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今泉 祐治イマイズミ ユウジ

所属部署学長・副学長等
職名特任教授
メールアドレスyimaizumphar.nagoya-cu.ac.jp
ホームページURL
生年月日
Last Updated :2019/03/23

研究者基本情報

基本情報

    プロフィール:1976年3月 東京大学 薬学部 卒業
    1978年3月 東京大学 薬学系大学院 修士課程 修了
    1978年4月 名古屋市立大学 薬学部 薬品作用学講座 助手
    1981年12月 薬学博士(東京大学)
    1982年12月 名古屋市立大学 薬学部 薬品作用学講座 助教授
    1985年6月 カルガリー大学 医学部 生理学講座 長期海外出張(~1987年6月)
    1992年3月 日本薬理学会学術奨励賞受賞「各種平滑筋細胞の興奮性の多様性とその機序について」
    1997年1月 名古屋市立大学 薬学部 薬物治療学講座 教授
    2000年4月 名古屋市立大学 薬学部 薬品作用学講座 教授(担当替え)
    2002年4月 名古屋市立大学 大学院薬学研究科 細子分子薬効解析学分野 教授(改組)
    2005年4月 名古屋市立大学 大学院薬学研究科長・薬学部長(~2007年3月)
    2014年4月 名古屋市立大学 理事(研究・国際担当)・副学長 現在に至る
    2018年3月 日本薬学会賞受賞「疾患治療標的および創薬標的としてのイオンチャネル分子機能解明」
    2018年4月 名古屋市立大学 大学院薬学研究科 特任教授 現在に至る

学歴

  •  - 1976年, 東京大学, 薬学部, 生命薬学

学位

  • 東京大学薬学系研究科生命薬学/博士(薬学)

