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田尻 直輝タジリ ナオキ

所属部署医学研究科脳神経生理学分野
職名准教授
メールアドレスntajirimed.nagoya-cu.ac.jp
ホームページURLhttp://researchmap.jp/tajirin23/
生年月日
Last Updated :2019/09/20

研究者基本情報

学歴

  • 2006年04月 - 2010年03月, 岡山大学大学院 医歯薬学総合研究科 神経病態外科学(脳神経外科)  
  • 2004年04月 - 2006年03月, 岡山大学大学院 医歯学総合研究科 細胞組織学 
  • 2000年04月 - 2004年03月, 吉備国際大学, 保健科学部, 理学療法学科

学位

  • 医学博士, 岡山大学

所属学協会

  • 日本医学英語教育学会
  • 日本理学療法士協会
  • 日本ニューロリハビリテーション学会
  • 日本分子脳神経外科学会
  • 日本神経科学学会
  • 米国神経修復学会
  • 北米神経科学会

経歴

  •   2018年04月 - 現在, 名古屋市立大学大学院 医学研究科・医学部, 脳神経生理学, 准教授
  •   2016年06月 - 現在, 岡山大学 医学部, 脳神経外科学, 客員研究員
  •   2016年04月 - 2018年03月, 吉備国際大学 心理学部 心理学科 大学院心理学研究科, 准教授
  •   2013年04月 - 2016年04月, 米国 南フロリダ大学 医学部, 理学療法学科、脳神経外科(兼任), 助教
  •   2010年03月 - 2013年04月, 米国 南フロリダ大学 医学部, 脳神経外科, 博士研究員(ポスドク)

