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KUROYANAGI Gen

FacultyGraduate School of Medical Sciences Department of Rehabilitation Medicine
PositionAssistant Professor
Mailkokuryugenyahoo.co.jp
HomepageURL
Birthday
Last Updated :2019/10/12

Researcher Profile and Settings

Profile & Settings

    Research funding number:80790831

Association Memberships

  • JAPAN COLLEGE OF RHEUMATOLOGY
  • THE JAPANESE ORTHOPAEDIC ASSOCIATION

Research Activities

Research Areas

  • Clinical surgery, Orthopaedic surgery

Research Interests

    osteonecrosis, interleukin-6, osteoblast, ischemic osteonecrosis

Published Papers

  • Interleukin-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis in a murine model., Kuroyanagi G, Adapala NS, Yamaguchi R, Kamiya N, Deng Z, Aruwajoye O, Kutschke M, Chen E, Jo C, Ren Y, Kim HKW, Bone, 116, 221 - 231, 08 , Refereed
  • Treatment of Lateral Tibial Condylar Fractures Using Bioactive, Bioresorbable Forged Composites of Raw Particulate Unsintered Hydroxyapatite/Poly-L-Lactide Screws., Kuroyanagi G, Yoshihara H, Yamamoto N, Suzuki H, Yamada K, Yoshida Y, Otsuka T, Takada N, Orthopedics, 41, (3) e365 - e368, 05 , Refereed
  • Ristocetin induces phosphorylated-HSP27 (HSPB1) release from the platelets of type 2 DM patients: Anti-platelet agent-effect on the release., Tokuda H, Kuroyanagi G, Onuma T, Enomoto Y, Doi T, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O, Biomedical reports, 8, (4) 365 - 372, 04 , Refereed
  • Suppression by HSP90 inhibitors of BMP‑4‑stimulated osteoprotegerin synthesis in osteoblasts: Attenuation of p70 S6 kinase., Kawabata T, Otsuka T, Fujita K, Kainuma S, Yamamoto N, Kuroyanagi G, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Molecular medicine reports, 16, (6) 8507 - 8512, 12 , Refereed
  • Amplification by (‑)‑epigallocatechin gallate of prostaglandin F2α‑stimulated synthesis of osteoprotegerin in osteoblasts., Sakai G, Otsuka T, Fujita K, Kainuma S, Kuroyanagi G, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Molecular medicine reports, 16, (5) 6376 - 6381, 11 , Refereed
  • Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts., Kainuma S, Tokuda H, Yamamoto N, Kuroyanagi G, Fujita K, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, International journal of molecular medicine, 40, (4) 1057 - 1066, 10 , Refereed
  • Resveratrol suppresses thyroid hormone‑induced osteocalcin synthesis in osteoblasts., Fujita K, Tokuda H, Kainuma S, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T, Molecular medicine reports, 16, (3) 2881 - 2886, 09 , Refereed
  • Targeted Disruption of NF1 in Osteocytes Increases FGF23 and Osteoid With Osteomalacia-like Bone Phenotype., Kamiya N, Yamaguchi R, Aruwajoye O, Kim AJ, Kuroyanagi G, Phipps M, Adapala NS, Feng JQ, Kim HK, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 32, (8) 1716 - 1726, 08 , Refereed
  • (-)-Epigallocatechin gallate but not chlorogenic acid upregulates osteoprotegerin synthesis through regulation of bone morphogenetic protein-4 in osteoblasts., Fujita K, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Experimental and therapeutic medicine, 14, (1) 417 - 423, 07 , Refereed
  • Incretins amplify TNF-α-stimulated IL-6 synthesis in osteoblasts: Suppression of the IκB/NF-κB pathway., Fujita K, Tokuda H, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T, International journal of molecular medicine, 39, (4) 1053 - 1060, 04 , Refereed
  • Attenuation of prostaglandin E1‑induced osteoprotegerin synthesis in osteoblasts by normoxic HIF inducers., Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, Molecular medicine reports, 15, (4) 1847 - 1852, 04 , Refereed
  • (-)-Epigallocatechin gallate synergistically potentiates prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts., Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T, Prostaglandins & other lipid mediators, 128-129, 27 - 33, 01 , Refereed
  • HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts., Fujita K, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, PloS one, 12, (5) , Refereed
  • Heat shock protein 22 (HSPB8) limits TGF-β-stimulated migration of osteoblasts., Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Matsushima-Nishiwaki R, Fujita K, Kozawa O, Otsuka T, Molecular and cellular endocrinology, 436, 1 - 9, 11 , Refereed
  • AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: Suppression of HSP27 phosphorylation via p44/p42 MAP kinase., Tsujimoto M, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Matsushima-Nishiwaki R, Onuma T, Iida Y, Kojima A, Sawada S, Doi T, Enomoto Y, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Kozawa O, Iwama T, Experimental and therapeutic medicine, 12, (2) 1107 - 1112, 08 , Refereed
  • Possible involvement of AMP-activated protein kinase in PGE1-induced synthesis of osteoprotegerin in osteoblasts., Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Experimental and therapeutic medicine, 11, (5) 2042 - 2048, 05 , Refereed
  • Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients., Tokuda H, Kuroyanagi G, Tsujimoto M, Matsushima-Nishiwaki R, Akamatsu S, Enomoto Y, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O, International journal of molecular sciences, 17, (5) , 05 , Refereed
  • Regulation by AMP-activated protein kinase of PGE2-induced osteoprotegerin synthesis in osteoblasts., Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Molecular medicine reports, 13, (4) 3363 - 3369, 04 , Refereed
  • Mimosine suppresses the PGF2α-induced synthesis of osteoprotegerin but not interleukin-6 in osteoblasts., Kuroyanagi G, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, International journal of molecular medicine, 37, (2) 533 - 541, 02 , Refereed
  • Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase., Tsujimoto M, Kuroyanagi G, Matsushima-Nishiwaki R, Kito Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T, PloS one, 11, (2) , Refereed
  • Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-α-stimulated interleukin-6 synthesis in osteoblasts., Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, International journal of molecular medicine, 36, (6) 1707 - 1712, 12 , Refereed
  • PGD2 stimulates osteoprotegerin synthesis via AMP-activated protein kinase in osteoblasts: Regulation of ERK and SAPK/JNK., Kainuma S, Tokuda H, Kuroyanagi G, Yamamoto N, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, Prostaglandins, leukotrienes, and essential fatty acids, 101, 23 - 29, 10 , Refereed
  • Resveratrol amplifies BMP-4-stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts., Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Otsuka T, Molecular medicine reports, 12, (3) 3849 - 3854, 09 , Refereed
  • Unphosphorylated HSP27 (HSPB1) regulates the translation initiation process via a direct association with eIF4E in osteoblasts., Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, International journal of molecular medicine, 36, (3) 881 - 889, 09 , Refereed
  • αB-crystallin reduces ristocetin‑induced soluble CD40 ligand release in human platelets: suppression of thromboxane A2 generation., Tsujimoto M, Doi T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Iida Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T, Molecular medicine reports, 12, (1) 357 - 362, 07 , Refereed
  • Resveratrol suppresses TGF-β-induced VEGF synthesis in osteoblasts: Inhibition of the p44/p42 MAPKs and SAPK/JNK pathways., Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Experimental and therapeutic medicine, 9, (6) 2303 - 2310, 06 , Refereed
  • Rac limits TGF-β-induced VEGF synthesis in osteoblasts., Yamamoto N, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H, Molecular and cellular endocrinology, 405, 35 - 41, 04 , Refereed
  • Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration., Suzuki M, Matsushima-Nishiwaki R, Kuroyanagi G, Suzuki N, Takamatsu R, Furui T, Yoshimi N, Kozawa O, Morishige K, Archives of biochemistry and biophysics, 571, 40 - 49, 04 , Refereed
  • Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase., Iida Y, Doi T, Tokuda H, Matsushima-Nishiwaki R, Tsujimoto M, Kuroyanagi G, Yamamoto N, Enomoto Y, Tanabe K, Otsuka T, Iwama T, Ogura S, Kozawa O, Iida H, Prostaglandins, leukotrienes, and essential fatty acids, 94, 73 - 81, 03 , Refereed
  • Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: suppression of stress-activated protein kinase/c-Jun N-terminal kinase., Yamamoto N, Otsuka T, Kuroyanagi G, Kondo A, Kainuma S, Nakakami A, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Prostaglandins & other lipid mediators, 116-117, 57 - 63, 01 , Refereed
  • Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients., Tokuda H, Kuroyanagi G, Tsujimoto M, Enomoto Y, Matsushima-Nishiwaki R, Onuma T, Kojima A, Doi T, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Iwama T, Tanikawa T, Ishikawa K, Kojima K, Kozawa O, PloS one, 10, (6) , Refereed