所属学協会

  • 日本薬学会
  • 日本薬理会
  • 日本平滑筋学会
  • 日本生理学会
  • 日本神経科学会

経歴

  • 1978-1981 名古屋市立大学(薬学部)1981-1996 名古屋市立大学

研究活動情報

研究キーワード

    イオンチャネル, カルシウムシグナリング, バイオイメージング, 平滑筋, イオントランスポーター

論文

  • Hypoxic stress upregulates Kir2.1 expression by a pathway including hypoxic-inducible factor-1α and dynamin2 in brain capillary endothelial cells., Yamamura H, Suzuki Y, Yamamura H, Asai K, Giles W, Imaizumi Y, American journal of physiology. Cell physiology, 315, (2) C202 - C213,   2018年08月, 査読有り
  • Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle., Matsuki K, Kato D, Takemoto M, Suzuki Y, Yamamura H, Ohya S, Takeshima H, Imaizumi Y, American journal of physiology. Cell physiology, 315, (1) C1 - C9,   2018年07月, 査読有り
  • ATP increases [Ca2+ ]i and activates a Ca2+ -dependent Cl- current in rat ventricular fibroblasts., Hatano N, Ohya S, Imaizumi Y, Clark RB, Belke D, Giles WR, Experimental physiology, 103, (5) 666 - 682,   2018年05月, 査読有り
  • Local Ca2+ coupling between mitochondria and sarcoplasmic reticulum following depolarization in guinea pig urinary bladder smooth muscle cells., Yamamura H, Kawasaki K, Inagaki S, Suzuki Y, Imaizumi Y, American journal of physiology. Cell physiology, 314, (1) C88 - C98,   2018年01月, 査読有り
  • TMEM16A and TMEM16B channel proteins generate Ca2+-activated Cl- current and regulate melatonin secretion in rat pineal glands., Yamamura H, Nishimura K, Hagihara Y, Suzuki Y, Imaizumi Y, The Journal of biological chemistry, 293, (3) 995 - 1006,   2018年01月, 査読有り
  • Physiological and Pathological Functions of Cl- Channels in Chondrocytes., Yamamura H, Suzuki Y, Imaizumi Y, Biological & pharmaceutical bulletin, 41, (8) 1145 - 1151,   2018年, 査読有り
  • Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K+ channels., Sakamoto K, Suzuki Y, Yamamura H, Ohya S, Muraki K, Imaizumi Y, Journal of pharmacological sciences, 133, (4) 223 - 231,   2017年04月, 査読有り
  • Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy., Matsuki K, Takemoto M, Suzuki Y, Yamamura H, Ohya S, Takeshima H, Imaizumi Y, Pflugers Archiv : European journal of physiology, 469, (2) 313 - 326,   2017年02月, 査読有り
  • Physiological roles of mitochondria and mitofusins on Ca2+ signaling in smooth muscles., Yamamura H, Suzuki Y, Imaizumi Y, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 149, (6) 260 - 263,   2017年, 査読有り
  • Up-Regulation of the Voltage-Gated KV2.1 K+ Channel in the Renal Arterial Myocytes of Dahl Salt-Sensitive Hypertensive Rats., Ogiwara K, Ohya S, Suzuki Y, Yamamura H, Imaizumi Y, Biological & pharmaceutical bulletin, 40, (9) 1468 - 1474,   2017年, 査読有り
  • Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems., Suzuki Y, Tsutsumi K, Miyamoto T, Yamamura H, Imaizumi Y, PloS one, 12, (10) ,   2017年, 査読有り
  • A New Splice Variant of Large Conductance Ca2+-activated K+ (BK) Channel α Subunit Alters Human Chondrocyte Function., Suzuki Y, Ohya S, Yamamura H, Giles WR, Imaizumi Y, The Journal of biological chemistry, 291, (46) 24247 - 24260,   2016年11月, 査読有り
  • Hypoxic stress up-regulates Kir2.1 expression and facilitates cell proliferation in brain capillary endothelial cells., Yamamura H, Suzuki Y, Yamamura H, Asai K, Imaizumi Y, Biochemical and biophysical research communications, 476, (4) 386 - 392,   2016年08月, 査読有り
  • Modulation of Ca2+ oscillation and melatonin secretion by BKCa channel activity in rat pinealocytes., Mizutani H, Yamamura H, Muramatsu M, Hagihara Y, Suzuki Y, Imaizumi Y, American journal of physiology. Cell physiology, 310, (9) C740 - 7,   2016年05月, 査読有り
  • Protein-Coupled Fluorescent Probe To Visualize Potassium Ion Transition on Cellular Membranes., Hirata T, Terai T, Yamamura H, Shimonishi M, Komatsu T, Hanaoka K, Ueno T, Imaizumi Y, Nagano T, Urano Y, Analytical chemistry, 88, (5) 2693 - 2700,   2016年03月, 査読有り
  • The ClC-7 Chloride Channel Is Downregulated by Hypoosmotic Stress in Human Chondrocytes., Kurita T, Yamamura H, Suzuki Y, Giles WR, Imaizumi Y, Molecular pharmacology, 88, (1) 113 - 120,   2015年07月, 査読有り
  • Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines., Inayama M, Suzuki Y, Yamada S, Kurita T, Yamamura H, Ohya S, Giles WR, Imaizumi Y, Cell calcium, 57, (5-6) 337 - 347,   2015年05月, 査読有り
  • New light on ion channel imaging by total internal reflection fluorescence (TIRF) microscopy., Yamamura H, Suzuki Y, Imaizumi Y, Journal of pharmacological sciences, 128, (1) 1 - 7,   2015年05月, 査読有り
  • Regulation of store-operated Ca2+ entry activity by cell cycle dependent up-regulation of Orai2 in brain capillary endothelial cells., Kito H, Yamamura H, Suzuki Y, Yamamura H, Ohya S, Asai K, Imaizumi Y, Biochemical and biophysical research communications, 459, (3) 457 - 462,   2015年04月, 査読有り
  • Spontaneous and nicotine-induced Ca2+ oscillations mediated by Ca2+ influx in rat pinealocytes., Mizutani H, Yamamura H, Muramatsu M, Kiyota K, Nishimura K, Suzuki Y, Ohya S, Imaizumi Y, American journal of physiology. Cell physiology, 306, (11) C1008 - 16,   2014年06月, 査読有り
  • MWCNT causes extensive damage to the ciliated epithelium of the trachea of rodents., Ohba T, Xu J, Alexander DB, Yamada A, Kanno J, Hirose A, Tsuda H, Imaizumi Y, The Journal of toxicological sciences, 39, (3) 499 - 505,   2014年06月, 査読有り
  • Upregulation of KCa3.1 K(+) channel in mesenteric lymph node CD4(+) T lymphocytes from a mouse model of dextran sodium sulfate-induced inflammatory bowel disease., Ohya S, Fukuyo Y, Kito H, Shibaoka R, Matsui M, Niguma H, Maeda Y, Yamamura H, Fujii M, Kimura K, Imaizumi Y, American journal of physiology. Gastrointestinal and liver physiology, 306, (10) G873 - 85,   2014年05月, 査読有り