研究活動情報

研究分野

  • 外科系臨床医学, 脳神経外科学
  • 神経科学, 神経生理学・神経科学一般
  • 基礎医学, 生理学一般

研究キーワード

    中枢神経疾患, 脳神経科学, 再生医学・再生医療, 細胞移植, リハビリテーション科学

論文

  • Electrical Stimulation Enhances Migratory Ability of Transplanted Bone Marrow Stromal Cells in a Rodent Ischemic Stroke Model., Morimoto J, Yasuhara T, Kameda M, Umakoshi M, Kin I, Kuwahara K, Kin K, Okazaki M, Takeuchi H, Sasaki T, Toyoshima A, Tajiri N, Agari T, Borlongan CV, Date I, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46, (1) 57 - 68,   2018年03月, 査読有り
  • NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats., Tajiri N, Quach DM, Kaneko Y, Wu S, Lee D, Lam T, Hayama KL, Hazel TG, Johe K, Wu MC, Borlongan CV, Journal of cellular physiology, 232, (10) 2731 - 2740,   2017年10月, 査読有り
  • Cell Therapy for Parkinson's Disease., Yasuhara T, Kameda M, Sasaki T, Tajiri N, Date I, Cell transplantation, 26, (9) 1551 - 1559,   2017年09月, 査読有り
  • Hippocampal neurogenesis of Wistar Kyoto rats is congenitally impaired and correlated with stress resistance., Kin K, Yasuhara T, Kameda M, Agari T, Sasaki T, Morimoto J, Okazaki M, Umakoshi M, Kuwahara K, Kin I, Tajiri N, Date I, Behavioural brain research, 329, 148 - 156,   2017年06月, 査読有り
  • Increased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury., Acosta SA, Tajiri N, Sanberg PR, Kaneko Y, Borlongan CV, Journal of cellular physiology, 232, (3) 665 - 677,   2017年03月, 査読有り
  • Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells., Kaneko Y, Pappas C, Malapira T, Vale FĹ, Tajiri N, Borlongan CV, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 41, (3) 947 - 959,   2017年, 査読有り
  • Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro., Kaneko Y, Pappas C, Tajiri N, Borlongan CV, Scientific reports, 6,   2016年10月, 査読有り
  • Blood-Spinal Cord Barrier Alterations in Subacute and Chronic Stages of a Rat Model of Focal Cerebral Ischemia., Garbuzova-Davis S, Haller E, Tajiri N, Thomson A, Barretta J, Williams SN, Haim ED, Qin H, Frisina-Deyo A, Abraham JV, Sanberg PR, Van Loveren H, Borlongan CV, Journal of neuropathology and experimental neurology, 75, (7) 673 - 688,   2016年07月, 査読有り
  • Cyclosporine A Treatment Abrogates Ischemia-Induced Neuronal Cell Death by Preserving Mitochondrial Integrity through Upregulation of the Parkinson's Disease-Associated Protein DJ-1., Tajiri N, Borlongan CV, Kaneko Y, CNS neuroscience & therapeutics, 22, (7) 602 - 610,   2016年07月, 査読有り
  • A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus., Tajiri N, De La Peña I, Acosta SA, Kaneko Y, Tamir S, Landesman Y, Carlson R, Shacham S, Borlongan CV, CNS neuroscience & therapeutics, 22, (4) 306 - 315,   2016年04月, 査読有り
  • Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy., Kaneko Y, Sullivan R, Dailey T, Vale FL, Tajiri N, Borlongan CV, Molecular neurobiology, 53, (3) 1874 - 1883,   2016年04月, 査読有り
  • Stroke and cardiac cell death: Two peas in a pod., Gonzales-Portillo C, Ishikawa H, Shinozuka K, Tajiri N, Kaneko Y, Borlongan CV, Clinical neurology and neurosurgery, 142, 145 - 147,   2016年03月, 査読有り
  • Brain Region-Specific Histopathological Effects of Varying Trajectories of Controlled Cortical Impact Injury Model of Traumatic Brain Injury., Pabón MM, Acosta S, Guedes VA, Tajiri N, Kaneko Y, Borlongan CV, CNS neuroscience & therapeutics, 22, (3) 200 - 211,   2016年03月, 査読有り
  • Breaking the Blood-Brain Barrier With Mannitol to Aid Stem Cell Therapeutics in the Chronic Stroke Brain., Tajiri N, Lee JY, Acosta S, Sanberg PR, Borlongan CV, Cell transplantation, 25, (8) 1453 - 1460,   2016年, 査読有り
  • Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy., Duncan K, Gonzales-Portillo GS, Acosta SA, Kaneko Y, Borlongan CV, Tajiri N, Brain research, 1623, 160 - 165,   2015年10月, 査読有り
  • Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping., Lawton C, Acosta S, Watson N, Gonzales-Portillo C, Diamandis T, Tajiri N, Kaneko Y, Sanberg PR, Borlongan CV, Neural regeneration research, 10, (9) 1359 - 1362,   2015年09月, 査読有り
  • Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke., Acosta SA, Tajiri N, Hoover J, Kaneko Y, Borlongan CV, Stroke, 46, (9) 2616 - 2627,   2015年09月, 査読有り
  • A possible new focus for stroke treatment - migrating stem cells., Sullivan R, Duncan K, Dailey T, Kaneko Y, Tajiri N, Borlongan CV, Expert opinion on biological therapy, 15, (7) 949 - 958,   2015年07月, 査読有り
