Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2013/04 -2016/03
Author : Mase Mitsuhito; MORI Etsuro; MIYATI Toshiaki; AOYAMA Kiminori; YAMADA Kazuo
In order to clarify the origin and turnover of water molecules in CSF, dynamic PET study was performed using H215O. Normal volunteers (n=11) and patients with definite idiopathic normal pressure hydrocephalus (iNPH, n=2) were included. Dynamic PET data were obtained for 8 minutes after intravenous bolus injection of H215O (500MBq) in saline. Voxels of interest (VOI) were set in the internal carotid artery (ICA), cortical gray matter (GM), white matter (WM) lateral ventricle (LV) based on MR T1 (3D) images. The time and relative radio activity (RAA) curves of each VOI were analyzed.
The activities in the whole brain structures decreased gradually. On the contrary, the activity of LV increased gradually until the end of the measurement {27% of the whole brain parenchyma (GM+WM) activity at 8 minutes}. The RRA of LV in iNPH tended to be lower compared to the normal control.
This study showed very fast movement of water molecules from artery to brain parenchyma and ventricular CSF.