  • The multiple expression of Ca²⁺-activated Cl⁻ channels via homo- and hetero-dimer formation of TMEM16A splicing variants in murine portal vein., Ohshiro J, Yamamura H, Saeki T, Suzuki Y, Imaizumi Y, Biochemical and biophysical research communications, 443, (2) 518 - 523,   2014年01月, 査読有り
  • Modulation of TMEM16A-channel activity as Ca²⁺ activated Cl⁻ conductance via the interaction with actin cytoskeleton in murine portal vein., Ohshiro J, Yamamura H, Suzuki Y, Imaizumi Y, Journal of pharmacological sciences, 125, (1) 107 - 111,   2014年, 査読有り
  • Membrane hyperpolarization induced by endoplasmic reticulum stress facilitates ca(2+) influx to regulate cell cycle progression in brain capillary endothelial cells., Kito H, Yamamura H, Suzuki Y, Ohya S, Asai K, Imaizumi Y, Journal of pharmacological sciences, 125, (2) 227 - 232,   2014年, 査読有り
  • Caveolin-1 facilitates the direct coupling between large conductance Ca2+-activated K+ (BKCa) and Cav1.2 Ca2+ channels and their clustering to regulate membrane excitability in vascular myocytes., Suzuki Y, Yamamura H, Ohya S, Imaizumi Y, The Journal of biological chemistry, 288, (51) 36750 - 36761,   2013年12月, 査読有り
  • Enhancement of Ca(2+) influx and ciliary beating by membrane hyperpolarization due to ATP-sensitive K(+) channel opening in mouse airway epithelial cells., Ohba T, Sawada E, Suzuki Y, Yamamura H, Ohya S, Tsuda H, Imaizumi Y, The Journal of pharmacology and experimental therapeutics, 347, (1) 145 - 153,   2013年10月, 査読有り
  • Overactive bladder mediated by accelerated Ca2+ influx mode of Na+/Ca2+ exchanger in smooth muscle., Yamamura H, Cole WC, Kita S, Hotta S, Murata H, Suzuki Y, Ohya S, Iwamoto T, Imaizumi Y, American journal of physiology. Cell physiology, 305, (3) C299 - 308,   2013年08月, 査読有り
  • Role of the K(Ca)3.1 K+ channel in auricular lymph node CD4+ T-lymphocyte function of the delayed-type hypersensitivity model., Ohya S, Nakamura E, Horiba S, Kito H, Matsui M, Yamamura H, Imaizumi Y, British journal of pharmacology, 169, (5) 1011 - 1023,   2013年07月, 査読有り
  • Facilitated hyperpolarization signaling in vascular smooth muscle-overexpressing TRIC-A channels., Tao S, Yamazaki D, Komazaki S, Zhao C, Iida T, Kakizawa S, Imaizumi Y, Takeshima H, The Journal of biological chemistry, 288, (22) 15581 - 15589,   2013年05月, 査読有り
  • Direct molecular interaction of caveolin-3 with KCa1.1 channel in living HEK293 cell expression system., Suzuki Y, Yamamura H, Ohya S, Imaizumi Y, Biochemical and biophysical research communications, 430, (3) 1169 - 1174,   2013年01月, 査読有り
  • New screening system for selective blockers of voltage-gated K(+) channels using recombinant cell lines dying upon single action potential., Fujii M, Hayashi K, Ohya S, Yamamura H, Imaizumi Y, Journal of pharmacological sciences, 123, (2) 147 - 158,   2013年, 査読有り
  • Total internal reflection fluorescence imaging of Ca(2+)-induced Ca(2+) release in mouse urinary bladder smooth muscle cells., Yamamura H, Imaizumi Y, Biochemical and biophysical research communications, 427, (1) 54 - 59,   2012年10月, 査読有り
  • Involvement of inositol 1,4,5-trisphosphate formation in the voltage-dependent regulation of the Ca(2+) concentration in porcine coronary arterial smooth muscle cells., Yamamura H, Ohya S, Muraki K, Imaizumi Y, The Journal of pharmacology and experimental therapeutics, 342, (2) 486 - 496,   2012年08月, 査読有り
  • Development of recombinant cell line co-expressing mutated Nav1.5, Kir2.1, and hERG for the safety assay of drug candidates., Fujii M, Ohya S, Yamamura H, Imaizumi Y, Journal of biomolecular screening, 17, (6) 773 - 784,   2012年07月, 査読有り
  • Molecular assembly and dynamics of fluorescent protein-tagged single KCa1.1 channel in expression system and vascular smooth muscle cells., Yamamura H, Ikeda C, Suzuki Y, Ohya S, Imaizumi Y, American journal of physiology. Cell physiology, 302, (8) C1257 - 68,   2012年04月, 査読有り
  • Down-regulation of the large-conductance Ca(2+)-activated K+ channel, K(Ca)1.1 in the prostatic stromal cells of benign prostate hyperplasia., Niwa S, Ohya S, Kojima Y, Sasaki S, Yamamura H, Sakuragi M, Kohri K, Imaizumi Y, Biological & pharmaceutical bulletin, 35, (5) 737 - 744,   2012年, 査読有り
  • [Screening methods for ion-channels drug discovery and new ideas]., Fujii M, Ohya S, Yamamura H, Imaizumi Y, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 138, (6) 229 - 233,   2011年12月, 査読有り
  • [Study on ion channel transporters as a target for the drug discovery]., Imaizumi Y, Kaneko S, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 138, (6) ,   2011年12月, 査読有り
  • Intermediate-conductance Ca2+-activated K+ channel, KCa3.1, as a novel therapeutic target for benign prostatic hyperplasia., Ohya S, Niwa S, Kojima Y, Sasaki S, Sakuragi M, Kohri K, Imaizumi Y, The Journal of pharmacology and experimental therapeutics, 338, (2) 528 - 536,   2011年08月, 査読有り
  • TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance., Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Takeshima H, Cell metabolism, 14, (2) 231 - 241,   2011年08月, 査読有り
  • Up-regulation of K(ir)2.1 by ER stress facilitates cell death of brain capillary endothelial cells., Kito H, Yamazaki D, Ohya S, Yamamura H, Asai K, Imaizumi Y, Biochemical and biophysical research communications, 411, (2) 293 - 298,   2011年07月, 査読有り
  • Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells., Ohya S, Niwa S, Yanagi A, Fukuyo Y, Yamamura H, Imaizumi Y, The Journal of biological chemistry, 286, (19) 16940 - 16952,   2011年05月, 査読有り
  • Contribution of K(ir)2 potassium channels to ATP-induced cell death in brain capillary endothelial cells and reconstructed HEK293 cell model., Yamazaki D, Kito H, Yamamoto S, Ohya S, Yamamura H, Asai K, Imaizumi Y, American journal of physiology. Cell physiology, 300, (1) C75 - 86,   2011年01月, 査読有り
  • Serotonin augments gut pacemaker activity via 5-HT3 receptors., Liu HN, Ohya S, Nishizawa Y, Sawamura K, Iino S, Syed MM, Goto K, Imaizumi Y, Nakayama S, PloS one, 6, (9) ,   2011年, 査読有り
  • Accelerated Ca2+ entry by membrane hyperpolarization due to Ca2+-activated K+ channel activation in response to histamine in chondrocytes., Funabashi K, Ohya S, Yamamura H, Hatano N, Muraki K, Giles W, Imaizumi Y, American journal of physiology. Cell physiology, 298, (4) C786 - 97,   2010年04月, 査読有り
  • Cellular Ca2+ dynamics in urinary bladder smooth muscle from transgenic mice overexpressing Na+-Ca2+ exchanger., Murata H, Hotta S, Sawada E, Yamamura H, Ohya S, Kita S, Iwamoto T, Imaizumi Y, Journal of pharmacological sciences, 112, (3) 373 - 377,   2010年, 査読有り
  • Contribution of chloride channel conductance to the regulation of resting membrane potential in chondrocytes., Funabashi K, Fujii M, Yamamura H, Ohya S, Imaizumi Y, Journal of pharmacological sciences, 113, (1) 94 - 99,   2010年, 査読有り
  • Novel spliced variants of large-conductance Ca(2+)-activated K(+)-channel β2-subunit in human and rodent pancreas., Ohya S, Fujimori T, Kimura T, Yamamura H, Imaizumi Y, Journal of pharmacological sciences, 114, (2) 198 - 205,   2010年, 査読有り
  • Inhibition of Kv1.3 potassium current by phosphoinositides and stromal-derived factor-1alpha in Jurkat T cells., Matsushita Y, Ohya S, Suzuki Y, Itoda H, Kimura T, Yamamura H, Imaizumi Y, American journal of physiology. Cell physiology, 296, (5) C1079 - 85,   2009年05月, 査読有り
  • Regulation of ryanodine receptor-mediated Ca(2+) release in vas deferens smooth muscle cells., Ohno A, Ohya S, Yamamura H, Imaizumi Y, Journal of pharmacological sciences, 110, (1) 78 - 86,   2009年05月, 査読有り
  • Gender difference in BK channel expression in amygdala complex of rat brain., Ohno A, Ohya S, Yamamura H, Imaizumi Y, Biochemical and biophysical research communications, 378, (4) 867 - 871,   2009年01月, 査読有り
  • Malignancy grade-dependent expression of K+-channel subtypes in human prostate cancer., Ohya S, Kimura K, Niwa S, Ohno A, Kojima Y, Sasaki S, Kohri K, Imaizumi Y, Journal of pharmacological sciences, 109, (1) 148 - 151,   2009年01月, 査読有り
  • TRPV4-like non-selective cation currents in cultured aortic myocytes., Tanaka R, Muraki K, Ohya S, Yamamura H, Hatano N, Itoh Y, Imaizumi Y, Journal of pharmacological sciences, 108, (2) 179 - 189,   2008年10月, 査読有り
  • Molecular mechanisms for Kv1.3 potassium channel current inhibition by CD3/CD28 stimulation in Jurkat T cells., Matsushita Y, Ohya S, Itoda H, Kimura T, Suzuki Y, Yamamura H, Imaizumi Y, Biochemical and biophysical research communications, 374, (1) 152 - 157,   2008年09月, 査読有り
  • A novel opener of large-conductance Ca2+ -activated K+ (BK) channel reduces ischemic injury in rat cardiac myocytes by activating mitochondrial K(Ca) channel., Sakamoto K, Ohya S, Muraki K, Imaizumi Y, Journal of pharmacological sciences, 108, (1) 135 - 139,   2008年09月, 査読有り
  • Electrophysiological properties of a novel Ca(2+)-activated K(+) channel expressed in human osteoblasts., Hirukawa K, Muraki K, Ohya S, Imaizumi Y, Togari A, Calcified tissue international, 83, (3) 222 - 229,   2008年09月, 査読有り
  • Cell-culture-dependent change of Ca2+ response of rat aortic myocytes to sphingosine-1-phosphate., Tanaka R, Muraki K, Ohya S, Itoh Y, Hatano N, Imaizumi Y, Journal of pharmacological sciences, 107, (4) 434 - 442,   2008年08月, 査読有り
  • Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle., Hotta S, Morimura K, Ohya S, Muraki K, Takeshima H, Imaizumi Y, The Journal of physiology, 582, (Pt 2) 489 - 506,   2007年07月, 査読有り
  • Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat T-lymphocyte., Morimoto T, Ohya S, Hayashi H, Onozaki K, Imaizumi Y, Journal of pharmacological sciences, 104, (1) 94 - 98,   2007年05月, 査読有り
  • Characteristics of the ATP-induced Ca2+-entry pathway in the t-BBEC 117 cell line derived from bovine brain endothelial cells., Yamazaki D, Ohya S, Asai K, Imaizumi Y, Journal of pharmacological sciences, 104, (1) 103 - 107,   2007年05月, 査読有り
  • Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits., Morimoto T, Sakamoto K, Sade H, Ohya S, Muraki K, Imaizumi Y, Molecular pharmacology, 71, (4) 1075 - 1088,   2007年04月, 査読有り
  • Methyl-beta-cyclodextrin prevents Ca2+-induced Ca2+ release in smooth muscle cells of mouse urinary bladder., Hotta S, Yamamura H, Ohya S, Imaizumi Y, Journal of pharmacological sciences, 103, (1) 121 - 126,   2007年01月, 査読有り
  • A New Insight into the Function of TRPV2 in Circulatory Organs, Muraki K, Shigekawa M, Imaizumi Y, Liedtke WB, Heller S,   2007年, 査読有り
  • Molecular and electrophysiological characteristics of K+ conductance sensitive to acidic pH in aortic smooth muscle cells of WKY and SHR., Kiyoshi H, Yamazaki D, Ohya S, Kitsukawa M, Muraki K, Saito SY, Ohizumi Y, Imaizumi Y, American journal of physiology. Heart and circulatory physiology, 291, (6) H2723 - 34,   2006年12月, 査読有り
  • Novel functions of small conductance Ca2+-activated K+ channel in enhanced cell proliferation by ATP in brain endothelial cells., Yamazaki D, Aoyama M, Ohya S, Muraki K, Asai K, Imaizumi Y, The Journal of biological chemistry, 281, (50) 38430 - 38439,   2006年12月, 査読有り
  • Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells., Morimura K, Yamamura H, Ohya S, Imaizumi Y, Journal of pharmacological sciences, 100, (3) 237 - 241,   2006年03月, 査読有り
  • Two-step Ca2+ intracellular release underlies excitation-contraction coupling in mouse urinary bladder myocytes., Morimura K, Ohi Y, Yamamura H, Ohya S, Muraki K, Imaizumi Y, American journal of physiology. Cell physiology, 290, (2) C388 - 403,   2006年02月, 査読有り
  • Activation of large-conductance, Ca2+-activated K+ channels by cannabinoids., Sade H, Muraki K, Ohya S, Hatano N, Imaizumi Y, American journal of physiology. Cell physiology, 290, (1) C77 - 86,   2006年01月, 査読有り
  • Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid., Sakamoto K, Nonomura T, Ohya S, Muraki K, Ohwada T, Imaizumi Y, The Journal of pharmacology and experimental therapeutics, 316, (1) 144 - 153,   2006年01月, 査読有り
  • Inherent pacemaker function of duodenal GIST., Furuzono S, Ohya S, Inoue S, Nakao A, Imaizumi Y, Nakayama S, European journal of cancer (Oxford, England : 1990), 42, (2) 243 - 248,   2006年01月, 査読有り
  • Cardioprotective effects of estradiol include the activation of large-conductance Ca(2+)-activated K(+) channels in cardiac mitochondria., Ohya S, Kuwata Y, Sakamoto K, Muraki K, Imaizumi Y, American journal of physiology. Heart and circulatory physiology, 289, (4) H1635 - 42,   2005年10月, 査読有り
  • Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility., Nakayama S, Ohya S, Liu HN, Watanabe T, Furuzono S, Wang J, Nishizawa Y, Aoyama M, Murase N, Matsubara T, Ito Y, Imaizumi Y, Kajioka S, Journal of cell science, 118, (Pt 18) 4163 - 4173,   2005年09月, 査読有り
  • Involvement of ryanodine receptors in pacemaker Ca2+ oscillation in murine gastric ICC., Liu HN, Ohya S, Wang J, Imaizumi Y, Nakayama S, Biochemical and biophysical research communications, 328, (2) 640 - 646,   2005年03月, 査読有り
  • Regulation of Kv4.3 currents by Ca2+/calmodulin-dependent protein kinase II., Sergeant GP, Ohya S, Reihill JA, Perrino BA, Amberg GC, Imaizumi Y, Horowitz B, Sanders KM, Koh SD, American journal of physiology. Cell physiology, 288, (2) C304 - 13,   2005年02月, 査読有り
  • Co-contribution of IP3R and Ca2+ influx pathways to pacemaker Ca2+ activity in stomach ICC., Liu HN, Ohya S, Furuzono S, Wang J, Imaizumi Y, Nakayama S, Journal of biological rhythms, 20, (1) 15 - 26,   2005年02月, 査読有り
  • Purinergic modulation of pacemaker Ca2+ activity in interstitial cells of Cajal., Furuzono S, Nakayama S, Imaizumi Y, Neuropharmacology, 48, (2) 264 - 273,   2005年02月, 査読有り
  • Requirement of ryanodine receptors for pacemaker Ca2+ activity in ICC and HEK293 cells., Aoyama M, Yamada A, Wang J, Ohya S, Furuzono S, Goto T, Hotta S, Ito Y, Matsubara T, Shimokata K, Chen SR, Imaizumi Y, Nakayama S, Journal of cell science, 117, (Pt 13) 2813 - 2825,   2004年06月, 査読有り
  • [Investigation into gastrointestinal pacemaker mechanism using cultured cell cluster preparation]., Nakayama S, Ohya S, Imaizumi Y, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 123, (3) 149 - 154,   2004年03月, 査読有り
  • Two arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current in the Kv4 channel subfamily., Hatano N, Ohya S, Muraki K, Clark RB, Giles WR, Imaizumi Y, The Journal of biological chemistry, 279, (7) 5450 - 5459,   2004年02月, 査読有り
  • KB-R7943 reveals possible involvement of Na(+)-Ca2+ exchanger in elevation of intracellular Ca2+ in rat carotid arterial myocytes., Takai N, Yamada A, Muraki K, Watanabe M, Imaizumi Y, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 40, (1) 35 - 42,   2004年02月, 査読有り
  • Dehydroabietic acid derivatives as a novel scaffold for large-conductance calcium-activated K+ channel openers., Ohwada T, Nonomura T, Maki K, Sakamoto K, Ohya S, Muraki K, Imaizumi Y, Bioorganic & medicinal chemistry letters, 13, (22) 3971 - 3974,   2003年11月, 査読有り
  • Effects of KRN4884, a novel K+ channel opener, on ionic currents in rabbit femoral arterial myocytes., Muraki K, Sasaoka A, Ohya S, Watanabe M, Imaizumi Y, Journal of pharmacological sciences, 93, (3) 289 - 298,   2003年11月, 査読有り
  • Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta3 subunit., Murakami M, Yamamura H, Suzuki T, Kang MG, Ohya S, Murakami A, Miyoshi I, Sasano H, Muraki K, Hano T, Kasai N, Nakayama S, Campbell KP, Flockerzi V, Imaizumi Y, Yanagisawa T, Iijima T, The Journal of biological chemistry, 278, (44) 43261 - 43267,   2003年10月, 査読有り
  • TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes., Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, Imaizumi Y, Circulation research, 93, (9) 829 - 838,   2003年10月, 査読有り
  • [Ionic mechanisms underlying the regulation of cell proliferation, differentiation and death]., Mori Y, Inagaki C, Kuno M, Inoue R, Okada Y, Imaizumi Y, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 122, (3) 201 - 214,   2003年09月, 査読有り
  • Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells., Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S, The Journal of neuroscience : the official journal of the Society for Neuroscience, 23, (19) 7376 - 7380,   2003年08月, 査読有り
  • A novel action of palmitoyl-L-carnitine in human vascular endothelial cells., Muraki K, Imaizumi Y, Journal of pharmacological sciences, 92, (3) 252 - 258,   2003年07月, 査読有り