  • An update on the use of melatonin as a stroke therapeutic., Gonzales-Portillo GS, Lozano D, Aguirre D, Reyes S, Borlongan CV, Tajiri N, Kaneko Y, Minerva medica, 106, (3) 169 - 175,   2015年06月, 査読有り
  • Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease., Acosta SA, Tajiri N, de la Pena I, Bastawrous M, Sanberg PR, Kaneko Y, Borlongan CV, Journal of cellular physiology, 230, (5) 1024 - 1032,   2015年05月, 査読有り
  • Developments in intracerebral stem cell grafts., Reyes S, Tajiri N, Borlongan CV, Expert review of neurotherapeutics, 15, (4) 381 - 393,   2015年04月, 査読有り
  • Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis., dela Peña IC, Yoo A, Tajiri N, Acosta SA, Ji X, Kaneko Y, Borlongan CV, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35, (2) 338 - 346,   2015年02月, 査読有り
  • No pain, no gain: lack of exercise obstructs neurogenesis., Watson N, Ji X, Yasuhara T, Date I, Kaneko Y, Tajiri N, Borlongan CV, Cell transplantation, 24, (4) 591 - 597,   2015年, 査読有り
  • Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities., Lozano D, Gonzales-Portillo GS, Acosta S, de la Pena I, Tajiri N, Kaneko Y, Borlongan CV, Neuropsychiatric disease and treatment, 11, 97 - 106,   2015年, 査読有り
  • Bone marrow-derived stem cell therapy for metastatic brain cancers., Kaneko Y, Tajiri N, Staples M, Reyes S, Lozano D, Sanberg PR, Freeman TB, van Loveren H, Kim SU, Borlongan CV, Cell transplantation, 24, (4) 625 - 630,   2015年, 査読有り
  • Autologous stem cell transplant with gene therapy for Friedreich ataxia., Tajiri N, Staples M, Kaneko Y, Kim SU, Zesiewicz TA, Borlongan CV, Medical hypotheses, 83, (3) 296 - 298,   2014年09月, 査読有り
  • Stem cells and G-CSF for treating neuroinflammation in traumatic brain injury: aging as a comorbidity factor., Dela Peña I, Sanberg PR, Acosta S, Tajiri N, Lin SZ, Borlongan CV, Journal of neurosurgical sciences, 58, (3) 145 - 149,   2014年09月, 査読有り
  • Compromised blood-brain barrier competence in remote brain areas in ischemic stroke rats at the chronic stage., Garbuzova-Davis S, Haller E, Williams SN, Haim ED, Tajiri N, Hernandez-Ontiveros DG, Frisina-Deyo A, Boffeli SM, Sanberg PR, Borlongan CV, The Journal of comparative neurology, 522, (13) 3120 - 3137,   2014年09月, 査読有り
  • The role of DJ-1 in the oxidative stress cell death cascade after stroke., Pantcheva P, Elias M, Duncan K, Borlongan CV, Tajiri N, Kaneko Y, Neural regeneration research, 9, (15) 1430 - 1433,   2014年08月, 査読有り
  • Adult stem cell transplantation: is gender a factor in stemness?, Tajiri N, Duncan K, Borlongan MC, Pabon M, Acosta S, de la Pena I, Hernadez-Ontiveros D, Lozano D, Aguirre D, Reyes S, Sanberg PR, Eve DJ, Borlongan CV, Kaneko Y, International journal of molecular sciences, 15, (9) 15225 - 15243,   2014年08月, 査読有り
  • Oligodendrocytes engineered with migratory proteins as effective graft source for cell transplantation in multiple sclerosis., de la Pena I, Pabon M, Acosta S, Sanberg PR, Tajiri N, Kaneko Y, Borlongan CV, Cell medicine, 6, (3) 123 - 127,   2014年04月, 査読有り
  • ESTROGEN REPLACEMENT THERAPY FOR STROKE., Pabon M, Tamboli C, Tamboli S, Acosta S, De La Pena I, Sanberg PR, Tajiri N, Kaneko Y, Borlongan CV, Cell medicine, 6, (3) 111 - 122,   2014年04月, 査読有り
  • Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response., Tajiri N, Hernandez D, Acosta S, Shinozuka K, Ishikawa H, Ehrhart J, Diamandis T, Gonzales-Portillo C, Borlongan MC, Tan J, Kaneko Y, Borlongan CV, Brain research, 1559, 65 - 71,   2014年04月, 査読有り
  • Oxygen-glucose-deprived rat primary neural cells exhibit DJ-1 translocation into healthy mitochondria: a potent stroke therapeutic target., Kaneko Y, Tajiri N, Shojo H, Borlongan CV, CNS neuroscience & therapeutics, 20, (3) 275 - 281,   2014年03月, 査読有り
  • DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway., Kaneko Y, Shojo H, Burns J, Staples M, Tajiri N, Borlongan CV, Neurobiology of disease, 62, 56 - 61,   2014年02月, 査読有り
  • Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats., Tajiri N, Acosta SA, Shahaduzzaman M, Ishikawa H, Shinozuka K, Pabon M, Hernandez-Ontiveros D, Kim DW, Metcalf C, Staples M, Dailey T, Vasconcellos J, Franyuti G, Gould L, Patel N, Cooper D, Kaneko Y, Borlongan CV, Bickford PC, The Journal of neuroscience : the official journal of the Society for Neuroscience, 34, (1) 313 - 326,   2014年01月, 査読有り
  • Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke., Tajiri N, Acosta S, Portillo-Gonzales GS, Aguirre D, Reyes S, Lozano D, Pabon M, Dela Peña I, Ji X, Yasuhara T, Date I, Solomita MA, Antonucci I, Stuppia L, Kaneko Y, Borlongan CV, Frontiers in cellular neuroscience, 8,   2014年, 査読有り
