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鄭 且均ジョン チャギュン

所属部署医学研究科病態生化学分野
職名准教授
メールアドレス
ホームページURLhttp://kaken.nii.ac.jp/ja/r/00464579
生年月日
Last Updated :2019/07/06

研究者基本情報

基本情報

    プロフィール:アルツハイマー病の原因遺伝子産物であるアミロイド前駆体タンパク質(APP)の輸送・代謝・機能を制御する機構を新たな視点から解明し、それを基盤にしたAβ産生調節法を開発することによって、アルツハイマー病(AD)の予防・治療法開発を目指します。

学位

  • 博士(医学)

経歴

  •   2010年, 独立行政法人国立長寿医療研究センター, その他

研究活動情報

研究分野

  • 神経科学, 神経科学一般

研究キーワード

    包括脳ネットワーク, 神経細胞死, APP代謝, アミロイドβ蛋白(Aβ), アルツハイマー病, amyloid β, ATBF1ノックアウトマウス

論文

  • Disorganization of Oligodendrocyte Development in the Layer II/III of the Sensorimotor Cortex Causes Motor Coordination Dysfunction in a Model of White Matter Injury in Neonatal Rats., Ueda Y, Misumi S, Suzuki M, Ogawa S, Nishigaki R, Ishida A, Jung CG, Hida H, Neurochemical research, 43, (1) 127 - 137,   2018年01月, 査読有り
  • A novel biosensor with high signal-to-noise ratio for real-time measurement of dopamine levels in vivo., Ishida A, Imamura A, Ueda Y, Shimizu T, Marumoto R, Jung CG, Hida H, Journal of neuroscience research,   2017年11月, 査読有り
  • A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression., Kawaguchi M, Hara N, Bilim V, Koike H, Suzuki M, Kim TS, Gao N, Dong Y, Zhang S, Fujinawa Y, Yamamoto O, Ito H, Tomita Y, Naruse Y, Sakamaki A, Ishii Y, Tsuneyama K, Inoue M, Itoh J, Yasuda M, Sakata N, Jung CG, Kanazawa S, Akatsu H, Minato H, Nojima T, Asai K, Miura Y, BMC cancer, 16, (1) ,   2016年10月, 査読有り
  • Tooth loss might not alter molecular pathogenesis in an aged transgenic Alzheimer's disease model mouse., Oue H, Miyamoto Y, Koretake K, Okada S, Doi K, Jung CG, Michikawa M, Akagawa Y, Gerodontology, 33, (3) 308 - 314,   2016年09月, 査読有り
  • Dysfunction in Motor Coordination in Neonatal White Matter Injury Model Without Apparent Neuron Loss., Misumi S, Ueda Y, Nishigaki R, Suzuki M, Ishida A, Jung CG, Hida H, Cell transplantation, 25, (7) 1381 - 1393,   2016年, 査読有り
  • Arachidonic acid diet attenuates brain Aβ deposition in Tg2576 mice., Hosono T, Nishitsuji K, Nakamura T, Jung CG, Kontani M, Tokuda H, Kawashima H, Kiso Y, Suzuki T, Michikawa M, Brain research, 1613, 92 - 99,   2015年07月, 査読有り
  • Early constraint-induced movement therapy promotes functional recovery and neuronal plasticity in a subcortical hemorrhage model rat., Ishida A, Misumi S, Ueda Y, Shimizu Y, Cha-Gyun J, Tamakoshi K, Ishida K, Hida H, Behavioural brain research, 284, 158 - 166,   2015年05月, 査読有り
  • Arachidonic or Docosahexaenoic Acid Diet Prevents Memory Impairment in Tg2576 Mice., Hosono T, Mouri A, Nishitsuji K, Jung CG, Kontani M, Tokuda H, Kawashima H, Shibata H, Suzuki T, Nabehsima T, Michikawa M, Journal of Alzheimer's disease : JAD, 48, (1) 149 - 162,   2015年, 査読有り
  • Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease., Jin JK, Jang B, Jin HT, Choi EK, Jung CG, Akatsu H, Kim JI, Carp RI, Kim YS, PloS one, 10, (4) ,   2015年, 査読有り
  • Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase., Jung CG, Uhm KO, Horike H, Kim MJ, Misumi S, Ishida A, Ueda Y, Choi EK, Kim YS, Michikawa M, Hida H, Journal of Alzheimer's disease : JAD, 43, (4) 1215 - 1228,   2015年, 査読有り
  • ATBF1 is a novel amyloid-β protein precursor (AβPP) binding protein that affects AβPP expression., Uhm KO, Kim MJ, Kawaguchi M, Akatsu H, Miura Y, Misumi S, Hida H, Choi EK, Kim YS, Michikawa M, Jung CG, Journal of Alzheimer's disease : JAD, 43, (1) 243 - 257,   2015年, 査読有り
  • Enhanced electrical responsiveness in the cerebral cortex with oral melatonin administration after a small hemorrhage near the internal capsule in rats., Ueda Y, Masuda T, Ishida A, Misumi S, Shimizu Y, Jung CG, Hida H, Journal of neuroscience research, 92, (11) 1499 - 1508,   2014年11月, 査読有り
  • Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice., Oue H, Miyamoto Y, Okada S, Koretake K, Jung CG, Michikawa M, Akagawa Y, Behavioural brain research, 252, 318 - 325,   2013年09月, 査読有り
  • [Tg2576 mouse model]., Jung CG, Michikawa M, Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 8, 252 - 255,   2011年10月, 査読有り
  • Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons., Jung CG, Uhm KO, Miura Y, Hosono T, Horike H, Khanna KK, Kim MJ, Michikawa M, Molecular neurodegeneration, 6,   2011年07月, 査読有り
  • Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function., Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung CG, Komano H, Michikawa M, The Journal of biological chemistry, 285, (49) 38382 - 38388,   2010年12月, 査読有り
  • The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress., Kim TS, Kawaguchi M, Suzuki M, Jung CG, Asai K, Shibamoto Y, Lavin MF, Khanna KK, Miura Y, Disease models & mechanisms, 3, (11-12) 752 - 762,   2010年11月, 査読有り
  • Treadmill running improves motor function and alters dendritic morphology in the striatum after collagenase-induced intracerebral hemorrhage in rats., Takamatsu Y, Ishida A, Hamakawa M, Tamakoshi K, Jung CG, Ishida K, Brain research, 1355, 165 - 173,   2010年10月, 査読有り
  • Honokiol increases ABCA1 expression level by activating retinoid X receptor beta., Jung CG, Horike H, Cha BY, Uhm KO, Yamauchi R, Yamaguchi T, Hosono T, Iida K, Woo JT, Michikawa M, Biological & pharmaceutical bulletin, 33, (7) 1105 - 1111,   2010年, 査読有り
  • Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy., Kim HJ, Jung CG, Dukala D, Bae H, Kakazu R, Wollmann R, Soliven B, Journal of neuroimmunology, 214, (1-2) 93 - 100,   2009年09月, 査読有り
  • Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture., Minagawa H, Gong JS, Jung CG, Watanabe A, Lund-Katz S, Phillips MC, Saito H, Michikawa M, Journal of neuroscience research, 87, (11) 2498 - 2508,   2009年08月, 査読有り
  • Targeting of myelin protein zero in a spontaneous autoimmune polyneuropathy., Kim HJ, Jung CG, Jensen MA, Dukala D, Soliven B, Journal of immunology (Baltimore, Md. : 1950), 181, (12) 8753 - 8760,   2008年12月, 査読有り
  • Enhanced neurogenesis from neural progenitor cells with G1/S-phase cell cycle arrest is mediated by transforming growth factor beta1., Misumi S, Kim TS, Jung CG, Masuda T, Urakawa S, Isobe Y, Furuyama F, Nishino H, Hida H, The European journal of neuroscience, 28, (6) 1049 - 1059,   2008年09月, 査読有り
  • Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-1alpha., Kim TS, Misumi S, Jung CG, Masuda T, Isobe Y, Furuyama F, Nishino H, Hida H, Journal of neuroscience research, 86, (11) 2353 - 2362,   2008年08月, 査読有り
  • FTY720 modulates human oligodendrocyte progenitor process extension and survival., Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP, Annals of neurology, 63, (1) 61 - 71,   2008年01月, 査読有り
  • A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat., Asano A, Tsubomatsu K, Jung CG, Sasaki N, Agui T, Mammalian genome : official journal of the International Mammalian Genome Society, 18, (11) 779 - 786,   2007年11月, 査読有り
  • Treatment with deferoxamine increases neurons from neural stem/progenitor cells., Kim HJ, Hida H, Jung CG, Miura Y, Nishino H, Brain research, 1092, (1) 1 - 15,   2006年05月, 査読有り
  • Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation., Jung CG, Kim HJ, Kawaguchi M, Khanna KK, Hida H, Asai K, Nishino H, Miura Y, Development (Cambridge, England), 132, (23) 5137 - 5145,   2005年12月, 査読有り
  • Pleiotrophin mRNA is highly expressed in neural stem (progenitor) cells of mouse ventral mesencephalon and the product promotes production of dopaminergic neurons from embryonic stem cell-derived nestin-positive cells., Jung CG, Hida H, Nakahira K, Ikenaka K, Kim HJ, Nishino H, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18, (11) 1237 - 1239,   2004年08月, 査読有り
  • High titer retroviral gene transduction to neural progenitor cells for establishment of donor cells for neural transplantation to parkinsonian model rats., Kodama Y, Hida H, Jung CG, Baba H, Isono M, Kobayashi H, Nishino H, Neurologia medico-chirurgica, 44, (7) 344 - 51; discussion 352,   2004年07月, 査読有り
  • Pleiotrophin exhibits a trophic effect on survival of dopaminergic neurons in vitro., Hida H, Jung CG, Wu CZ, Kim HJ, Kodama Y, Masuda T, Nishino H, The European journal of neuroscience, 17, (10) 2127 - 2134,   2003年05月, 査読有り


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