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津田　洋幸ツダ　ヒロユキ

所属部署大学付特任教授等津田特任教授研究室
職名特任教授
メールアドレスhtsudaphar.nagoya-cu.ac.jp
ホームページURLhttp://www.med.nagoya-cu.ac.jp/moltox.dir/index.html
生年月日
Last Updated :2020/01/09

研究者基本情報

学歴

  • 名古屋市立大学, 医学部

学位

  • 名古屋市立大学医学部／博士（医学）

所属学協会

  • 日本トキシコロジー学会
  • 日本毒性病理学会
  • 日本病理学会
  • 日本癌学会
  • 日本疾患モデル学会
  • 日本フードファクター学会
  • 日本がん予防研究会
  • 化学生物総合管理学会
  • アメリカ毒性病理学会
  • アメリカ癌学会
  • 国際泌尿器病理学会
  • 日本癌予防学会
  • 日本ラクトフェリン学会
  • 国際ラクトフェリン学会
  • WHO 国際癌研究機構

研究活動情報

研究キーワード

    ナノマテリアル毒性, 発がん/がん予防, 遺伝子改変動物

論文

  • Inhibitory effects of 17β-estradiol and 4-n-octylphenol on 7,12-dimethylbenz [a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats. (共著), Carcinogenesis, 23/7,1209-1215,   2002年
  • Cancer Prevention by Nutural Compounds., 19(4):/4,245-263,   2004年
    DOI
  • Full Length and Dalta Lactoferrin Display Differential Cell Localization Dynamics, but do not Act as Tumor Markers or Significantly Affect the Expression of other Genes., 1/,57-64,   2005年
    DOI
  • High susceptibility of human c-Ha-ras protooncogene transgenic rats to carcinogenesis: A cancer-prone animal model., 96/6,309-316,   2005年
    DOI
  • Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas., 27/12,2497-2510,   2006年
    DOI
  • Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens.
  • Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats., Kohno Hiroyuki, Suzuki Rikako, Sugie Shigeyuki, Tsuda Hiroyuki, Tanaka Takuji, Cancer science, 95, (4) 300 - 5,   2004年
    DOI
  • Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs., Fukamachi Katsumi, Matsuoka Yoichiro, Ohno Hiroshi, Hamaguchi Tetsuya, Tsuda Hiroyuki, The Journal of biological chemistry, 277, (46) 43549 - 52,   2002年
    DOI
  • Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine., Fukushima Shoji, Wanibuchi Hideki, Morimura Keiichirou, Wei Min, Nakae Dai, Konishi Yoichi, Tsuda Hiroyuki, Uehara Nobuaki, Imaida Katsumi, Shirai Tomoyuki, Tatematsu Masae, Tsukamoto Tetsuya, Hirose Masao, Furukawa Fumio, Wakabayashi Keiji, Totsuka Yukari, Japanese journal of cancer research : Gann, 93, (10) 1076 - 82,   2002年
  • Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats., Kohno Hiroyuki, Tanaka Takuji, Kawabata Kunihiro, Hirose Yoshinobu, Sugie Shigeyuki, Tsuda Hiroyuki, Mori Hideki, International journal of cancer. Journal international du cancer, 101, (5) 461 - 8,   2002年
    DOI
  • Use of Wild Rodents for Environmental Monitoring - Comparison of Rats in Bangkok and Rural Areas of Thailand., Doungchawee Galayanee, Khoaprasert Yuvaluk, Kongtim Suraphol, Thamavit Witaya, Tajima Kazuo, Moore Malcolm A, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 3, (4) 367 - 368,   2002年
  • The Contribution of Asian Countries to the International Cancer Prevention Effort - Reflections from a Glance at the Literature., Tajima Kazuo, Moore Malcolm A, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 3, (1) 1 - 2,   2002年
  • Requirement for Asian Pacific Collaboration in Assessment of Nutritional Factors Impacting on Cancer Development., Tajima Kazuo, Tsuda Hiroyuki, Moore Malcolm A, Asian Pacific journal of cancer prevention : APJCP, 3, (2) 93 - 96,   2002年
  • Cancer Screening: A Review with Particular Attention to Areas for Future International Research Efforts., Tsuda Hiroyuki, Moore Malcolm A, Asian Pacific journal of cancer prevention : APJCP, 3, (2) 99 - 123,   2002年
  • Food and Play Preferences - Does Cancer Prevention Require Targeting the Child?, Moore Malcolm A, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 3, (4) 279 - 280,   2002年