  • Regulation by resveratrol of prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts., Yamamoto N, Tokuda H, Kuroyanagi G, Mizutani J, Matsushima-Nishiwaki R, Kondo A, Kozawa O, Otsuka T, International journal of molecular medicine, 34, (5) 1439 - 1445, 11 , Refereed
  • Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts., Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Nakakami A, Mizutani J, Kozawa O, Tokuda H, International journal of molecular sciences, 15, (10) 17886 - 17900, 10 , Refereed
  • Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts., Kuroyanagi G, Mizutani J, Kondo A, Yamamoto N, Matsushima-Nishiwaki R, Otsuka T, Kozawa O, Tokuda H, Prostaglandins, leukotrienes, and essential fatty acids, 91, (3) 73 - 80, 09 , Refereed
  • Involvement of Rac in thromboxane A2‑induced human platelet activation: regulation of sCD40 ligand release and PDGF‑AB secretion., Kageyama Y, Doi T, Matsushima-Nishiwaki R, Iida Y, Akamatsu S, Kondo A, Kuroyanagi G, Yamamoto N, Mizutani J, Otsuka T, Tokuda H, Iida H, Kozawa O, Ogura S, Molecular medicine reports, 10, (1) 107 - 112, 07 , Refereed
  • Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts: suppression of S6 kinase., Kondo A, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Tokuda H, International journal of molecular medicine, 33, (4) 1013 - 1018, 04 , Refereed
  • Rho-kinase limits BMP-4-stimulated osteocalcin synthesis in osteoblasts: regulation of the p38 MAP kinase pathway., Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kuroyanagi G, Yamamoto N, Mizutani J, Kozawa O, Otsuka T, Life sciences, 96, (1-2) 18 - 25, 02 , Refereed
  • Resveratrol suppresses prostaglandin F(2α)-induced osteoprotegerin synthesis in osteoblasts: inhibition of the MAP kinase signaling., Kuroyanagi G, Tokuda H, Matsushima-Nishiwaki R, Kondo A, Mizutani J, Kozawa O, Otsuka T, Archives of biochemistry and biophysics, 542, 39 - 45, 01 , Refereed
  • (-)-Epigallocatechin gallate amplifies interleukin-1-stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells., Kuroyanagi G, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Tokuda H, Biochimie, 95, (10) 1933 - 1938, 10 , Refereed
  • Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets., Kageyama Y, Doi T, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Otsuka T, Tokuda H, Kozawa O, Ogura S, International journal of molecular medicine, 32, (4) 813 - 818, 10 , Refereed
  • Leg lymphedema caused by iliopectineal bursitis associated with destruction of a rheumatoid hip joint: A case report., Kuroyanagi G, Yamada K, Imaizumi T, Mizutani J, Wada I, Kozawa O, Tokuda H, Otsuka T, Experimental and therapeutic medicine, 6, (4) 887 - 890, 10 , Refereed
  • Unphosphorylated heat shock protein 27 suppresses fibroblast growth factor‑2‑stimulated vascular endothelial growth factor release in osteoblasts., Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kato K, Kuroyanagi G, Mizutani J, Fukuoka M, Wada I, Kozawa O, Otsuka T, Molecular medicine reports, 8, (2) 691 - 695, 08 , Refereed
  • Inhibition of SAPK/JNK leads to enhanced IL-1-induced IL-6 synthesis in osteoblasts., Kondo A, Otsuka T, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Wada I, Kozawa O, Tokuda H, Archives of biochemistry and biophysics, 535, (2) 227 - 233, 07 , Refereed
  • Thrombopoietin amplifies ADP-induced HSP27 phosphorylation in human platelets: importance of pre-treatment., Cuong NT, Doi T, Matsushima-Nishiwaki R, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Wada I, Otsuka T, Tokuda H, Kozawa O, Ogura S, International journal of molecular medicine, 31, (6) 1291 - 1297, 06 , Refereed
  • AMP-activated protein kinase regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts., Kondo A, Otsuka T, Kato K, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Tokuda H, Kozawa O, International journal of molecular medicine, 31, (6) 1457 - 1462, 06 , Refereed
  • Rho-kinase negatively regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts., Kondo A, Tokuda H, Kato K, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Kozawa O, Otsuka T, Biochimie, 95, (4) 719 - 724, 04 , Refereed
  • AMP-activated protein kinase inhibitor decreases prostaglandin F2α-stimulated interleukin-6 synthesis through p38 MAP kinase in osteoblasts., Kondo A, Otsuka T, Kato K, Natsume H, Kuroyanagi G, Mizutani J, Ito Y, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, International journal of molecular medicine, 30, (6) 1487 - 1492, 12 , Refereed

Awards & Honors

  •   2017 09 , American Society for Bone and Mineral Research, 2017 ASBMR Young Investigator Award


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