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黒柳 元クロヤナギ ゲン

所属部署医学研究科リハビリテーション医学分野
職名助教
メールアドレスkokuryugenyahoo.co.jp
ホームページURL
生年月日
Last Updated :2019/06/01

研究者基本情報

基本情報

    科研費研究者番号:80790831

所属学協会

  • 日本骨免疫学会
  • 日本人工関節学会
  • 日本骨粗鬆症学会
  • 日本リウマチ学会
  • 日本整形外科学会

研究活動情報

研究分野

  • 外科系臨床医学, 整形外科学

研究キーワード

    骨壊死, インターロイキン6, 骨芽細胞, 虚血性骨壊死

論文

  • Interleukin-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis in a murine model., Kuroyanagi G, Adapala NS, Yamaguchi R, Kamiya N, Deng Z, Aruwajoye O, Kutschke M, Chen E, Jo C, Ren Y, Kim HKW, Bone, 116, 221 - 231,   2018年08月, 査読有り
  • Treatment of Lateral Tibial Condylar Fractures Using Bioactive, Bioresorbable Forged Composites of Raw Particulate Unsintered Hydroxyapatite/Poly-L-Lactide Screws., Kuroyanagi G, Yoshihara H, Yamamoto N, Suzuki H, Yamada K, Yoshida Y, Otsuka T, Takada N, Orthopedics, 41, (3) e365 - e368,   2018年05月, 査読有り
  • Ristocetin induces phosphorylated-HSP27 (HSPB1) release from the platelets of type 2 DM patients: Anti-platelet agent-effect on the release., Tokuda H, Kuroyanagi G, Onuma T, Enomoto Y, Doi T, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O, Biomedical reports, 8, (4) 365 - 372,   2018年04月, 査読有り
  • Suppression by HSP90 inhibitors of BMP‑4‑stimulated osteoprotegerin synthesis in osteoblasts: Attenuation of p70 S6 kinase., Kawabata T, Otsuka T, Fujita K, Kainuma S, Yamamoto N, Kuroyanagi G, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Molecular medicine reports, 16, (6) 8507 - 8512,   2017年12月, 査読有り
  • Amplification by (‑)‑epigallocatechin gallate of prostaglandin F2α‑stimulated synthesis of osteoprotegerin in osteoblasts., Sakai G, Otsuka T, Fujita K, Kainuma S, Kuroyanagi G, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Molecular medicine reports, 16, (5) 6376 - 6381,   2017年11月, 査読有り
  • Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts., Kainuma S, Tokuda H, Yamamoto N, Kuroyanagi G, Fujita K, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, International journal of molecular medicine, 40, (4) 1057 - 1066,   2017年10月, 査読有り
  • Resveratrol suppresses thyroid hormone‑induced osteocalcin synthesis in osteoblasts., Fujita K, Tokuda H, Kainuma S, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T, Molecular medicine reports, 16, (3) 2881 - 2886,   2017年09月, 査読有り
  • Targeted Disruption of NF1 in Osteocytes Increases FGF23 and Osteoid With Osteomalacia-like Bone Phenotype., Kamiya N, Yamaguchi R, Aruwajoye O, Kim AJ, Kuroyanagi G, Phipps M, Adapala NS, Feng JQ, Kim HK, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 32, (8) 1716 - 1726,   2017年08月, 査読有り
  • (-)-Epigallocatechin gallate but not chlorogenic acid upregulates osteoprotegerin synthesis through regulation of bone morphogenetic protein-4 in osteoblasts., Fujita K, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Experimental and therapeutic medicine, 14, (1) 417 - 423,   2017年07月, 査読有り
  • Incretins amplify TNF-α-stimulated IL-6 synthesis in osteoblasts: Suppression of the IκB/NF-κB pathway., Fujita K, Tokuda H, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T, International journal of molecular medicine, 39, (4) 1053 - 1060,   2017年04月, 査読有り
  • Attenuation of prostaglandin E1‑induced osteoprotegerin synthesis in osteoblasts by normoxic HIF inducers., Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, Molecular medicine reports, 15, (4) 1847 - 1852,   2017年04月, 査読有り
  • (-)-Epigallocatechin gallate synergistically potentiates prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts., Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T, Prostaglandins & other lipid mediators, 128-129, 27 - 33,   2017年01月, 査読有り
  • HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts., Fujita K, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, PloS one, 12, (5) ,   2017年, 査読有り
  • Heat shock protein 22 (HSPB8) limits TGF-β-stimulated migration of osteoblasts., Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Matsushima-Nishiwaki R, Fujita K, Kozawa O, Otsuka T, Molecular and cellular endocrinology, 436, 1 - 9,   2016年11月, 査読有り
  • AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: Suppression of HSP27 phosphorylation via p44/p42 MAP kinase., Tsujimoto M, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Matsushima-Nishiwaki R, Onuma T, Iida Y, Kojima A, Sawada S, Doi T, Enomoto Y, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Kozawa O, Iwama T, Experimental and therapeutic medicine, 12, (2) 1107 - 1112,   2016年08月, 査読有り
