchiya; Robert M. Hoffman  CANCER RESEARCH  71-  2011/04
• 肺におけるcancer cell dynamicsのリアルタイムイメージング(Real time imaging of cancer cell dynamics on the lung in the live mouse)

  山内 健輔; 木村 浩明; 林 克洋; 山本 憲男; 土屋 弘行; 富田 勝郎; Hoffman Robert M  日本癌学会総会記事  67回-  181  -181  2008/09
• 腫瘍標的サルモネラ株を使用した、マウス骨肉腫の原発巣及び肺転移の治療(Targeted therapy of bone tumor and lung metastasis in mice with a tumor-selective strain of Salmonella typhymurium)

  林 克洋; 土屋 弘行; 山本 憲男; 白井 寿治; 山内 健輔; 木村 浩明; 武内 章彦; ジョ・ミン; ブベイ・マイケル; ホフマン・ロバート M; 富田 勝郎  日本癌学会総会記事  67回-  316  -317  2008/09

Research Grants & Projects

• Biological reaction in rat model with space making radiation therapy system for pediatric tumor

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2021/04 -2024/03 

  Author : 亀井 美智; 岩田 宏満; 武田 理沙; 木村 浩明; 高木 大輔; 相羽 久輝

   

  本研究は、小児がん治療における陽子線照射時に安全に吸収性スペーサーを用いるため、ラットモデルを構築し、化学療法併用時の生体への影響について検証することを目的としている。 2021年度までに我々は、ラットモデルの構築のためのパイロット研究を終了し、研究方法を確立した。また既に本試験を開始している。 パイロット研究では、①ラットモデルに適切なスペーサーの大きさと手術手技の確立、②エンドキサン経口投与による化学療法のプロトコル確立、③安全性評価のための、血液毒性、炎症反応、病理組織による微小環境変化評価、CT撮像の画像解析の時期と項目の妥当性を検証した。成熟前のラットでは挿入可能なスペーサーの大きさが小さくなるため、吸収速度が速くなり評価が困難であった。さらにスペーサー留置部位、癒着防止シートの有無、大きさ、固定方法の検討を試みてプロトコルを確立した。実際には、成熟雄ラットを用い、留置術当日からエンドキサン投与を行い安全に解析が可能となっている。血液毒性については、エンドキサン投与の3－4日後に骨髄抑制が最も著明な傾向があり、28日以降は大きな変化が認められなかった。血液毒性、炎症反応の評価スケジュールを投与後3日後、1週間後、その後は1週間ごとに28日サイクルでの化学療法を実施することとした。Albの変化はラットモデルでは変化が認められず、中止とした。CT撮像については、撮像時期とともに、撮像スライス間隔、解像度の検討を行った。CT評価スケジュールは28日間隔とし、スペーサー断面の評価と減少率の解析が可能であった。 今後は、病理組織による微小環境の評価と合わせてスペーサー吸収形態の評価、二酸化炭素の産生、最終の吸収時期についても確認していく。
• Fluorescence imaging for investigation and treatment of bone and soft tissue tumors

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2014/04 -2017/03 

  Author : Tsuchiya Hiroyuki

   

  We demonstrate in vivo fluorescence imaging of bone-marrow micrometastasis of prostate cancer at the cellular level in nude mice using PC-3 human prostate cancer cells labeled with green fluorescent protein (GFP). PC-3-GFP cells were visualized by real-time fluorescence imaging, to traffic and grow in the bone marrow. Formation of bone marrow micrometastasis could be imaged at the single-cell level in live mice, using confocal microscopy. We investigated the efficacies of fluorescence-guided surgery (FGS), genetically-modified auxotrophic strain of Salmonella typhimurium (A1-R), and glycogen synthase kinase-3β (GSK- 3β) inhibitors. FGS significantly reduced residual tumor as well as the recurrence of experimental prostate-cancer bone metastasis. A1-R significantly inhibited tumor growth and metastasis in soft tissue tumor model and bone metastasis model. Treatment with GSK-3β inhibitors attenuated the growth of orthotopic osteosarcoma in mice.
• Correlation between cell cycle and chemotherapy resistance and lung metastases - Analysis using Fucci transfected sarcoma cells

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2013/04 -2016/03 

  Author : KIMRA HIROAKI

   

  we utilized the fluorescence ubiquitination-based cell cycle indicator (FUCCI) imaging system to investigate the correlation between cell-cycle behavior and apoptosis after treatment of osteosarcoma cells with chemotherapeutic drugs. Osteosarcoma cell line 143B expressing FUCCI were treated with doxorubicin or cisplatinum, and we revealed that apoptosis behavior, cell cycle arrest, and chemotherapy sensitivity depending on cell cycle differs in each chemotherapy drugs.
• Relationship between lung metastases of osteosarcoma and coagulation-fibrinolytic factors

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011 -2012 

  Author : KIMURA Hiroaki

   

  With use of human osteosarcoma cell line “143B dual color”, in which GFP is expressing in nucleus and RFP is expressing in cytoplasm, we first developed multiple cell lines that have multiple metastatic potential. In each cell line, we evaluated expression level of uPA, PAI-1, and TF by ELIZA and PCR. The result showed strong relationship between metastatic potential and expression of uPA & PAI-1. We have now performed shRNA of uAP & PAI-1 for 143B cell line. Then we will evaluate how metastatic potential change after suppression of uPA and PAI-1 in osteosarcoma.

Other link

researchmap

https://researchmap.jp/hikimura