Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
Date (from‐to) : 2019/04 -2023/03
Author : Kamijima Michihiro
Obesity during childhood is an important public health issue because it can result in the development of type II diabetes, dyslipidemia, and hypertension later in the adulthood. In these years, a notion has been established that the environmental chemical exposure can contribute to the adipogenesis in the body and such chemicals are called as obesogen (OB). This study project aimed to clarify the exposure to OB candidates in small children in a birth cohort study, and to investigate the relationship between the exposure and the physique indices. The chemical exposure were assessed by measuring metabolites or their parent compounds excreted in the urine, and a method strategy was developed using model compounds to evaluate such exposure comprehensively. Gut microbiome in small children was also analyzed in this project from the viewpoint of its possible involvement in the toxicokinetics of OB.