  • Smoking-Related Research in the Asian-Pacific Countries., Moore Malcolm A, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 3, (4) 291 - 304,   2002年
  • Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work., Tsuda Hiroyuki, Fukushima Shoji, Wanibuchi Hideki, Morimura Keiichirou, Nakae Dai, Imaida Katsumi, Tatematsu Masae, Hirose Masao, Wakabayashi Keiji, Moore Malcolm A, Toxicologic pathology, 31, (1) 80 - 6
    DOI
  • A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue., Tanaka Takuji, Kohno Hiroyuki, Nomura Eisaku, Taniguchi Hisaji, Tsuno Takuo, Tsuda Hiroyuki, Oncology, 64, (2) 166 - 75,   2003年
  • Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline., Fukushima Shoji, Wanibuchi Hideki, Morimura Keiichirou, Wei Min, Nakae Dai, Konishi Yoichi, Tsuda Hiroyuki, Takasuka Nobuo, Imaida Katsumi, Shirai Tomoyuki, Tatematsu Masae, Tsukamoto Tetsuya, Hirose Masao, Furukawa Fumio, Cancer letters, 191, (1) 35 - 40,   2003年
    DOI
  • Targeting the workplace for cervical and mammary cancer screening?, Moore Malcolm A, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 4, (1) 1 - 2
  • Appropriate models and an understanding of carcinogenic mechanisms--requirements for hazard risk assessment., Fukushima Shoji, Moore Malcolm A, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 4, (1) 75 - 8
  • Cancer screening literature in the period 2000-2002: pointers to future research avenues., Moore Malcolm A, Kunimoto Takehiko, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 4, (1) 57 - 60
  • Carcinogenesis and its modification by environmental endocrine disruptors: in vivo experimental and epidemiological findings., Tsuda Hiroyuki, Naito Akihiro, Kim Chuel Kyu, Fukamachi Katsumi, Nomoto Hiroshi, Moore Malcolm A, Japanese journal of clinical oncology, 33, (6) 259 - 70,   2003年
    DOI
  • Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: possible application for screening of chemopreventive agents., Matsuoka Yoichiro, Fukamachi Katsumi, Hamaguchi Tetsuya, Toriyama-Baba Hiroyasu, Kawaguchi Hiroaki, Kusunoki Masato, Yoshida Hiroki, Tsuda Hiroyuki, Toxicologic pathology, 31, (6) 632 - 7
    DOI
  • Experimental investigation of opisthorchiasis-associated cholangiocarcinoma induction inthe Syrian hamster - pointers for control of the human disease., Chaimuangraj Suchart, Thamavit Witaya, Tsuda Hiroyuki, Moore Malcolm A, Asian Pacific journal of cancer prevention : APJCP, 4, (2) 87 - 93
  • Can risk assessment and chemoprevention research rely on surrogates for tumour yield?, Moore Malcolm A, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 4, (3) 167 - 8
  • Grand challenges in global health and the practical prevention program? Asian focus on cancer prevention in females of the developing world., Moore Malcolm A, Tajima Kazuo, Anh Pham Hoang, Aydemir Gulsun, Basu Partha Sarathi, Bhurgri Yasmin, Chen Kexin, Gajalakshmi Vendhan, Hirose Kaoru, Jarrahi Alireza Mosavi, Ngoan Le Tran, Qiao You Lin, Shin Hai Rim, Sriamporn Supannee, Srivatanakul Petcharin, Tokudome Shinkan, Yoo Keun Young, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 4, (2) 153 - 65
  • Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells., Goldberg Gary S, Alexander David B, Pellicena Patricia, Zhang Zhong-Yin, Tsuda Hiroyuki, Miller W Todd, The Journal of biological chemistry, 278, (47) 46533 - 40,   2003年
    DOI
  • Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats., Hokaiwado Naomi, Asamoto Makoto, Cho Young-Man, Tsuda Hiroyuki, Shirai Tomoyuki, Cancer science, 94, (12) 1042 - 5,   2003年
