Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2014 -2015
Author : Morita Shoko
The sensory circumventricular organs (CVOs), which comprise the organum vasculosum of the lamina terminalis, the subfornical organ and the area postrema, lack a typical blood-brain barrier and monitor directly blood-derived information to regulate body fluid homeostasis, inflammation, feeding, nausea and vomiting. Until now, almost nothing has been documented about vascular features of the sensory CVOs except fenestration of vascular endothelial cells. I demonstrated that continuous angiogenesis occurs in the adult sensory CVOs. My data indicate that continuous angiogenesis is dependent on vascular endothelial growth factor signaling and responsible for the dynamic plasticity of vascular structure and permeability.