  • Stem cell-paved biobridge facilitates neural repair in traumatic brain injury., Tajiri N, Duncan K, Antoine A, Pabon M, Acosta SA, de la Pena I, Hernadez-Ontiveros DG, Shinozuka K, Ishikawa H, Kaneko Y, Yankee E, McGrogan M, Case C, Borlongan CV, Frontiers in systems neuroscience, 8,   2014年, 査読有り
  • Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury., Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Sanberg PR, Sanchez-Ramos J, Song S, Kaneko Y, Borlongan CV, PloS one, 9, (3) ,   2014年, 査読有り
  • Behavioral and histopathological assessment of adult ischemic rat brains after intracerebral transplantation of NSI-566RSC cell lines., Tajiri N, Quach DM, Kaneko Y, Wu S, Lee D, Lam T, Hayama KL, Hazel TG, Johe K, Wu MC, Borlongan CV, PloS one, 9, (3) ,   2014年, 査読有り
  • An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside., Dailey T, Metcalf C, Mosley YI, Sullivan R, Shinozuka K, Tajiri N, Pabon M, Acosta S, Kaneko Y, van Loveren H, Borlongan CV, Journal of clinical medicine, 2, (4) 220 - 241,   2013年12月, 査読有り
  • Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy., Dailey T, Mosley Y, Pabon M, Acosta S, Tajiri N, van Loveren H, Kaneko Y, Borlongan CV, Neuroreport, 24, (18) 1067 - 1071,   2013年12月, 査読有り
  • Vasculogenesis in experimental stroke after human cerebral endothelial cell transplantation., Ishikawa H, Tajiri N, Shinozuka K, Vasconcellos J, Kaneko Y, Lee HJ, Mimura O, Dezawa M, Kim SU, Borlongan CV, Stroke, 44, (12) 3473 - 3481,   2013年12月, 査読有り
  • Regenerative medicine for epilepsy: from basic research to clinical application., Yasuhara T, Agari T, Kameda M, Kondo A, Kuramoto S, Jing M, Sasaki T, Toyoshima A, Sasada S, Sato K, Shinko A, Wakamori T, Okuma Y, Miyoshi Y, Tajiri N, Borlongan CV, Date I, International journal of molecular sciences, 14, (12) 23390 - 23401,   2013年11月, 査読有り
  • Vascular damage: a persisting pathology common to Alzheimer's disease and traumatic brain injury., Franzblau M, Gonzales-Portillo C, Gonzales-Portillo GS, Diamandis T, Borlongan MC, Tajiri N, Borlongan CV, Medical hypotheses, 81, (5) 842 - 845,   2013年11月, 査読有り
  • Ischemic stroke brain sends indirect cell death signals to the heart., Ishikawa H, Tajiri N, Vasconcellos J, Kaneko Y, Mimura O, Dezawa M, Borlongan CV, Stroke, 44, (11) 3175 - 3182,   2013年11月, 査読有り
  • Delta opioid receptor and its peptide: a receptor-ligand neuroprotection., Staples M, Acosta S, Tajiri N, Pabon M, Kaneko Y, Borlongan CV, International journal of molecular sciences, 14, (9) 17410 - 17419,   2013年08月, 査読有り
  • Human Umbilical Cord Blood for Transplantation Therapy in Myocardial Infarction., Acosta SA, Franzese N, Staples M, Weinbren NL, Babilonia M, Patel J, Merchant N, Simancas AJ, Slakter A, Caputo M, Patel M, Franyuti G, Franzblau MH, Suarez L, Gonzales-Portillo C, Diamandis T, Shinozuka K, Tajiri N, Sanberg PR, Kaneko Y, Miller LW, Borlongan CV, Journal of stem cell research & therapy, (Suppl 4) ,   2013年07月, 査読有り
  • Stem cell transplantation for neuroprotection in stroke., Shinozuka K, Dailey T, Tajiri N, Ishikawa H, Kaneko Y, Borlongan CV, Brain sciences, 3, (1) 239 - 261,   2013年07月, 査読有り
  • In vivo animal stroke models: a rationale for rodent and non-human primate models., Tajiri N, Dailey T, Metcalf C, Mosley YI, Lau T, Staples M, van Loveren H, Kim SU, Yamashima T, Yasuhara T, Date I, Kaneko Y, Borlongan CV, Translational stroke research, 4, (3) 308 - 321,   2013年06月, 査読有り
  • Stem Cells for Neurovascular Repair in Stroke., Shinozuka K, Dailey T, Tajiri N, Ishikawa H, Kim DW, Pabon M, Acosta S, Kaneko Y, Borlongan CV, Journal of stem cell research & therapy, 4, (4) ,   2013年05月, 査読有り
  • The battle of the sexes for stroke therapy: female- versus male-derived stem cells., Kaneko Y, Dailey T, Weinbren NL, Rizzi J, Tamboli C, Allickson JG, Kuzmin-Nichols N, Sanberg PR, Eve DJ, Tajiri N, Borlongan CV, CNS & neurological disorders drug targets, 12, (3) 405 - 412,   2013年05月, 査読有り
  • Stroke in the eye of the beholder., Ishikawa H, Caputo M, Franzese N, Weinbren NL, Slakter A, Patel M, Stahl CE, Jacotte MA, Acosta S, Franyuti G, Shinozuka K, Tajiri N, van Loveren H, Kaneko Y, Borlongan CV, Medical hypotheses, 80, (4) 411 - 415,   2013年04月, 査読有り
  • Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury., Acosta SA, Diamond DM, Wolfe S, Tajiri N, Shinozuka K, Ishikawa H, Hernandez DG, Sanberg PR, Kaneko Y, Borlongan CV, PloS one, 8, (12) ,   2013年, 査読有り
  • Traumatic brain injury precipitates cognitive impairment and extracellular Aβ aggregation in Alzheimer's disease transgenic mice., Tajiri N, Kellogg SL, Shimizu T, Arendash GW, Borlongan CV, PloS one, 8, (11) ,   2013年, 査読有り
  • Epidemiological survey-based formulae to approximate incidence and prevalence of neurological disorders in the United States: a meta-analysis., Borlongan CV, Burns J, Tajiri N, Stahl CE, Weinbren NL, Shojo H, Sanberg PR, Emerich DF, Kaneko Y, van Loveren HR, PloS one, 8, (10) ,   2013年, 査読有り
  • Stem cell-like dog placenta cells afford neuroprotection against ischemic stroke model via heat shock protein upregulation., Yu S, Tajiri N, Franzese N, Franzblau M, Bae E, Platt S, Kaneko Y, Borlongan CV, PloS one, 8, (9) ,   2013年, 査読有り
  • Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site., Tajiri N, Kaneko Y, Shinozuka K, Ishikawa H, Yankee E, McGrogan M, Case C, Borlongan CV, PloS one, 8, (9) ,   2013年, 査読有り
  • Regeneration of neuronal cells following cerebral injury., Dailey T, Tajiri N, Kaneko Y, Borlongan CV, Frontiers of neurology and neuroscience, 32, 54 - 61,   2013年, 査読有り
  • Blood-brain barrier alterations provide evidence of subacute diaschisis in an ischemic stroke rat model., Garbuzova-Davis S, Rodrigues MC, Hernandez-Ontiveros DG, Tajiri N, Frisina-Deyo A, Boffeli SM, Abraham JV, Pabon M, Wagner A, Ishikawa H, Shinozuka K, Haller E, Sanberg PR, Kaneko Y, Borlongan CV, PloS one, 8, (5) ,   2013年, 査読有り
  • Microglia activation as a biomarker for traumatic brain injury., Hernandez-Ontiveros DG, Tajiri N, Acosta S, Giunta B, Tan J, Borlongan CV, Frontiers in neurology, 4,   2013年, 査読有り
  • Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model., Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Grimmig B, Diamond DM, Sanberg PR, Bickford PC, Kaneko Y, Borlongan CV, PloS one, 8, (1) ,   2013年, 査読有り
  • Menstrual blood transplantation for ischemic stroke: Therapeutic mechanisms and practical issues., Rodrigues MC, Dmitriev D, Rodrigues A Jr, Glover LE, Sanberg PR, Allickson JG, Kuzmin-Nichols N, Tajiri N, Shinozuka K, Garbuzova-Davis S, Kaneko Y, Borlongan CV, Interventional medicine & applied science, 4, (2) 59 - 68,   2012年06月, 査読有り
  • A Step-up Approach for Cell Therapy in Stroke: Translational Hurdles of Bone Marrow-Derived Stem Cells., Glover LE, Tajiri N, Weinbren NL, Ishikawa H, Shinozuka K, Kaneko Y, Watterson DM, Borlongan CV, Translational stroke research, 3, (1) 90 - 98,   2012年03月, 査読有り
  • Nestin overexpression precedes caspase-3 upregulation in rats exposed to controlled cortical impact traumatic brain injury., Kaneko Y, Tajiri N, Yu S, Hayashi T, Stahl CE, Bae E, Mestre H, Franzese N, Rodrigues A Jr, Rodrigues MC, Ishikawa H, Shinozuka K, Hethorn W, Weinbren N, Glover LE, Tan J, Achyuta AH, van Loveren H, Sanberg PR, Shivsankar S, Borlongan CV, Cell medicine, 4, (2) 55 - 63,   2012年, 査読有り
  • Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro: role of the opioid system., Kaneko Y, Tajiri N, Su TP, Wang Y, Borlongan CV, PloS one, 7, (10) ,   2012年, 査読有り
  • Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats., Tajiri N, Acosta S, Glover LE, Bickford PC, Jacotte Simancas A, Yasuhara T, Date I, Solomita MA, Antonucci I, Stuppia L, Kaneko Y, Borlongan CV, PloS one, 7, (8) ,   2012年, 査読有り
  • Cell therapy for stroke: emphasis on optimizing safety and efficacy profile of endothelial progenitor cells., Kaneko Y, Tajiri N, Shinozuka K, Glover LE, Weinbren NL, Cortes L, Borlongan CV, Current pharmaceutical design, 18, (25) 3731 - 3734,   2012年, 査読有り
  • Cerebral aneurysm as an exacerbating factor in stroke pathology and a therapeutic target for neuroprotection., Tajiri N, Lau T, Glover LE, Shinozuka K, Kaneko Y, van Loveren H, Borlongan CV, Current pharmaceutical design, 18, (25) 3663 - 3669,   2012年, 査読有り
  • Electromagnetic treatment to old Alzheimer's mice reverses β-amyloid deposition, modifies cerebral blood flow, and provides selected cognitive benefit., Arendash GW, Mori T, Dorsey M, Gonzalez R, Tajiri N, Borlongan C, PloS one, 7, (4) ,   2012年, 査読有り
  • Immediate, but not delayed, microsurgical skull reconstruction exacerbates brain damage in experimental traumatic brain injury model., Glover LE, Tajiri N, Lau T, Kaneko Y, van Loveren H, Borlongan CV, PloS one, 7, (3) ,   2012年, 査読有り
