Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2021/04 -2024/03
Author : Fujii Keiichiro
In fifteen IVL cases, translocations of BCL2, BCL6, and MYC genes, and amplification of PD-L1 gene were analyzed using a FICTION-WSI method. None of the cases had translocations, but some showed aberrant FISH signal gains. This observation may be related to IVL lymphomagenesis, but further investigations may be necessary. We plan to continue our research even after the research period ends.
To gain a better understanding of DLBCL and to optimize individualized prognosis assessment, we developed nomograms to predict the survival of DLBCL patients. We also included MYD88 and CD79B mutations in the prognostic model.