    DOI
  • Terminal endbuds and acini as the respective major targets for chemical and sporadic carcinogenesis in the mammaryglands of human c-Ha-ras protooncogene transgenic rats., Hamaguchi Tetsuya, Matsuoka Yoichiro, Kawaguchi Hiroaki, Fukamachi Katsumi, Takasuka Nobuo, Ueda Shinobu, Shimizu Kimiko, Ohki Misao, Kusunoki Masato, Sakakura Teruyo, Yoshida Hiroki, Tsuda Hiroyuki, Breast cancer research and treatment, 83, (1) 43 - 56,   2004年
    DOI
  • Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis., Iigo Masaaki, Shimamura Mariko, Matsuda Eiji, Fujita Ken-ichi, Nomoto Hiroshi, Satoh Jun, Kojima Syuji, Alexander David B, Moore Malcolm A, Tsuda Hiroyuki, Cytokine, 25, (1) 36 - 44,   2004年
    DOI
  • Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate., Park Cheol Beom, Fukamachi Katsumi, Takasuka Nobuo, Han Beom Seok, Kim Chuel Kyu, Hamaguchi Tetsuya, Fujita Ken-ichi, Ueda Shinobu, Tsuda Hiroyuki, Cancer science, 95, (3) 205 - 10,   2004年
    DOI
  • Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats., Naito Akihiro, Suzuki Akane, Ueda Shinobu, Nomoto Hiroshi, Toriyama-Baba Hiroyasu, Asamoto Makoto, Tsuda Hiroyuki, Cancer science, 95, (5) 399 - 403,   2004年
    DOI
  • Possible enhancing effects of atrazine and nonylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats., Fukamachi Katsumi, Han Beom Seok, Kim Chuel Kyu, Takasuka Nobuo, Matsuoka Yoichiro, Matsuda Eiji, Yamasaki Tomomi, Tsuda Hiroyuki, Cancer science, 95, (5) 404 - 10,   2004年
    DOI
  • Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity., Alexander David B, Ichikawa Hitoshi, Bechberger John F, Valiunas Virginijus, Ohki Misao, Naus Christian C G, Kunimoto Takehiko, Tsuda Hiroyuki, Miller W Todd, Goldberg Gary S, Cancer research, 64, (4) 1347 - 58,   2004年
    DOI
  • Bovine lactoferrin inhibits tumor-induced angiogenesis., Shimamura Mariko, Yamamoto Yukio, Ashino Hiromi, Oikawa Tsutomu, Hazato Tadahiko, Tsuda Hiroyuki, Iigo Masaaki, International journal of cancer. Journal international du cancer, 111, (1) 111 - 6,   2004年
    DOI
  • Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats., Fujita Ken-ichi, Matsuda Eiji, Sekine Kazunori, Iigo Masaaki, Tsuda Hiroyuki, Carcinogenesis, 25, (10) 1961 - 6,   2004年
    DOI
  • Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine., Nozaki Shinichi, Maeda Mitsuaki, Tsuda Hiroyuki, Sledge George W, Breast cancer research and treatment, 83, (3) 195 - 9,   2004年
    DOI
  • Isoliquiritigenin, aflavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development., Takahashi Tetsuyuki, Takasuka Nobuo, Iigo Masaaki, Baba Masaki, Nishino Hoyoku, Tsuda Hiroyuki, Okuyama Toru, Cancer science, 95, (5) 448 - 53,   2004年
    DOI
  • Cancer prevention by natural compounds., Tsuda Hiroyuki, Ohshima Yutaka, Nomoto Hiroshi, Fujita Ken-ichi, Matsuda Eiji, Iigo Masaaki, Takasuka Nobuo, Moore Malcolm A, Drug metabolism and pharmacokinetics, 19, (4) 245 - 63,   2004年
    DOI
  • Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat., Fujita Ken-ichi, Matsuda Eiji, Sekine Kazunori, Iigo Masaaki, Tsuda Hiroyuki, Cancer letters, 213, (1) 21 - 9,   2004年
    DOI
  • Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis., Nomoto Hiroshi, Iigo Masaaki, Hamada Hiroki, Kojima Shuji, Tsuda Hiroyuki, Nutrition and cancer, 49, (1) 81 - 8,   2004年
  • Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes., Goldberg Gary S, Kunimoto Takehiko, Alexander David B, Suenaga Kayoko, Ishidate Fumiyoshi, Miyamoto Kazuaki, Ushijima Toshikazu, Teng Christina T, Yokota Jun, Ohta Tsutomu, Tsuda Hiroyuki, Medicinal chemistry (Shāriqah (United Arab Emirates)), 1, (1) 57 - 64,   2005年
    DOI
  • Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver., Fukushima Shoji, Wanibuchi Hideki, Morimura Keiichirou, Nakae Dai, Tsuda Hiroyuki, Imaida Katsumi, Shirai Tomoyuki, Tatematsu Masae, Tsukamoto Tetsuya, Hirose Masao, Furukawa Fumio, Cancer letters, 222, (1) 11 - 5,   2005年
    DOI
  • High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model., Tsuda Hiroyuki, Fukamachi Katsumi, Ohshima Yutaka, Ueda Shinobu, Matsuoka Yoichiro, Hamaguchi Tetsuya, Ohnishi Takamasa, Takasuka Nobuo, Naito Akihiro, Cancer science, 96, (6) 309 - 16,   2005年
    DOI
  • Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats., Kohno Hiroyuki, Suzuki Rikako, Sugie Shigeyuki, Tsuda Hiroyuki, Tanaka Takuji, Clinical cancer research : an official journal of the American Association for Cancer Research, 11, (13) 4962 - 7,   2005年
    DOI
  • Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats., Morimura Keiichirou, Kang Jin Seok, Wei Min, Wanibuchi Hideki, Tsuda Hiroyuki, Fukushima Shoji, Toxicologic pathology, 33, (7) 764 - 7,   2005年
    DOI
  • An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies., Suzuki Rikako, Kohno Hiroyuki, Suzui Masumi, Yoshimi Naoki, Tsuda Hiroyuki, Wakabayashi Keiji, Tanaka Takuji, Carcinogenesis, 27, (3) 619 - 30,   2006年
    DOI
  • Prevention of carcinogenesis and cancer metastasis by bovine lactoferrin., Tsuda Hiroyuki, Fukamachi Katsumi, Xu Jiegou, Sekine Kazunori, Ohkubo Shigetoshi, Takasuka Nobuo, Iigo Masaaki, Proceedings of the Japan Academy. Series B, Physical and biological sciences, 82, (7) 208 - 15,   2006年
    DOI
  • Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas., Ueda Shinobu, Fukamachi Katsumi, Matsuoka Yoichiro, Takasuka Nobuo, Takeshita Fumitaka, Naito Akihiro, Iigo Masaaki, Alexander David B, Moore Malcolm A, Saito Izumu, Ochiya Takahiro, Tsuda Hiroyuki, Carcinogenesis, 27, (12) 2497 - 510,   2006年
    DOI
  • Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens., Ohnishi Takamasa, Fukamachi Katsumi, Ohshima Yutaka, Jiegou Xu, Ueda Shinobu, Iigo Masaaki, Takasuka Nobuo, Naito Akihiro, Fujita Ken-ichi, Matsuoka Yoichiro, Izumi Keisuke, Tsuda Hiroyuki, Toxicologic pathology, 35, (3) 436 - 43,   2007年
    DOI
  • Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats., Tsuda Hiroyuki, Iigo Masaaki, Takasuka Nobuo, Ueda Shinobu, Ohshima Yutaka, Fukamachi Katsumi, Shirai Tomoyuki, Hirano Sachiko, Matsuda Eiji, Wakabayashi Keiji, Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 45, (6) 1013 - 9,   2007年
    DOI
  • Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens., Naiki-Ito Aya, Asamoto Makoto, Hokaiwado Naomi, Takahashi Satoru, Yamashita Hiroko, Tsuda Hiroyuki, Ogawa Kumiko, Shirai Tomoyuki, Cancer research, 67, (23) 11353 - 8,   2007年
    DOI
  • Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention., Matsuoka Yoichiro, Hamaguchi Tetsuya, Fukamachi Katsumi, Yoshida Midori, Watanabe Gen, Taya Kazuyoshi, Tsuda Hiroyuki, Tsubura Airo, Medical molecular morphology, 40, (4) 185 - 90,   2007年
    DOI
  • Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis., Matsuoka Yoichiro, Fukamachi Katsumi, Uehara Norihisa, Tsuda Hiroyuki, Tsubura Airo, Cancer science, 99, (2) 309 - 15,   2008年
    DOI
  • Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic., Kurosawa Gene, Akahori Yasushi, Morita Miwa, Sumitomo Mariko, Sato Noriko, Muramatsu Chiho, Eguchi Keiko, Matsuda Kazuki, Takasaki Akihiko, Tanaka Miho, Iba Yoshitaka, Hamada-Tsutsumi Susumu, Ukai Yoshinori, Shiraishi Mamoru, Suzuki Kazuhiro, Kurosawa Maiko, Fujiyama Sally, Takahashi Nobuhiro, Kato Ryoichi, Mizoguchi Yoshikazu, Shamoto Mikihiro, Tsuda Hiroyuki, Sugiura Mototaka, Hattori Yoshinobu, Miyakawa Shuichi, Shiroki Ryoichi, Hoshinaga Kiyotaka, Hayashi Nobuhiro, Sugioka Atsushi, Kurosawa Yoshikazu, Proceedings of the National Academy of Sciences of the United States of America, 105, (20) 7287 - 92,   2008年
    DOI
  • Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat., Fukamachi Katsumi, Imada Takafumi, Ohshima Yutaka, Xu Jiegou, Tsuda Hiroyuki, Cancer science, 99, (9) 1841 - 6,   2008年
    DOI
  • Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats., Tamano Seiko, Sekine Kazunori, Takase Mitsunori, Yamauchi Koji, Iigo Masaaki, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 9, (2) 313 - 6
  • Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine., Iigo Masaaki, Alexander David B, Long Ne, Xu Jiegou, Fukamachi Katsumi, Futakuchi Mitsuru, Takase Mitsunori, Tsuda Hiroyuki, Biochimie, 91, (1) 86 - 101,   2009年
    DOI
  • Establishment of rat embryonic stem cells and making of chimera rats., Ueda Shinobu, Kawamata Masaki, Teratani Takumi, Shimizu Taku, Tamai Yoshitaka, Ogawa Hiromasa, Hayashi Katsuyuki, Tsuda Hiroyuki, Ochiya Takahiro, PloS one, 3, (7) ,   2008年
    DOI
  • Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma., Kitamura Yuka, Kurosawa Gene, Tanaka Miho, Sumitomo Mariko, Muramatsu Chiho, Eguchi Keiko, Akahori Yasushi, Iba Yoshitaka, Tsuda Hiroyuki, Sugiura Mototaka, Hattori Yoshinobu, Kurosawa Yoshikazu, Biochemical and biophysical research communications, 383, (4) 480 - 4,   2009年
    DOI
  • An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas., Fukamachi Katsumi, Tanaka Hajime, Hagiwara Yoshiaki, Ohara Hirotaka, Joh Takashi, Iigo Masaaki, Alexander David B, Xu Jiegou, Long Ne, Takigahira Misato, Yanagihara Kazuyoshi, Hino Okio, Saito Izumu, TsudaHiroyuki, Biochemical and biophysical research communications, 390, (3) 636 - 41,   2009年
    DOI
  • Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial., Kozu Takahiro, Iinuma Gen, Ohashi Yasuo, Saito Yutaka, Akasu Takayuki, Saito Daizo, Alexander David B, Iigo Masaaki, Kakizoe Tadao, Tsuda Hiroyuki, Cancer prevention research (Philadelphia, Pa.), 2, (11) 975 - 83,   2009年
    DOI
  • Toxicology of engineered nanomaterials - a review of carcinogenic potential., Tsuda Hiroyuki, Xu Jiegou, Sakai Yuta, Futakuchi Mitsuru, Fukamachi Katsumi, Asian Pacific journal of cancer prevention : APJCP, 10, (6) 975 - 80,   2009年
  • Construction of a multi-functional helper-dependent adenovirus based system for cancer gene therapy., Long Ne, Hardiville Stephan, Pierce Annick, Fukamachi Katsume, Futakuchi Mitsuru, Alexander David B, Shirai Tomoyuki, Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 10, (5) 939 - 60,   2009年
  • Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats., Tanaka Hajime, Fukamachi Katsumi, Futakuchi Mitsuru, Alexander David B, Long Ne, Tamamushi Shojiro, Minami Kohtaro, Seino Susumu, Ohara Hirotaka, Joh Takashi, Tsuda Hiroyuki, Cancer science, 101, (2) 341 - 6,   2010年
    DOI
  • Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)., Sakamoto Yoshimitsu, Dai Nakae, Hagiwara Yoshiaki, Satoh Kanako, Ohashi Norio, Fukamachi Katsumi, Tsuda Hiroyuki, Hirose Akihiko, Nishimura Tetsuji, Hino Okio, Ogata Akio, The Journal of toxicological sciences, 35, (2) 265 - 70,   2010年