  • The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders., Borlongan CV, Glover LE, Tajiri N, Kaneko Y, Freeman TB, Progress in neurobiology, 95, (2) 213 - 228,   2011年10月, 査読有り
  • GDNF-pretreatment enhances the survival of neural stem cells following transplantation in a rat model of Parkinson's disease., Wang F, Kameda M, Yasuhara T, Tajiri N, Kikuchi Y, Liang HB, Tayra JT, Shinko A, Wakamori T, Agari T, Date I, Neuroscience research, 71, (1) 92 - 98,   2011年09月, 査読有り
  • Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion., Kikuchi Y, Yasuhara T, Agari T, Kondo A, Kuramoto S, Kameda M, Kadota T, Baba T, Tajiri N, Wang F, Tayra JT, Liang H, Miyoshi Y, Borlongan CV, Date I, Journal of cellular physiology, 226, (5) 1390 - 1398,   2011年05月, 査読有り
  • Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection., Kaneko Y, Hayashi T, Yu S, Tajiri N, Bae EC, Solomita MA, Chheda SH, Weinbren NL, Parolini O, Borlongan CV, Journal of pineal research, 50, (3) 272 - 280,   2011年04月, 査読有り
  • Toward personalized cell therapies: autologous menstrual blood cells for stroke., Rodrigues MC, Glover LE, Weinbren N, Rizzi JA, Ishikawa H, Shinozuka K, Tajiri N, Kaneko Y, Sanberg PR, Allickson JG, Kuzmin-Nichols N, Garbuzova-Davis S, Voltarelli JC, Cruz E, Borlongan CV, Journal of biomedicine & biotechnology, 2011,   2011年, 査読有り
  • Striatal stimulation nurtures endogenous neurogenesis and angiogenesis in chronic-phase ischemic stroke rats., Morimoto T, Yasuhara T, Kameda M, Baba T, Kuramoto S, Kondo A, Takahashi K, Tajiri N, Wang F, Meng J, Ji YW, Kadota T, Maruo T, Kinugasa K, Miyoshi Y, Shingo T, Borlongan CV, Date I, Cell transplantation, 20, (7) 1049 - 1064,   2011年, 査読有り
  • Amniotic fluid as a rich source of mesenchymal stromal cells for transplantation therapy., Antonucci I, Stuppia L, Kaneko Y, Yu S, Tajiri N, Bae EC, Chheda SH, Weinbren NL, Borlongan CV, Cell transplantation, 20, (6) 789 - 795,   2011年, 査読有り
  • Intravenous infusion of GDNF gene-modified human umbilical cord blood CD34+ cells protects against cerebral ischemic injury in spontaneously hypertensive rats., Ou Y, Yu S, Kaneko Y, Tajiri N, Bae EC, Chheda SH, Stahl CE, Yang T, Fang L, Hu K, Borlongan CV, Yu G, Brain research, 1366, 217 - 225,   2010年12月, 査読有り
  • Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse., Masuda T, Maki M, Hara K, Yasuhara T, Matsukawa N, Yu S, Bae EC, Tajiri N, Chheda SH, Solomita MA, Weinbren N, Kaneko Y, Kirov SA, Hess DC, Hida H, Borlongan CV, Brain research, 1355, 228 - 239,   2010年10月, 査読有り
  • Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation., Bachstetter AD, Jernberg J, Schlunk A, Vila JL, Hudson C, Cole MJ, Shytle RD, Tan J, Sanberg PR, Sanberg CD, Borlongan C, Kaneko Y, Tajiri N, Gemma C, Bickford PC, PloS one, 5, (5) ,   2010年05月, 査読有り
  • Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1alpha., Wang F, Yasuhara T, Shingo T, Kameda M, Tajiri N, Yuan WJ, Kondo A, Kadota T, Baba T, Tayra JT, Kikuchi Y, Miyoshi Y, Date I, BMC neuroscience, 11,   2010年04月, 査読有り
  • Exercise exerts neuroprotective effects on Parkinson's disease model of rats., Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, Wang F, Baba T, Tayra JT, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I, Brain research, 1310, 200 - 207,   2010年01月, 査読有り
  • Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/Akt signaling pathway., Baba T, Kameda M, Yasuhara T, Morimoto T, Kondo A, Shingo T, Tajiri N, Wang F, Miyoshi Y, Borlongan CV, Matsumae M, Date I, Stroke, 40, (11) e598 - 605,   2009年11月, 査読有り
  • The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting., Jing M, Shingo T, Yasuhara T, Kondo A, Morimoto T, Wang F, Baba T, Yuan WJ, Tajiri N, Uozumi T, Murakami M, Tanabe M, Miyoshi Y, Zhao S, Date I, Brain research, 1295, 203 - 217,   2009年10月, 査読有り
  • Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson's disease model of rats with enhanced neurogenesis., Kadota T, Shingo T, Yasuhara T, Tajiri N, Kondo A, Morimoto T, Yuan WJ, Wang F, Baba T, Tokunaga K, Miyoshi Y, Date I, Brain research, 1254, 120 - 127,   2009年02月, 査読有り
  • Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons., Yuan WJ, Yasuhara T, Shingo T, Muraoka K, Agari T, Kameda M, Uozumi T, Tajiri N, Morimoto T, Jing M, Baba T, Wang F, Leung H, Matsui T, Miyoshi Y, Date I, BMC neuroscience, 9,   2008年08月, 査読有り