  • Possible involvement of AMP-activated protein kinase in PGE1-induced synthesis of osteoprotegerin in osteoblasts., Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Experimental and therapeutic medicine, 11, (5) 2042 - 2048,   2016年05月, 査読有り
  • Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients., Tokuda H, Kuroyanagi G, Tsujimoto M, Matsushima-Nishiwaki R, Akamatsu S, Enomoto Y, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O, International journal of molecular sciences, 17, (5) ,   2016年05月, 査読有り
  • Regulation by AMP-activated protein kinase of PGE2-induced osteoprotegerin synthesis in osteoblasts., Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Molecular medicine reports, 13, (4) 3363 - 3369,   2016年04月, 査読有り
  • Mimosine suppresses the PGF2α-induced synthesis of osteoprotegerin but not interleukin-6 in osteoblasts., Kuroyanagi G, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, International journal of molecular medicine, 37, (2) 533 - 541,   2016年02月, 査読有り
  • Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase., Tsujimoto M, Kuroyanagi G, Matsushima-Nishiwaki R, Kito Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T, PloS one, 11, (2) ,   2016年, 査読有り
  • Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-α-stimulated interleukin-6 synthesis in osteoblasts., Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, International journal of molecular medicine, 36, (6) 1707 - 1712,   2015年12月, 査読有り
  • PGD2 stimulates osteoprotegerin synthesis via AMP-activated protein kinase in osteoblasts: Regulation of ERK and SAPK/JNK., Kainuma S, Tokuda H, Kuroyanagi G, Yamamoto N, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, Prostaglandins, leukotrienes, and essential fatty acids, 101, 23 - 29,   2015年10月, 査読有り
  • Resveratrol amplifies BMP-4-stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts., Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Otsuka T, Molecular medicine reports, 12, (3) 3849 - 3854,   2015年09月, 査読有り
  • Unphosphorylated HSP27 (HSPB1) regulates the translation initiation process via a direct association with eIF4E in osteoblasts., Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Otsuka T, International journal of molecular medicine, 36, (3) 881 - 889,   2015年09月, 査読有り
  • αB-crystallin reduces ristocetin‑induced soluble CD40 ligand release in human platelets: suppression of thromboxane A2 generation., Tsujimoto M, Doi T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Iida Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T, Molecular medicine reports, 12, (1) 357 - 362,   2015年07月, 査読有り
  • Resveratrol suppresses TGF-β-induced VEGF synthesis in osteoblasts: Inhibition of the p44/p42 MAPKs and SAPK/JNK pathways., Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Experimental and therapeutic medicine, 9, (6) 2303 - 2310,   2015年06月, 査読有り
  • Rac limits TGF-β-induced VEGF synthesis in osteoblasts., Yamamoto N, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H, Molecular and cellular endocrinology, 405, 35 - 41,   2015年04月, 査読有り
  • Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration., Suzuki M, Matsushima-Nishiwaki R, Kuroyanagi G, Suzuki N, Takamatsu R, Furui T, Yoshimi N, Kozawa O, Morishige K, Archives of biochemistry and biophysics, 571, 40 - 49,   2015年04月, 査読有り
  • Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase., Iida Y, Doi T, Tokuda H, Matsushima-Nishiwaki R, Tsujimoto M, Kuroyanagi G, Yamamoto N, Enomoto Y, Tanabe K, Otsuka T, Iwama T, Ogura S, Kozawa O, Iida H, Prostaglandins, leukotrienes, and essential fatty acids, 94, 73 - 81,   2015年03月, 査読有り
  • Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: suppression of stress-activated protein kinase/c-Jun N-terminal kinase., Yamamoto N, Otsuka T, Kuroyanagi G, Kondo A, Kainuma S, Nakakami A, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, Prostaglandins & other lipid mediators, 116-117, 57 - 63,   2015年01月, 査読有り
  • Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients., Tokuda H, Kuroyanagi G, Tsujimoto M, Enomoto Y, Matsushima-Nishiwaki R, Onuma T, Kojima A, Doi T, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Iwama T, Tanikawa T, Ishikawa K, Kojima K, Kozawa O, PloS one, 10, (6) ,   2015年, 査読有り
  • Regulation by resveratrol of prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts., Yamamoto N, Tokuda H, Kuroyanagi G, Mizutani J, Matsushima-Nishiwaki R, Kondo A, Kozawa O, Otsuka T, International journal of molecular medicine, 34, (5) 1439 - 1445,   2014年11月, 査読有り
  • Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts., Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Nakakami A, Mizutani J, Kozawa O, Tokuda H, International journal of molecular sciences, 15, (10) 17886 - 17900,   2014年10月, 査読有り
  • Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts., Kuroyanagi G, Mizutani J, Kondo A, Yamamoto N, Matsushima-Nishiwaki R, Otsuka T, Kozawa O, Tokuda H, Prostaglandins, leukotrienes, and essential fatty acids, 91, (3) 73 - 80,   2014年09月, 査読有り
  • Involvement of Rac in thromboxane A2‑induced human platelet activation: regulation of sCD40 ligand release and PDGF‑AB secretion., Kageyama Y, Doi T, Matsushima-Nishiwaki R, Iida Y, Akamatsu S, Kondo A, Kuroyanagi G, Yamamoto N, Mizutani J, Otsuka T, Tokuda H, Iida H, Kozawa O, Ogura S, Molecular medicine reports, 10, (1) 107 - 112,   2014年07月, 査読有り
  • Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts: suppression of S6 kinase., Kondo A, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Tokuda H, International journal of molecular medicine, 33, (4) 1013 - 1018,   2014年04月, 査読有り
  • Rho-kinase limits BMP-4-stimulated osteocalcin synthesis in osteoblasts: regulation of the p38 MAP kinase pathway., Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kuroyanagi G, Yamamoto N, Mizutani J, Kozawa O, Otsuka T, Life sciences, 96, (1-2) 18 - 25,   2014年02月, 査読有り
  • Resveratrol suppresses prostaglandin F(2α)-induced osteoprotegerin synthesis in osteoblasts: inhibition of the MAP kinase signaling., Kuroyanagi G, Tokuda H, Matsushima-Nishiwaki R, Kondo A, Mizutani J, Kozawa O, Otsuka T, Archives of biochemistry and biophysics, 542, 39 - 45,   2014年01月, 査読有り
  • (-)-Epigallocatechin gallate amplifies interleukin-1-stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells., Kuroyanagi G, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Tokuda H, Biochimie, 95, (10) 1933 - 1938,   2013年10月, 査読有り
  • Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets., Kageyama Y, Doi T, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Otsuka T, Tokuda H, Kozawa O, Ogura S, International journal of molecular medicine, 32, (4) 813 - 818,   2013年10月, 査読有り
  • Leg lymphedema caused by iliopectineal bursitis associated with destruction of a rheumatoid hip joint: A case report., Kuroyanagi G, Yamada K, Imaizumi T, Mizutani J, Wada I, Kozawa O, Tokuda H, Otsuka T, Experimental and therapeutic medicine, 6, (4) 887 - 890,   2013年10月, 査読有り
  • Unphosphorylated heat shock protein 27 suppresses fibroblast growth factor‑2‑stimulated vascular endothelial growth factor release in osteoblasts., Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kato K, Kuroyanagi G, Mizutani J, Fukuoka M, Wada I, Kozawa O, Otsuka T, Molecular medicine reports, 8, (2) 691 - 695,   2013年08月, 査読有り
  • Inhibition of SAPK/JNK leads to enhanced IL-1-induced IL-6 synthesis in osteoblasts., Kondo A, Otsuka T, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Wada I, Kozawa O, Tokuda H, Archives of biochemistry and biophysics, 535, (2) 227 - 233,   2013年07月, 査読有り
  • Thrombopoietin amplifies ADP-induced HSP27 phosphorylation in human platelets: importance of pre-treatment., Cuong NT, Doi T, Matsushima-Nishiwaki R, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Wada I, Otsuka T, Tokuda H, Kozawa O, Ogura S, International journal of molecular medicine, 31, (6) 1291 - 1297,   2013年06月, 査読有り
  • AMP-activated protein kinase regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts., Kondo A, Otsuka T, Kato K, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Tokuda H, Kozawa O, International journal of molecular medicine, 31, (6) 1457 - 1462,   2013年06月, 査読有り
  • Rho-kinase negatively regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts., Kondo A, Tokuda H, Kato K, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Kozawa O, Otsuka T, Biochimie, 95, (4) 719 - 724,   2013年04月, 査読有り
  • AMP-activated protein kinase inhibitor decreases prostaglandin F2α-stimulated interleukin-6 synthesis through p38 MAP kinase in osteoblasts., Kondo A, Otsuka T, Kato K, Natsume H, Kuroyanagi G, Mizutani J, Ito Y, Matsushima-Nishiwaki R, Kozawa O, Tokuda H, International journal of molecular medicine, 30, (6) 1487 - 1492,   2012年12月, 査読有り

受賞

  •   2017年09月, アメリカ骨代謝, 2017 ASBMR Young Investigator Award


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