  • Dihydropyridine Ca2+ channel antagonists and agonists block Kv4.2, Kv4.3 and Kv1.4 K+ channels expressed in HEK293 cells., Hatano N, Ohya S, Muraki K, Giles W, Imaizumi Y, British journal of pharmacology, 139, (3) 533 - 544,   2003年06月, 査読有り
  • A-type potassium currents in smooth muscle., Amberg GC, Koh SD, Imaizumi Y, Ohya S, Sanders KM, American journal of physiology. Cell physiology, 284, (3) C583 - 95,   2003年03月, 査読有り
  • Stoichiometry of Na+-Ca2+ exchange is 3:1 in guinea-pig ventricular myocytes., Hinata M, Yamamura H, Li L, Watanabe Y, Watano T, Imaizumi Y, Kimura J, The Journal of physiology, 545, (2) 453 - 461,   2002年12月, 査読有り
  • [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]., Muraki K, Itoh T, Imaizumi Y, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 120, (1) 101P - 103P,   2002年11月, 査読有り
  • Reexamination of the stoichiometry of Na+/Ca2+ exchange with whole-cell voltage clamp of guinea pig ventricular myocytes., Hinata M, Yamamura H, Li L, Watanabe Y, Watano T, Imaizumi Y, Kimura J, Annals of the New York Academy of Sciences, 976, 154 - 156,   2002年11月, 査読有り
  • Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit., Imaizumi Y, Sakamoto K, Yamada A, Hotta A, Ohya S, Muraki K, Uchiyama M, Ohwada T, Molecular pharmacology, 62, (4) 836 - 846,   2002年10月, 査読有り
  • Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes., Petrova R, Yamamoto Y, Muraki K, Yonekura H, Sakurai S, Watanabe T, Li H, Takeuchi M, Makita Z, Kato I, Takasawa S, Okamoto H, Imaizumi Y, Yamamoto H, Journal of molecular and cellular cardiology, 34, (10) 1425 - 1431,   2002年10月, 査読有り
  • Functional interaction between KChIP1 and GFP-fused Kv4.3L co-expressed in HEK293 cells., Hatano N, Ohya S, Imaizumi Y, Pflugers Archiv : European journal of physiology, 444, (1-2) 80 - 88,   2002年05月, 査読有り
  • Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid., Yamamura H, Sakamoto K, Ohya S, Muraki K, Imaizumi Y, Japanese journal of pharmacology, 89, (1) 53 - 63,   2002年05月, 査読有り
  • Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4., Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T, The Journal of biological chemistry, 277, (17) 14965 - 14975,   2002年04月, 査読有り
  • Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle., Ohya S, Asakura K, Muraki K, Watanabe M, Imaizumi Y, American journal of physiology. Gastrointestinal and liver physiology, 282, (2) G277 - 87,   2002年02月, 査読有り
  • 平滑筋機能からみた早産陣痛制御と治療薬の展望, 産婦人科の実際, 49/,903-913,   2000年
  • ハイスループット薬理学 : 創薬における研究手法の効率化と大規模化, 日本薬理学会誌, 118/,187-196,   2001年
  • Comparison of potassium currents in rabbit atrial and ventricular cells., 405/,123-145,   1988年
  • Properties of the transient outward current in rabbit atrial cells., 405/,147-168,   1988年
  • Parasympathetic denervation abolishes acetylcholine induced relaxation in the rat iris dilator., 156/,291-294,   1988年
  • Decrease in neuronal uptake of noradrenaline simply explains the supersensitivity after sympathectomy in the rat iris dilator., 50/,19-29,   1989年
  • Slow onset of and recovery from Ca, 51/,37-45,   1989年
  • Ionic currents in single smooth muscle cells from the ureter of the guinea pig., 441/,131-159,   1989年
  • Measurement and simulation of non-inactivating Ca current in smooth muscle cells., 256/,C880-C885,   1989年
  • Characteristics of transient outward current (I, 427/,301-324,   1990年
  • Atropine-resistant relaxation induced by high K, 100/,401-406,   1990年
  • Effects of tetraethylammonium and 4-aminophyridine on outward currents and excitability in canine tracheal smooth muscle cells., 100/,507-515,   1990年
  • Mechanisms of long-lasting effects of benidipine on Ca current in guinea pig ventricular cells., 100/,669-676,   1990年
  • Comparison of effects of cromakalim and pinacidil on mechanical activity and, 253/,586-563,   1990年
  • Possible involvement of ATP-sensitive K, 255/,818-825,   1990年
  • Mechanisms of norepinephrine-induced reduction of Ca, 260/,C17-C25,   1991年
  • Effects of norepinephrine and heparin on outward current in single smooth muscle of the guinea-pig vas deferens., 193/,375-378,   1991年
  • Inhibition of transient outward current by 1,4-dihydropyridine Ca-antagonists and agonist in cardiac myocytes isolated from the rabbit atrium., 260/,H1737-H1742,   1991年
  • Sodium currents in smooth muscle cells freshly isolated from stomach fundus of the rat and ureter of the guinea-pig., 442/,351-375,   1991年
  • Characteristics of [, 540/,331-334,   1991年
  • Single channel recording of Ca, 420/,461-469,   1992年
  • Effects of cyclopiazonic acid, a novel Ca, 106/,208-214,   1992年
  • Cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca, 107/,134-140,   1992年
  • Effects of ciliary ganglionectomy on contractile responses in dilator muscle of the rat iris., 56/,135-141,   1993年
  • Cyclopiazonic acid, an inhibitor of Ca, 110/,565-572,   1993年
  • Effect of isoprenaline on Ca, 471/,563-582,   1993年
  • Functional role of Ca, 265/,H843-H851,   1993年
  • Tetrahexylammonium ions increase Ca, 426/,363-370,   1994年
  • Receptor for catecholamines responding to catechol which potentiates voltage-dependent calcium current in single cells from guinea-peg taenia caeci., 111/,1154-1162,   1994年
  • Endothelium-dervied relaxing factor released by 5-HT : distinct from nitric oxide in basilar arteries of normotensive and hypertensive rats., 113/,324-330,   1994年
  • Effects of noradrenaline on membrane currents and action potential shape in smooth muscle cells from guinea-pig ureter., 481/,617-627,   1994年
  • Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle., 114/,769-776,   1995年
