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井上 靖道イノウエ ヤスミチ

所属部署薬学研究科細胞情報学分野
職名准教授
メールアドレスyainouephar.nagoya-cu.ac.jp
ホームページURL
生年月日
Last Updated :2019/03/23

研究者基本情報

学歴

  •  - 1999年, 名古屋市立大学, 薬学部

学位

  • 名古屋市立大学大学院薬学研究科

所属学協会

  • 日本薬学会
  • 日本癌学会
  • 日本がん分子標的治療学会
  • 日本分子生物学会

経歴

  • 2004-2007 国立がんセンター研究所放射線研究部
  • 2007-2011 財団法人癌研究会癌研究所生化学部

研究活動情報

研究分野

  • 腫瘍学, 腫瘍生物学
  • 薬学, 生物系薬学

研究キーワード

    細胞周期, がん, 分子標的, 転写制御

論文

  • An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity., Ieda N, Itoh K, Inoue Y, Izumiya Y, Kawaguchi M, Miyata N, Nakagawa H, Bioorganic & medicinal chemistry letters, 29, (3) 353 - 356,   2019年02月, 査読有り
  • TRB1 negatively regulates gluconeogenesis by suppressing the transcriptional activity of FOXO1., Tsuzuki K, Itoh Y, Inoue Y, Hayashi H, FEBS letters,   2018年12月, 査読有り
  • Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway., Nagasaka M, Hashimoto R, Inoue Y, Ishiuchi K, Matsuno M, Itoh Y, Tokugawa M, Ohoka N, Morishita D, Mizukami H, Makino T, Hayashi H, Molecules (Basel, Switzerland), 23, (6) ,   2018年06月, 査読有り
  • The CDK inhibitor p21 is a novel target gene of ATF4 and contributes to cell survival under ER stress., Inoue Y, Kawachi S, Ohkubo T, Nagasaka M, Ito S, Fukuura K, Itoh Y, Ohoka N, Morishita D, Hayashi H, FEBS letters, 591, (21) 3682 - 3691,   2017年11月, 査読有り
  • TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription., Kawarada Y, Inoue Y, Kawasaki F, Fukuura K, Sato K, Tanaka T, Itoh Y, Hayashi H, Scientific reports, 6,   2016年10月, 査読有り
  • Tribbles-Related Protein Family Members as Regulators or Substrates of the Ubiquitin-Proteasome System in Cancer Development., Sakai S, Miyajima C, Uchida C, Itoh Y, Hayashi H, Inoue Y, Current cancer drug targets, 16, (2) 147 - 156,   2016年, 査読有り
  • Regulation of Epithelial-Mesenchymal Transition by E3 Ubiquitin Ligases and Deubiquitinase in Cancer., Inoue Y, Itoh Y, Sato K, Kawasaki F, Sumita C, Tanaka T, Morishita D, Hayashi H, Current cancer drug targets, 16, (2) 110 - 118,   2016年, 査読有り
  • TGF-β decreases the stability of IL-18-induced IFN-γ mRNA through the expression of TGF-β-induced tristetraprolin in KG-1 cells., Inoue Y, Abe K, Onozaki K, Hayashi H, Biological & pharmaceutical bulletin, 38, (4) 536 - 544,   2015年, 査読有り
  • Pseudokinase tribbles 1 (TRB1) negatively regulates tumor-suppressor activity of p53 through p53 deacetylation., Miyajima C, Inoue Y, Hayashi H, Biological & pharmaceutical bulletin, 38, (4) 618 - 624,   2015年, 査読有り
  • Positive Regulation of Interleukin-2 Expression by a Pseudokinase, Tribbles 1, in Activated T Cells., Miyajima C, Itoh Y, Inoue Y, Hayashi H, Biological & pharmaceutical bulletin, 38, (8) 1126 - 1133,   2015年, 査読有り
  • ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo., Dan S, Okamura M, Mukai Y, Yoshimi H, Inoue Y, Hanyu A, Sakaue-Sawano A, Imamura T, Miyawaki A, Yamori T, European journal of cancer (Oxford, England : 1990), 48, (6) 936 - 943,   2012年04月, 査読有り
  • The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis., Imamura T, Hikita A, Inoue Y, Breast cancer (Tokyo, Japan), 19, (2) 118 - 124,   2012年04月, 査読有り
  • Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1., Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T, The Journal of Biological Chemistry, 286, (8) 6311 - 20,   2011年02月, 査読有り
  • SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells., Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T, The Journal of Biological Chemistry, 284, (5) 3334 - 44,   2009年01月, 査読有り
  • Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts., Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T, PloS one, 5, (9) ,   2010年09月, 査読有り
  • Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells., Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T, The Journal of Biological Chemistry, 283, (51) 35660 - 7,   2008年12月, 査読有り
  • Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymaltransition., Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, Taya Y, Cancer Research, 68, (13) 5104 - 12,   2008年07月, 査読有り
  • Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage., Inoue Y, Kitagawa M, Taya Y, The EMBO Journal, 26, (8) 2083 - 93,   2007年04月, 査読有り
  • Regulation of TGF-beta family signaling by E3 ubiquitin ligases., Inoue Y, Imamura T, Cancer science, 99, (11) 2107 - 2112,   2008年11月, 査読有り
  • Smad3 is acetylated by p300/CBP to regulate its transactivation activity., Inoue Y, Itoh Y, Abe K, Okamoto T, Daitoku H, Fukamizu A, Onozaki K, Hayashi H, Oncogene, 26, (4) 500 - 8,   2007年01月, 査読有り
  • Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming growth factor-beta signaling., Inoue Y, Kitagawa M, Onozaki K, Hayashi H, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 24, (1) 43 - 54,   2004年01月, 査読有り
  • C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer., Hattori T, Ohoka N, Inoue Y, Hayashi H, Onozaki K, Oncogene, 22, (9) 1273 - 1280,   2003年03月, 査読有り
  • TGFbeta down-regulates IFN-gamma production in IL-18 treated NK cell line LNK5E6., Hayashi H, Inoue Y, Tsutsui H, Okamura H, Nakanishi K, Onozaki K, Biochemical and biophysical research communications, 300, (4) 980 - 985,   2003年01月, 査読有り

受賞

  •   2012年, 日本がん分子標的治療学会 研究奨励賞


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