MF Researcher Database

Researchers Database

Advance

MATOBA Takuma

    Graduate School of Medical Sciences Department of Otolaryngology, Head and Neck Surgery　Assistant Professor
Last Updated :2024/06/11

Researcher Information

Degree

  • Ph.D.（2019/03 Nagoya City University）

J-Global ID

Research Interests

  • Head and neck cancer, regulatory T cell   

Research Areas

  • Life sciences / Immunology / Treg, anti-tumor immunity
  • Life sciences / Otorhinolaryngology / Head and neck cancer, Head and neck surgery, Treg

Academic & Professional Experience

  • 2019/05 - Today  Nagoya City UniversityGraduate School of Medical Sciences Department of Otolaryngology, Head and Neck SurgeryResearch Associate

Published Papers

MISC

Research Grants & Projects

  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2026/03 
    Author : 的場 拓磨; 岩崎 真一; 川北 大介; 今井 優樹
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    Date (from‐to) : 2019/10 -2022/03 
    Author : 山崎 小百合; 今井 優樹; 的場 拓磨; 志馬 寛明; 浦木 隆太
     
    自己免疫疾患は超高齢化社会の日本と世界の先進国で増加している。現在の自己免疫疾患の治療法は、ステロイドや免疫抑制剤を使用し、全身の免疫を抑制してしまうため、重篤な感染や発がんなどのリスクがある。そのため、発症メカニズムに基づいた治療戦略の開発が急務である。この度、私たちは自己免疫疾患発症や増悪の要因として、病巣感染に着目した。病巣感染がどのようにして自己免疫疾患を誘因するか、その詳細な病態メカニズムは不明な点が多い。これまでの私たちの研究成果を発展させて、各専門分野の先端研究者である海外共同研究者と協力し、病巣感染の病態メカニズムに迫ることを目指す。将来、高齢者でも安心な合併症の少ない、発症メカニズムに基づいた治療法の開発への貢献を目指す。 2020年2月まで、名市大への海外共同研究者の招聘、訪問時や国際学会参加時における共同研究打ち合わせは順調にすすんだ。若手研究者を交えた活発な討論ができ、若手研究者にとっては貴重な体験となった。2020年3月に海外共同研究先への渡航、及び海外共同研究者の名市大への訪問も計画していたが、新型コロナウイルス感染拡大のため、ともに延期になった。新型コロナウイルス感染の収束後に海外共同研究先での実験をすみやかに行えるよう、共同研究打ち合わせを行いつつ、実験条件の設定などの予備実験を現在行い、順調に進んでいる。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2019/04 -2021/03 
    Author : Matoba Takuma
     
    Head and neck cancer is mainly located in oral cavity, pharynx or larynx. I conducted this study focused on anti-tumor immunity to contribute developing a new treatment of head and neck cancer. Anti-tumor immunity is the inherent ability to eliminate tumor such as cancer. I focused on regulatory T cells, that representative cells regulate anti-tumor immunity. In the result, I elucidated that regulatory T cells are proliferated in head and neck cancer and CTLA-4, an inhibitory molecule, is abundant on the cell surface. I found a part of the mechanism how regulatory T cells acquire such features in head and neck cancer.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2017/04 -2019/03 
    Author : Matoba Takuma; IMAI masaki; OHKURA naganari; KAWAKITA daisuke; IJICHI kei; TOYAMA tatsuya; MORITA akimichi; MURAKAMI shingo; SAKAGUCHI shimon; YAMAZAKI sayuri
     
    Regulatory T cells suppress several types of immunity, including anti-tumor immunity. On the other hand, head and neck cancer, mostly occurred from oral cavity, pharynx and larynx, have been increasing recently. To find out the feature of regulatory T cells in head and neck cancer, we analyzed the phenotypes and gene expression patterns of those cells. As a result, we found that the frequency of regulatory T cells was increased in head and neck cancer tissue and many of regulatory T cells expressed immune-suppressive molecules. Furthermore, we found the signature gene expression patterns of those regulatory T cells.

Other link

researchmap


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.