    DOI
  • A medium-term, rapid rat bioassay model for the detection of carcinogenic potential of chemicals., Tsuda Hiroyuki, Futakuchi Mitsuru, Fukamachi Katsumi, Shirai Tomoyuki, Imaida Katsumi, Fukushima Shoji, Tatematsu Masae, Furukawa Fumio, Tamano Seiko, Ito Nobuyuki, Toxicologic pathology, 38, (1) 182 - 7,   2010年
    DOI
  • Involvement of macrophage inflammatory protein 1alpha (MIP1alpha) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying., Xu Jiegou, Futakuchi Mitsuru, Iigo Masaaki, Fukamachi Katsumi, Alexander David B, Shimizu Hideo, Sakai Yuto, Tamano Seiko, Furukawa Fumio, Uchino Tadashi, Tokunaga Hiroshi, Nishimura Tetsuji, Hirose Akihiko, Kanno Jun, Tsuda Hiroyuki, Carcinogenesis, 31, (5) 927 - 35,   2010年
    DOI
  • Risk assessment studies of nanomaterials in Japan and other countries., Tsuda Hiroyuki, Asian Pacific journal of cancer prevention : APJCP, 11, (1) 13 - 4,   2010年
  • Cancer prevention by bovine lactoferrin: from animal studies to human trial., Tsuda Hiroyuki, Kozu Takahiro, Iinuma Gen, Ohashi Yasuo, Saito Yutaka, Saito Daizo, Akasu Takayuki, Alexander David B, Futakuchi Mitsuru, Fukamachi Katsumi, Xu Jiegou, Kakizoe Tadao, Iigo Masaaki, Biometals : an international journal on the role of metal ions in biology,biochemistry, and medicine, 23, (3) 399 - 409,   2010年
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  • International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies., Bolon Brad, Barale-Thomas Erio, Bradley Alys, Ettlin Robert A, Franchi Carla A S, George Catherine, Giusti Anna Maria, Hall Robert, Jacobsen Matthew, Konishi Yoichi, Ledieu David, Morton Daniel, Park Jae-Hak, Scudamore Cheryl L, Tsuda Hiroyuki, Vijayasarathi S K, Wijnands Marcel V W, Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 63, (1-2) 187 - 95,   2011年
    DOI
  • Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip / WAF1)., Wei Min, Wanibuchi Hideki, Nakae Dai, Tsuda Hiroyuki, Takahashi Satoru, Hirose Masao, Totsuka Yukari, Tatematsu Masae, Fukushima Shoji, Cancer science, 102, (1) 88 - 94,   2011年
    DOI
  • Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats., Xu Jiegou, Sagawa Yoko, Futakuchi Mitsuru, Fukamachi Katsumi, Alexander David B, Furukawa Fumio, Ikarashi Yoshiaki, Uchino Tadashi, Nishimura Tetsuji, Morita Akimichi, Suzui Masumi, Tsuda Hiroyuki, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49, (6) 1298 - 302,   2011年
    DOI
  • Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice., Sagawa Yoko, Futakuchi Mitsuru, Xu Jiegou, Fukamachi Katsumi, Sakai Yuto, Ikarashi Yoshiaki, Nishimura Tetsuji, Suzui Masumi, Tsuda Hiroyuki, Morita Akimichi, The Journal of toxicological sciences, 37, (2) 317 - 27,   2012年
    DOI
  • Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice., Takagi Atsuya, Hirose Akihiko, Futakuchi Mitsuru, Tsuda Hiroyuki, Kanno Jun, Cancer science, 103, (8) 1440 - 4,   2012年
    DOI
  • Lactoferrin: an alternative view of its role in human biological fluids., Alexander David B, Iigo Masaaki, Yamauchi Koji,Suzui Masumi, Tsuda Hiroyuki, Biochemistry and cell biology = Biochimie et biologie cellulaire, 90, (3) 279 - 306,   2012年
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  • Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats., Xu Jiegou, Futakuchi Mitsuru, Shimizu Hideo, Alexander David B, Yanagihara Kazuyoshi, Fukamachi Katsumi, Suzui Masumi, Kanno Jun, Hirose Akihiko, Ogata Akio, Sakamoto Yoshimitsu, Nakae Dai, Omori Toyonori, Tsuda Hiroyuki, Cancer science, 103, (12) 2045 - 50,   2012年