書籍等出版物

  • Stem cell therapy for ischemic stroke, Nguyen HV, Tajiri N, Borlongan CV, 共著, Non-Neuronal Mechanisms of Brain Damage & Repair After Stroke -‘Translational Stroke Research', Springer,   2016年, ISBN:978-3-319-32337-4
  • Wharton’s jelly stem cells, Bastawrous M, Pabon MM, Acosta SA, Dela Peña IC, Hernandez-Ontiveros DG, Staples M, Shinozuka K, Pantcheva P, Tajiri N, Kaneko Y, Borlongan CV, 共著, Fetal Stem Cells in Regenerative Medicine -‘Stem Cell Biology & Regenerative Medicine', Springer,   2016年, ISBN:978-1-4939-3483-6
  • Characterization of the phenotypic features, immuno-modulatory properties and therapeutic potentials of Wharton’s jelly-derived mesenchymal stromal cells, Dela Peña IC, Bastawrous M, Lozano D, Aguirre D, Hernandez-Ontiveros DG, Acosta SA, Pabon MM, Tajiri N, Kaneko Y, Borlongan CV, 共著, Cellular Therapy for Stroke & CNS Injuries -‘Translational Stroke Research', Springer,   2015年, ISBN:978-3-319-11481-1
  • Stem cells for neurovascular repair in CNS trauma, Pabon MM, Dailey T, Tajiri N, Shinozuka K, Ishikawa H, Acosta SA, Kaneko Y, Borlongan CV, 共著, Vascular Mechanisms in CNS Trauma -‘Translational Stroke Research', Springer,   2014年, ISBN:978-1-4614-8689-3
  • Melatonin: Therapeutic value and neuroprotection in stroke, Franzblau M, Franzese N, Gonzales-Portillo GS, Gonzales-Portillo C, Staples M, Borlongan MC, Tajiri N, Kaneko Y, Borlongan CV, 共著, Melatonin: Therapeutic Value & Neuroprotection, CRC Press,   2014年, ISBN:9781482220094
  • Stem cell therapies in neurology, Tajiri N, Staples M, Acosta SA, Pabon MM, Dailey T, Kaneko Y, Borlongan CV, 共著, Adult Stem Cell Therapies: Alternatives to Plasticity -'Stem Cell Biology & Regenerative Medicine', Springer,   2014年, ISBN:978-1-4939-1001-4
  • Different sources of stem cells for transplantation therapy in stroke, Dailey T, Eve DJ, Tajiri N, Lau T, Mosley YI, van Loveren H, Sanberg PR, Kaneko Y, Borlongan CV, 共著, Cell-Based Therapies in Stroke, Springer,   2013年, ISBN:978-3-7091-1175-8
  • Amnion-derived cells for stroke restorative therapy, Tajiri N, Glover LE, Borlongan CV, 共著, Perinatal Stem Cells -‘2nd Edition’, Wiley-Blackwell,   2013年, ISBN:978-1-118-49794-4
  • Regeneration of neuronal cells following cerebral injury, Dailey T, Tajiri N, Kaneko Y, Borlongan CV, 共著, Clinical Recovery from CNS Damage -'Frontiers of Neurology & Neuroscience', Karger,   2013年, ISBN:978-3-318-02309-1
  • Cell proliferation in the brains of adult rats exposed to traumatic brain injury, Acosta SA, Tajiri N, Bickford PC, Borlongan CV, 共著, Neurostereology: Unbiased Stereology of Neural Systems -‘1st Edition’, Wiley-Blackwell,   2013年, ISBN:978-1-118-44418-4

