Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2010 -2011
Author : INOUE Yasumichi
p53 and TGF-βsignaling are well known as tumor suppressors which regulate cytostasis and apoptosis, whereas critical roles of mutant p53 and TGF-βsignaling in cancer metastasis have now emerged. In this project, we have demonstrated that proto-oncoprotein Ski, which is an important negative regulator of TGF-βsignaling, interacts with p53 and attenuates the biological functions of p53.Moreover, we have shown that Ski may prove to be an especially valuable therapeutic target. Also, we identified that histone methyltransferase SET8, which represses the biological functions of p53, also negatively regulates TGF-βsignaling.