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  • Circulating microRNAs in serum of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas., Yabushita Setsuko, Fukamachi Katsumi, Tanaka Hajime, Sumida Kayo, Deguchi Yoshihito, Sukata Tokuo, Kawamura Satoshi, Uwagawa Satoshi, Suzui Masumi, Tsuda Hiroyuki, Pancreas, 41, (7) 1013 - 8,   2012年
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  • Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas., Yabushita Setsuko, Fukamachi Katsumi, Tanaka Hajime, Fukuda Takako, Sumida Kayo, Deguchi Yoshihito, Mikata Kazuki, Nishioka Kazuhiko, Kawamura Satoshi, Uwagawa Satoshi, Suzui Masumi, Alexander David B, Tsuda Hiroyuki, Carcinogenesis, 34, (6) 1251 - 9,   2013年
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  • Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer., Yabushita Setsuko, Fukamachi Katsumi, Kikuchi Fumitake, Ozaki Masakazu, Miyata Kaori, Sukata Tokuo, Deguchi Yoshihito, Tanaka Hajime, Kakehashi Anna, Kawamura Satoshi, Uwagawa Satoshi, Wanibuchi Hideki, Suzui Masumi, Alexander David B, Tsuda Hiroyuki, Pancreas, 42, (6) 1034 - 9,   2013年
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  • Enhancement of Ca(2+) influx and ciliary beating by membrane hyperpolarization due to ATP-sensitive K(+) channel opening in mouse airway epithelial cells., Ohba Teruya, Sawada Eiji, Suzuki Yoshiaki, Yamamura Hisao, Ohya Susumu, Tsuda Hiroyuki, Imaizumi Yuji, The Journal of pharmacology and experimental therapeutics, 347, (1) 145 - 53,   2013年
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  • A novel reporter rat strain that expresses LacZ upon Cre-mediated recombination., Fukamachi Katsumi, Tanaka Hajime, Sakai Yuto, Alexander David B, Futakuchi Mitsuru, Tsuda Hiroyuki, Suzui Masumi, Genesis (New York, N.Y. : 2000), 51, (4) 268 - 74,   2013年
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  • Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles., Xu Jiegou, Futakuchi Mitsuru, Alexander David B, Fukamachi Katsumi, Numano Takamasa, Suzui Masumi, Shimizu Hideo, Omori Toyonori, Kanno Jun, Hirose Akihiko, Tsuda Hiroyuki, Archives of toxicology, 88, (1) 65 - 75,   2014年
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  • Comparative study of toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro., Numano Takamasa, Xu Jiegou, Futakuchi Mitsuru, Fukamachi Katsumi, Alexander David B, Furukawa Fumio, Kanno Jun, Hirose Akihiko, Tsuda Hiroyuki, Suzui Masumi, Asian Pacific journal of cancer prevention : APJCP, 15, (2) 929 - 35,   2014年
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  • MWCNT causes extensive damage to the ciliated epithelium of the trachea of rodents., Ohba Teruya, Xu Jiegou, Alexander David B, Yamada Akane, Kanno Jun, Hirose Akihiko, Tsuda Hiroyuki, Imaizumi Yuji, The Journal of toxicological sciences, 39, (3) 499 - 505,   2014年
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  • Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes., Xu Jiegou, Alexander David B, Futakuchi Mitsuru, Numano Takamasa, Fukamachi Katsumi, Suzui Masumi, Omori Toyonori, Kanno Jun, Hirose Akihiko, Tsuda Hiroyuki, Cancer science, 105, (7) 763 - 9,   2014年
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  • Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine., Iigo Masaaki, Alexander David B, Xu Jiegou, Futakuchi Mitsuru, Suzui Masumi, Kozu Takahiro, Akasu Takayuki, Saito Daizo, Kakizoe Tadao, Yamauchi Koji, Abe Fumiaki, Takase Mitsunori, Sekine Kazunori, Tsuda Hiroyuki, Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 27, (5) 1017 - 29,   2014年