講演・口頭発表等

  • 基礎研究から臨床応用へ向けて~脳疾患に対するリハビリテーションの展望~, 田尻 直輝, 第94回 日本生理学会大会,   2017年03月30日, 招待あり
  • Combination treatment of moderate hypothermia and mesenchymal stem cell amplifies neuroprotection in, 田尻 直輝, 第7回日本ニューロリハビリテーョン学会学術集会,   2016年05月21日
  • DJ-1 deletion impedes bone marrow stem cell capacity and worsens stroke outcomes, 田尻 直輝, 26th Annual USF Health Research Day 2016,   2016年02月19日
  • The preclinical basis of neurosurgical stem cell and rehabilitation combination therapies for neurological diseases via DJ-1, 田尻 直輝, The 1st Regenerative Rehabilitation Seminar,   2015年08月01日, 招待あり
  • Kainic acid-induced golgi complex fragmentation/dispersal shifts the proteolysis of reelin in primary rat neuronal cells: An in vitro model of early stage epilepsy, 田尻 直輝, The 38th Annual Meeting of the Japan Neuroscience Society,   2015年07月28日
  • Kainic acid-induced golgi complex fragmentation/dispersal shifts the proteolysis of reelin in primary rat neuronal cells: An in vitro model of early stage epilepsy, 田尻 直輝, 22nd Annual American Society for Neural Therapy and Repair Conference,   2015年04月30日
  • KPT-350, a Selective Inhibitor of Nuclear Export (SINE) compound, improves behavioral and histological parameters in a rat model of traumatic brain injury, 田尻 直輝, 12th Annual North American Brain Injury Society (NABIS) Conference on Brain Injury 2015,   2015年04月29日, 招待あり
  • Kainic acid-induced golgi complex fragmentation/dispersal shifts the proteolysis of reelin in primary rat neuronal cells: An in vitro model of early stage epilepsy, 田尻 直輝, 25th Annual USF Health Research Day 2015,   2015年02月20日
  • Preclinical basis for combination therapy of hyperbaric oxygen therapy and rehabilitation therapy in traumatic brain injury, 田尻 直輝, Joining Forces to Restore Lives: Nursing Research, Education and Practice in Veterans Health,   2014年11月17日
  • Traumatic Brain Injury: A Review of Current Basic Science Research, 田尻 直輝, Neuro Trauma Update,   2014年10月23日, 招待あり
  • A nuclear attack: Sequestration of traumatic brain injury-induced cell death at the nuclear level via selective inhibitors of nuclear export (SINE), 田尻 直輝, 21st Annual American Society for Neural Therapy and Repair Conference,   2014年04月24日
  • Hyperbaric oxygen treatment and exercise therapy attenuate behavioral and histological deficits in adult rats exposed to experimental traumatic brain injury, 田尻 直輝, The 3rd Annual Symposium on Regenerative Rehabilitation,   2014年04月11日

競争的資金

  • 頭部外傷うつ病モデルラットに対する細胞移植と運動刺激の併用療法の検討, 文部科学省, 科学研究費助成事業(科学研究費補助金)基盤研究(C),   2018年 - 2020年, 田尻 直輝
  • Stem cell-paved biobridges in TBI with AD-like pathology, USF Health Byrd Alzheimer’s Institute, Byrd Institute Small Grants Program,   2014年07月 - 2016年06月, 田尻 直輝
  • 頭部外傷における神経新生とうつ症状との関連性: 細胞移植とリハビリの併用療法の検討, 文部科学省, 私立大学等研究設備整備費等補助金(私立大学等研究設備等整備費),   2016年, 田尻 直輝
  • MicroRNA, RT-PCR and immunocytochemical profiling of human temporal lobe epilepsy brain reveals an upregulation of miR-34b/c and a downregulation of miR-592 in the hippocampus and amygdala compared to the neocortex, University of South Florida, USF Postdoctoral Scholar Research Grant Award 2012-2013,   2012年12月, 田尻 直輝
  • パーキンソン病関与タンパク質DJ-1の神経保護作用機序及びサイクロスポリンが有する神経保護作用の分子メカニズムについて, 独立行政法人日本学術振興会学術助成金, 若手研究者インターナショナル・トレーニング・プログラム,   2010年03月 - 2011年02月, 田尻 直輝

教育活動情報

担当経験のある科目

  • 実験手法概論, 名古屋市立大学大学院
  • 生理学・実習(生理系コース), 名古屋市立大学
  • 心理学研究指導(通信制), 吉備国際大学大学院
  • 心理学研究指導, 吉備国際大学大学院
  • 高次脳機能研究(通信制), 吉備国際大学大学院
  • 高次脳機能研究, 吉備国際大学大学院
  • 特別研究Ⅳ, 吉備国際大学大学院
  • 特別研究Ⅲ, 吉備国際大学大学院
  • 特別研究Ⅱ, 吉備国際大学大学院
  • 特別研究Ⅰ, 吉備国際大学大学院
  • 高次脳機能特論, 吉備国際大学大学院
  • 研究方法論, 南フロリダ大学
  • 神経、筋疾患に対する理学療法学及び実習, 南フロリダ大学
  • 基礎運動学、評価学実習、人体解剖学及び実習, 南フロリダ大学
  • 解剖生理学 国家試験対策, 順正高等看護福祉専門学校
  • 解剖生理学Ⅴ(運動器・脳神経・感覚器系), 順正高等看護福祉専門学校
  • 解剖生理学Ⅲ(呼吸器・内分泌系), 順正高等看護福祉専門学校
  • 解剖生理学Ⅰ(総論), 順正高等看護福祉専門学校
  • 吉備国際大から世界へ, 吉備国際大学
  • 社会の中の心理学, 吉備国際大学
  • キャリア開発Ⅲ, 吉備国際大学
  • キャリア開発Ⅰ, 吉備国際大学
  • 臨床の倫理, 吉備国際大学
  • 臨床神経学, 吉備国際大学
  • 神経診断学, 吉備国際大学
  • 神経解剖学, 吉備国際大学
  • 解剖学, 吉備国際大学
  • 運動学, 朝日医療技術専門学校
  • 機能評価学・実習, 朝日医療技術専門学校


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