Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2018/04 -2020/03
Author : Masanori HIJIOKA
We focused on the bioactive lipid mediators that regulate neutrophil migration activity, because leakage of blood constituents and immune cells, especially neutrophils worsen the severity of tissue damages in intracerebral hemorrhage (ICH) brain. We revealed that leukotriene B4 (LTB4) transiently increased, and LTB4 were involved in pathomechanisms of ICH such as microglial activation, and neutrophil migration. Furthermore, we focused on lipoxinA4 (LXA4), a bioactive lipid mediator that biosynthesis by 5-lipoxygenase as same as LTB4. LXA4 and its receptor agonist attenuated microglial activation, neutrophil infiltration, and motor deficits in ICH mice.