  • Pertsussis toxin-sensitive muscarinic relaxation in the rat irisdilator muscle., 114/,777-784,   1995年
  • Effects of sematilide, a novel class (], 68/,175-182,   1995年
  • Delayed rectifier K current in rabbit atrinl myocytes., 269/,H524-H532,   1995年
  • Characteristics of caffeine-induced and spontaneous inward currents and related intracellular Ca, 282/,219-228,   1995年
  • Modulation of calcium channel currents by arachidonic acid in single smooth muscle cells from vas deferens of the guinea-pig., 115/,1887-1893,   1995年
  • Increased function of voltage-dependent Ca, 275/,775-783,   1995年
  • Opening of Ca, 70/,281-284,   1996年
  • Possible mechanism of the potent vasoconstrictor actions of ryanodine of femoral arteries from spontaneously hypertensive rats., 118/,1019-1027,   1996年
  • Time-courses of Ca, 306/,227-236,   1996年
  • Effects of NON-1101, a novel β-antagonist, on action potential and membrane currents in cardiac muscle., 278/,555-563,   1996年
  • Novel block of Ca, 71/,51-60,   1996年
  • Effects of sematilide, a novel Class (], 71/,361-365,   1996年
  • Superfical sarcoplasmic reticulum calcium buffering of resting, voltage-dependent Ca2+ influx in rat femoral arterial smooth muscle., 279/,830-837,   1996年
  • Different calcium stores for activation of Ca, 271/,C781-791,   1996年
  • Inhibition by the critical role of serine-175., 319/,551-558,   1996年
  • Spontaneous transient outward currents in smooth muscle cells., 20/2,141-152,   1996年
  • Potent vasoconstrictor actions of cyclopiaxonic acid and thapsigargin on femoral arteries from spontaneously hypertensive rats., 120/,65-73,   1997年
  • Effects of arachidonic acid on A-type potassium currents in smooth muscle cells of the guinea-pig, 272/,C860-C869,   1997年
  • Molecular cloning of a novel gene involved in serotonin receptor-mediated signal transduction in rat stomach, 401/,252-258,   1997年
  • Effects of sematilide, a novel class (]G0003[) antiarrhythmic agent on membrane currents in rabbit atrial myocytes, 331/,295-302,   1997年
  • Apamin-sensitive Ca, 236/,340-343,   1997年
  • Molecular cloning and tissue distribution of an alternatively spliced variant of an A-type K, 420/,47-53,   1997年
  • Comparative study of effects of isoproterenol and vasoactive intestinal polypeptide on voltage-dependent Ca, 30/,115-119,   1998年
  • Effects of ruthenium red on membrane ionic currents in urinary bladder smooth muscle cells of the guinea-pig, 435/,645-653,   1998年
  • Ca, 510/,705-719,   1998年
  • Effects of UTP on membrane current and potential in rat aortic myocytes, 360/,239-247,   1998年
  • Molecular colning of m3 muscarinic acetylcholine receptor in rat iris., 34/,111-122,   1998年
  • Ca, 276/,C566-C575,   1999年
  • Ca, 80/,1-8,   1999年
  • Effects ofK, 80/,243-253,   1999年
  • Effects of lactate on intracellular pH and hypercontracture during simulated ischemia and reperfusion in cardiac ventricular myocytes of the guinea pig, 80/,343-350,   1999年
  • Mechanisms of the palmitoylcarnitine-induced response in vascular endothelial cells, 438/,463-469,   1999年
  • Activation of Ca, 291/,140-146,   1999年
  • Levcromakalim causes indirect endothelial hyperpolarization via a myo-endothelial pathway., 128/,1491-1496,   1999年
  • Effects of AF64A on the mRNA levels of muscarinic receptors subtypes in the rat iris sphincter., 35/,171-180,   1999年
  • Supersensitivity by AF64A, a novel inhibitor of neuronal choline-uptake, of the rat iris sphincter smooth muscle., 35/,157-169,   1999年
  • Cromakalim-induced membrane current in guinea-pig tracheal smooth muscle cells., 389/,51-58,   2000年
  • Protective effect of benidipine against the abnormal electrical activity in single ventricular myocytes of the guinea-pig under simulated ischemic conditions and reperfusion., 82/,199-209,   2000年
  • Inhibition of smooth-muscle myosin-light-chain phosphatase by Ruthenium Red., 349/,797-804,   2000年
  • Nifedipine and nisoldipine modulate membrane potential of vascular endothelium via a myo-endothelial pathway., 67/,3163-3170,   2000年
  • SK4 encodes intermediate Ca, 84/,97-100,   2000年
  • Molecular analyses of non-specific supersensitivity induced by AF64A in rat iris smooth muscles., 36/,47-56,   2000年
  • Diverse expression of delayed rectifier K, 36/,101-115,   2000年
  • Conserved smooth muscle contractility and blood pressure increase in response to high-salt diet in mice lacking the beta3 subunit of the voltage-dependent calcium channel., 36/Suppl 2,S69-S73,   2000年
  • Comparative study on molecular and functional expression of L-type Ca, 441/,611-620,   2001年
  • BK channel activation by NS-1619 is partially mediated by intracellular Ca, 132/,828-834,   2001年
  • Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes., 132/,1154-1160,   2001年
  • Regional expression of the splice variants of Kv4.3 in rat brain and effects of C-terminus deletion on expressed K, 68/,1703-1716,   2001年
  • Imaging of Ca, 85/,382-390,   2001年
  • Ca, 86/,106-113,   2001年
  • Molecular cloning and expression of the novel splice variants of K, 282/,96-102,   2001年
  • Local Ca, 534/,313-326,   2001年
  • Usefulness an limitation of DiBAC, 86/,342-350,   2001年
  • 血管平滑筋細胞イオンチャネルとリモデリング, イオンチャネル最前線update 別冊医学の歩み, ,/pp.290-295,   2005年
  • Requirement of ryanodine receptor for pacemaker Ca, J. Cell Sci., 171, /2813-25,   2004年
  • Molecular basis of pimaran compounds as novel activators of large conductance Ca2+ activated K+ channel α-subunit., Mol. Pharmacol., 62,/ 836-846,   2002年

