Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2019/04 -2022/03
Author : Kusama Nobuyoshi
The study examined the effects of the chronic presence of pain on brain activity. By a unique system that simultaneously makes electrophysiological recordings from multiple brain regions, recordings were made from a wide range of brain regions in rats with neuropathic pain. Simultaneous recording of somatosensory and emotional brain activity in unanesthetized, unrestrained (free-running) neuropathic pain model rats revealed changes in brain activity in multiple brain regions. In particular, periodic brain activity in the gamma-band was enhanced in the nucleus accumbens and the prefrontal cortex. There was no correlation between the gamma-band brain activities in these two regions, and they occurred almost simultaneously.