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  • A novel transgenic mouse model carrying human Tribbles related protein 3 (TRB3) gene and its site specific phenotype., Sakai Yuto, Fukamachi Katsumi, Futakuchi Mitsuru, Miyoshi Ichiro, Tsuda Hiroyuki, Suzui Masumi, Hayashi Hidetoshi, Biological&pharmaceutical bulletin, 37, (6) 1068 - 74,   2014年
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  • Rat N-ERC/mesothelin as a marker for in vivo screening of drugs against pancreas cancer., Fukamachi Katsumi, Iigo Masaaki, Hagiwara Yoshiaki, Shibata Koji, Futakuchi Mitsuru, Alexander David B, Hino Okio, Suzui Masumi, Tsuda Hiroyuki, PloS one, 9, (10) ,   2014年
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  • Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study., Xu Jiegou, Alexander David B, Iigo Masaaki, Hamano Hirokazu, Takahashi Satoru, Yokoyama Takako, Kato Munehiro, Usami Ikuji, Tokuyama Takeshi, Tsutsumi Masahiro, Tamura Mouka, Oguri Tetsuya, Niimi Akio, Hayashi Yoshimitsu, Yokoyama Yoshifumi, Tonegawa Ken, Fukamachi Katsumi, Futakuchi Mitsuru, Sakai Yuto, Suzui Masumi, Kamijima Michihiro, Hisanaga Naomi, Omori Toyonori, Nakae Dai, Hirose Akihiko, Kanno Jun, Tsuda Hiroyuki, Cancer science, 106, (7) 825 - 32,   2015年
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  • 血清診断が可能なラット肺がんモデル, 深町 勝巳,大嶋 浩,二口 充,津田 洋幸,酒々井 眞澄, 日本毒性学会学術年会, 40,   2013年
  • 多層カーボンナノチューブのラット肺ばく露に伴う炎症プロファイルと遺伝子発現特性, 酒々井 眞澄,沼野 琢旬,深町 勝巳,二口 充,津田 洋幸, 日本毒性学会学術年会, 40,   2013年
  • ナノ材料の噴霧曝露後，長期間経過して発生するリスクの背景となる肺組織の検索, 二口 充,徐 結苟,深町 勝巳,津田 洋幸,酒々井 眞澄, 日本毒性学会学術年会, 40,   2013年
  • 多層カーボンチューブとアスベストの経気管肺内噴霧投与による胸膜中皮の増殖, 津田 洋幸,徐 結苟,酒々井 真澄,二口 充,深町 勝巳,菅野 純,広瀬 明彦, 日本毒性学会学術年会, 40,   2013年
  • キラル高速液体クロマトグラフィー/大気圧化学イオン化質量分析法によるグリシドール脂肪酸エステルの光学異性体分析, 吉岡 智史,西村 一彦,高村 岳樹,酒々井 眞澄,津田 洋幸,板橋 豊, 分析化学 = Japan analyst, 61, (9) 783 - 790,   2012年
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  • フラーレンの肺内噴霧による肺発がんプロモーション作用の検討, 深町 勝巳,徐結苟,二口 充,橋爪 直樹,井上 義之,高月 峰夫,津田 洋幸,酒々井 眞澄, 日本毒性学会学術年会, 39, O - 33,   2012年
  • アナターゼ型ナノサイズ二酸化チタニウムの肺組織および培養マクロファージへの影響-ルチル型との比較検討-, 沼野 琢旬,徐 結苟,二口 充,深町 勝巳,清水 秀夫,古川 文夫,酒々井 眞澄,津田 洋幸, 日本毒性学会学術年会, 39, O - 32,   2012年
  • ナノサイズカーボンブラックの肺内噴霧により誘発された肺胞過形成, 二口 充,徐 結苟,井上 義之,高月 峰夫,津田 洋幸,酒々井 真澄, 日本毒性学会学術年会, 39, O - 31,   2012年
  • 長さの異なる多層カーボンナノチューブの肺組織、細胞増殖および遺伝子発現への影響, 酒々井 眞澄,徐 結苟,深町 勝巳,二口 充,津田 洋幸, 日本毒性学会学術年会, 39, O - 25,   2012年
  • ナノマテリアルの慢性影響研究の重要性, 広瀬 明彦,高木 篤也,西村 哲治,津田 洋幸,坂本 義光,小縣 昭夫,中江 大,樋野 興夫,菅野 純, YAKUGAKU ZASSHI, 131, (2) 195 - 201,   2011年
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  • ナノマテリアルの有害性評価 : 毒性評価(誌上シンポジウム), 津田 洋幸,徳永 裕司,広瀬 明彦,菅野 純, 藥學雜誌, 128, (12) 1727 - 1732,   2008年
    DOI
  • 膵発がん幹細胞候補の同定, 津田 洋幸,深町 勝巳,徐 結苟,ALEXANDER David B.,上田 しのぶ,田中 創始,林 香月,落谷 孝広,斉藤 泉, 日本疾患モデル学会記録, 23, 36 - 42,   2007年
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  • 臨床と研究 日本の毒性学の現状と課題, 津田 洋幸, 現代医学, 54, (2) 257 - 266,   2006年
  • 多機能蛋白質ウシラクトフェリンによるがん予防の試み (特集:ラクトフェリンの機能と有用性(2)), 津田 洋幸,深町 勝巳,徐 結苟, 食品・食品添加物研究誌, 211, (9) 740 - 747,   2006年
  • 毒性学の役割, 津田 洋幸, 化学生物総合管理, 2, (2) 177 - 177,   2006年
  • 毒性学そして佐々木研究所, 津田 洋幸, 化学生物総合管理, 1, (3) 371 - 373,   2005年
  • 発がん高感受性ヒトｃ‐Ｈａ‐ｒａｓがん遺伝子トランスジェニックラット―新規高発がん動物モデルの開発―:―新規高発がん動物モデルの開発―, 大嶋 浩,深町 勝巳,松岡 洋一郎,濱口 哲也,大西 隆仁,高須賀 信夫,飯郷 正明,内藤 暁宏,津田 洋幸, 日本疾患モデル学会記録, 21, 45 - 53,   2005年
    DOI

競争的資金

  • トランスジェニックラットを用いた発がん機序の解析,   2000年 - 2004年

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