書籍等出版物

  • 各種平滑節細胞の興奮性の多様性とその機序について, 日本薬理学会誌(日本薬理学会奨励賞受賞総説),   1993年
  • Ca拮抗薬の平滑節Ca電流に対する選択的抑制作用について,   1993年
  • 心血管以外の臓器に対するKチャネル開口薬の作用。, 治療学,   1996年
  • Kチャネルと薬。, ファルマシア(セミナー),   1997年
  • 血管平滑節カルシウムチャネルの機能制御とその役割。, 循環器科,   1998年
  • 「平滑節組織及び単離細胞からの電気現象誘導法」, 生物薬科学実験講座 臓器機能測定法(]G0003[)広川書店,   1992年
  • 「下剤と止瀉剤」, 病気とくすり 南山堂,   1994年
  • 「オータコイド・抗アレルギー薬」, 薬学必携シリーズ 薬理学、第8章 朝倉書店,   1997年
  • 「平滑節」, 薬学必携シリーズ 薬理学、第11章 朝倉書店,   1997年
  • A comparative study about voltage-dependent Ca currents in smooth muscle cells isolated from several tissues.,   1989年
  • Measurement of noninactivating calcium current in smooth muscle cells.,   1991年
  • Electrical properties of iris sphincter.,   1992年
  • Effects of 9-methyl-7-bromoeudistomin D(MBED), a powerful Ca,   1993年
  • Noradrenaline-induced Ca-channel current modulation in smooth muscles.,   1996年
  • Regulation of Ca-dependent K current and action potential shape by intracellular Ca storage sites in some types of smooth muscle cells.,   1996年

受賞

  •   1992年, 日本薬理学会学術奨励賞

競争的資金

  • トランスポートソームによるペースメーカー活動の発生・調節機構
  • 細胞内カルシウムによるイオンチャネル活性制御機構と関連疾患の治療薬探索,   2002年 - 2004年
  • 電位依存性一過性Kチャネルのアラキドン酸感受性と遺伝子解析,   1998年 - 1999年
  • ラット胃セロトニン受容体に関連した低分子量タンパクの遺伝子クロ-ニングと発現,   1994年 - 1995年
  • 新規メカニズム導入によるイオンチャネル作用薬の効率的探索法の開発,   2003年 - 2004年
  • 心血管系病態でのイオンチャネル発現変化とその機構,   1998年 - 1999年
  • 生細胞内オルガネラ膜上タンパク質の一分子可視化技術の開拓
  • 気道平滑筋細胞のカルシウム依存性クロライドチャネルと気道過敏症,   1996年 - 1997年
  • 新たな疾患治療を目指したカルシウム活性化カリウムチャネル作用薬の薬効解析と応用
  • 各種平滑筋細胞におけるCaチャネル活性調節機構の多様性とそのメカニズム,   1992年 - 1993年


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